<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2565-005X</journal-id>
<journal-title><![CDATA[Gaceta mexicana de oncología]]></journal-title>
<abbrev-journal-title><![CDATA[Gac. mex. oncol.]]></abbrev-journal-title>
<issn>2565-005X</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Mexicana de Oncología A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2565-005X2022000500016</article-id>
<article-id pub-id-type="doi">10.24875/j.gamo.22000125</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Clinical spectrum of a syndromic diagnosis: Lethal midline granuloma]]></article-title>
<article-title xml:lang="es"><![CDATA[Espectro clínico de un diagnóstico sindrómico: granuloma letal de línea media]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martínez-Rodríguez]]></surname>
<given-names><![CDATA[Juliana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mora]]></surname>
<given-names><![CDATA[Mayra A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Buitrago-Toro]]></surname>
<given-names><![CDATA[Kenny]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A4 "/>
<xref ref-type="aff" rid="Af5"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Jiménez-Salazar]]></surname>
<given-names><![CDATA[Silvana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Leiva]]></surname>
<given-names><![CDATA[Lina Ma.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cárdenas-Losada]]></surname>
<given-names><![CDATA[Luis F.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A6"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Universitario Hernando Moncaleano Perdomo Emergency Department ]]></institution>
<addr-line><![CDATA[Neiva ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Surcolombiana School of Health ]]></institution>
<addr-line><![CDATA[Neiva ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Surcolombiana Research Group MI Dneuropsy ]]></institution>
<addr-line><![CDATA[Neiva ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad Surcolombiana Internal Medicine Department ]]></institution>
<addr-line><![CDATA[Neiva ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Universidad Pontificia Bolivariana Infectious Diseases Department ]]></institution>
<addr-line><![CDATA[Medellín ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af6">
<institution><![CDATA[,Hospital Universitario Hernando Moncaleano Perdomo Hemato-Oncology Service ]]></institution>
<addr-line><![CDATA[Neiva ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2022</year>
</pub-date>
<volume>21</volume>
<fpage>16</fpage>
<lpage>20</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2565-005X2022000500016&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2565-005X2022000500016&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2565-005X2022000500016&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract A 73-year-old man presented to the emergency department for 2 months of erythema, warmth, and blushing on the tip of the nose, with progression to ulcerative and granulomatous tissue and posterior necrotizing compromise of the nasal septum, despite antibiotic schemes. A diagnosis of lethal midline granuloma was made, a disease with a wide spectrum of etiological diagnostic possibilities and usually a poor prognosis. A biopsy sample confirms a NK/T-cell lymphoma. The patient did not accept the proposed chemotherapeutic treatment. He requested voluntary discharge and later died.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen Un hombre de 73 años ingresó al servicio de urgencias por dos meses de eritema, calor y enrojecimiento de la punta nasal, con posterior progresión y compromiso granulomatoso y necrotizante del tabique nasal. Se realizó diagnóstico de granuloma letal de la línea media, un síndrome clínico con un amplio abanico de opciones diagnósticas y generalmente un pobre pronóstico. La biosia confirmó un linfoma de células T natural killer (NK-T). El paciente no acepta tratamiento quimioterápico y posteriormente fallece.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Extranodal NK-T-cell lymphoma]]></kwd>
<kwd lng="en"><![CDATA[Lethal midline granuloma]]></kwd>
<kwd lng="en"><![CDATA[Colombia]]></kwd>
<kwd lng="es"><![CDATA[Linfoma extranodal de célula NK-T]]></kwd>
<kwd lng="es"><![CDATA[Granuloma letal de línea media]]></kwd>
<kwd lng="es"><![CDATA[Colombia]]></kwd>
</kwd-group>
</article-meta>
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