<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2565-005X</journal-id>
<journal-title><![CDATA[Gaceta mexicana de oncología]]></journal-title>
<abbrev-journal-title><![CDATA[Gac. mex. oncol.]]></abbrev-journal-title>
<issn>2565-005X</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Mexicana de Oncología A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2565-005X2022000400135</article-id>
<article-id pub-id-type="doi">10.24875/j.gamo.22000110</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[New insights about organoids as model of study for breast cancer research]]></article-title>
<article-title xml:lang="es"><![CDATA[Nuevas perspectivas sobre organoides como modelo de estudio para investigación en cáncer de mama]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Macías-Paz]]></surname>
<given-names><![CDATA[Ignacio U.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rivera-Arenas]]></surname>
<given-names><![CDATA[Alejandro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Reyna-Beltrán]]></surname>
<given-names><![CDATA[Elizabeth]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Tavera-Tapia]]></surname>
<given-names><![CDATA[Alejandra]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Autónoma de Tamaulipas  Dr. Alberto Romo Caballero´s School of Medicine]]></institution>
<addr-line><![CDATA[Tampico ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2022</year>
</pub-date>
<volume>21</volume>
<numero>4</numero>
<fpage>135</fpage>
<lpage>142</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2565-005X2022000400135&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2565-005X2022000400135&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2565-005X2022000400135&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Although the current advances in breast cancer (BC) research, it is still one of the leading causes of death from neoplastic diseases in women and causes millions of new cases worldwide. It has become evident that traditional methods used for BC research have serious limitations. We have reviewed the most recent findings in the application of Breast Cancer Organoids (BCOs) to explore extremely rare BC forms, BC hallmarks, biobanks, and interaction with the microenvironment. Moreover, we explored the importance of its applicability in clinical trials, drug screening, and personalized medicine.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen A pesar de los avances actuales en la investigación del cáncer de mama (CM), sigue siendo una de las principales causas de muerte por enfermedades neoplásicas en mujeres y provoca millones de casos nuevos en todo el mundo. Se ha hecho evidente que los métodos tradicionales utilizados para la investigación en CM tienen serias limitaciones. Hemos revisado los hallazgos más recientes en la aplicación de organoides de cáncer de mama (OCM) para explorar formas extremadamente raras de CM, características distintivas de CM, biobancos e interacción con el microambiente. Además, exploramos la importancia de su aplicabilidad en ensayos clínicos, cribado de fármacos y medicina personalizada.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Organoids]]></kwd>
<kwd lng="en"><![CDATA[Breast cancer]]></kwd>
<kwd lng="en"><![CDATA[Clinical trials]]></kwd>
<kwd lng="en"><![CDATA[Personalized medicine]]></kwd>
<kwd lng="es"><![CDATA[Organoides]]></kwd>
<kwd lng="es"><![CDATA[Cáncer de mama]]></kwd>
<kwd lng="es"><![CDATA[Ensayos clínicos]]></kwd>
<kwd lng="es"><![CDATA[Medicina personalizada]]></kwd>
</kwd-group>
</article-meta>
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