<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2565-005X</journal-id>
<journal-title><![CDATA[Gaceta mexicana de oncología]]></journal-title>
<abbrev-journal-title><![CDATA[Gac. mex. oncol.]]></abbrev-journal-title>
<issn>2565-005X</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Mexicana de Oncología A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2565-005X2019000500006</article-id>
<article-id pub-id-type="doi">10.24875/j.gamo.19000261</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Recién nacido con hemangioendotelioma maligno en órbita: informe de caso]]></article-title>
<article-title xml:lang="en"><![CDATA[A newborn with orbit hemangioendothelioma: case report]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Liquidano-Pérez]]></surname>
<given-names><![CDATA[Eduardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Xiqui-Jardines]]></surname>
<given-names><![CDATA[Laura Alejandra]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Borbolla-Pertierra]]></surname>
<given-names><![CDATA[Ana María]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Aguilar Ortiz]]></surname>
<given-names><![CDATA[Marco Rodrigo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Secretaría de Salud Instituto Nacional de Pediatría ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Secretaría de Salud Instituto Nacional de Pediatría ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Secretaría de Salud Instituto Nacional de Pediatría ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Secretaría de Salud Instituto Nacional de Pediatría ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2019</year>
</pub-date>
<volume>18</volume>
<fpage>31</fpage>
<lpage>34</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2565-005X2019000500006&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2565-005X2019000500006&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2565-005X2019000500006&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La proptosis rápidamente progresiva en neonatos es infrecuente y puede resultar en detrimento de la función ocular e incluso poner en peligro la vida. Se presenta el caso de un varón de 12 días de vida con proptosis desplazada a temporal superior, edema bipalpebral y quemosis en ojo derecho. Se realizó tomografia computarizada evidenciando lesión intraorbitaria que refuerza con el contraste. Se toma biopsia por aspiración con aguja fina encontrando células neoplásicas. Se procedió a la resección tumoral y estudio histopatológico con diagnóstico definitivo de hemangioendotelioma epitelioide maligno (HEM). Recibió 6 cursos de quimioterapia: vincristina, actinomicina y cisplatino; en la reevaluación se encontró tumor residual, decidiéndose la enucleación del ojo derecho. Actualmente el paciente se encuentra en vigilancia. El HEM es una neoplasia vascular de comportamiento controvertido, desde indolente hasta progresión y metástasis. El tratamiento definitivo es la resección completa del tumor; la radioterapia o quimioterapia aisladas no son opciones curativas. Los tumores malignos orbitarios en el niño pueden tratarse eficientemente con un diagnóstico temprano. El papel del pediatra en estos casos debe ser un diagnóstico temprano y una referencia oportuna.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Background: The rapidly progressive proptosis in neonates is not frequent, it comprises a broad spectrum of pathologies that might endanger life and ocular function.  Case description: A 12-day male began with right rapidly progressive proptosis and palpebral edema. On examination, displaced proptosis was observed towards the superior temporal region, edema of both eyelids and chemosis in the right eye. A CT was performed evidencing a neoproliferative intraorbital lesion that reinforces with contrast. A BAAF was taken, evidencing neoplastic cells. The tumor was resected and histopathological study identified vascular neoplasia with a definitive diagnosis of epithelioid hemangioendothelioma. He received treatment with 6 courses of vincristine, actinomycin and cisplatin; in the re-evaluation, a residual tumor was found, therefore enucleation of the right eye was performed due to failure in the response to treatment. Currently, the patient is under surveillance.  Discussion: The causes of ocular proptosis in the neonate are similar to those of other ages. Orbit primary tumors represent a large percentage of malignant causes. The epithelioid hemangioendothelioma is a vascular neoplasm which behavior is controversial, some cases are indolent and others present progression and metastasis. The treatment is the complete resection of the tumor; neither radiation therapy nor chemotherapy alone are curative options. Orbital malignancies in the child can be treated effectively with a timely diagnosis. The pediatrician in these cases should have an adequate suspicion and opportune referral.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Neoplasia vascular]]></kwd>
<kwd lng="es"><![CDATA[Proptosis]]></kwd>
<kwd lng="es"><![CDATA[Hemangioendotelioma epitelioide]]></kwd>
<kwd lng="en"><![CDATA[Vascular neoplasm]]></kwd>
<kwd lng="en"><![CDATA[Proptosis]]></kwd>
<kwd lng="en"><![CDATA[Epithelioid hemangioendothelioma]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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