<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2524-177X</journal-id>
<journal-title><![CDATA[Revista médica del Hospital General de México]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. med. Hosp. Gen. Méx.]]></abbrev-journal-title>
<issn>2524-177X</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Médica del Hospital General de México A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2524-177X2025000400223</article-id>
<article-id pub-id-type="doi">10.24875/hgmx.24000055</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Fungal multivalvular endocarditis: literature review and case report]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Herrera-Salgado]]></surname>
<given-names><![CDATA[Jesser M.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Berrios-Muñiz]]></surname>
<given-names><![CDATA[Edgar O.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Altamirano-Ramírez]]></surname>
<given-names><![CDATA[Yader E.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gutiérrez-Casco]]></surname>
<given-names><![CDATA[Vilma E.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Briones-Garduño]]></surname>
<given-names><![CDATA[Jesús C.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gutiérrez-Chavarría]]></surname>
<given-names><![CDATA[Sindy A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto de Seguridad y Servicios Sociales para los Trabajadores del Estado Medical Education and Research Coordination ]]></institution>
<addr-line><![CDATA[Mexico City ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Militar de Especialidades de la Mujer y Neonatología Obstetric Intensive Care Unit ]]></institution>
<addr-line><![CDATA[Mexico City ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital Militar Alejandro Dávila Bolaños Critical Care Division ]]></institution>
<addr-line><![CDATA[Managua ]]></addr-line>
<country>Nicaragua</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Hospital General de México Dr. Eduardo Liceaga, Secretaría de Salud Education and Research Coordination ]]></institution>
<addr-line><![CDATA[Mexico City ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Instituto de Seguridad y Servicios Sociales para los Trabajadores del Estado Bone Marrow Transplant Unit ]]></institution>
<addr-line><![CDATA[Mexico City ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2025</year>
</pub-date>
<volume>88</volume>
<numero>4</numero>
<fpage>223</fpage>
<lpage>229</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2524-177X2025000400223&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2524-177X2025000400223&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2524-177X2025000400223&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract The incidence of fungal endocarditis (FEs) has decreased in most developed countries with access to harm-reduction policies and with improved infection control procedures during cardiac surgery. Use of specific blood culture bottles for diagnosis of FEs has decreased due to the optimization of media and automated culture systems. New antifungal agents available since the early 2000s may represent a dramatic improvement for FEs. The optimum antifungal therapy still remains debatable. Treating Candida endocarditis can be difficult because the Candida species can form biofilms on native and prosthetic heart valves. Combined treatment appears superior to monotherapy. Combination of antifungal therapy and surgical debridement might bring about better prognosis. In this clinical case report, we aim to make a literature review and present a challenging and rare clinical case.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Endocarditis]]></kwd>
<kwd lng="en"><![CDATA[Multivalvular endocarditis]]></kwd>
<kwd lng="en"><![CDATA[Fungal cardiac infections]]></kwd>
</kwd-group>
</article-meta>
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