<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2524-177X</journal-id>
<journal-title><![CDATA[Revista médica del Hospital General de México]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. med. Hosp. Gen. Méx.]]></abbrev-journal-title>
<issn>2524-177X</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Médica del Hospital General de México A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2524-177X2025000400209</article-id>
<article-id pub-id-type="doi">10.24875/hgmx.24000071</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Efficacy of glucocorticoids versus placebo on mortality in patients with community-acquired pneumonia: systematic review]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hernández-Montes]]></surname>
<given-names><![CDATA[Paul E.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Montes-Sevilla]]></surname>
<given-names><![CDATA[Lenyn D.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto de Seguridad y Servicios Sociales para los Trabajadores del Estado Hospital General Dr. Aquiles Calles Ramírez Department of General Medicine]]></institution>
<addr-line><![CDATA[Tepic Nayarit]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Departament of Surgery ]]></institution>
<addr-line><![CDATA[Mexico City ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2025</year>
</pub-date>
<volume>88</volume>
<numero>4</numero>
<fpage>209</fpage>
<lpage>216</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2524-177X2025000400209&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2524-177X2025000400209&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2524-177X2025000400209&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract The use of glucocorticoids (GCS) in acute respiratory distress syndrome is well documented; however, their use in community-acquired pneumonia (CAP) is controversial, and their impact on mortality is not well defined. The objective is evaluating the efficacy of GCS use compared to placebo in patients with CAP through a systematic review. A systematic review of the literature was conducted in databases such as PubMed, Scopus, and Web of Science for randomized clinical trials published between 2019 and 2024. Articles were classified according to the level of evidence by the Oxford Center for Evidence-Based Medicine. In the results, seven original articles were included, all of which were randomized clinical trials. The studies included a total of 2847 participants, evaluating outcomes such as mortality, days of mechanical ventilation use, length of hospital stay, need for vasopressor use, development of shock, and ARDS. The use of hydrocortisone showed a significant benefit in reducing mortality at 28 days and the need for mechanical ventilation and vasopressors. In contrast, the use of dexamethasone and methylprednisolone did not show significant differences compared to placebo.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Corticosteroids]]></kwd>
<kwd lng="en"><![CDATA[Pneumonia]]></kwd>
<kwd lng="en"><![CDATA[Mortality]]></kwd>
<kwd lng="en"><![CDATA[Placebo]]></kwd>
<kwd lng="en"><![CDATA[Systematic review]]></kwd>
</kwd-group>
</article-meta>
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<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Rodondi]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Blum]]></surname>
<given-names><![CDATA[MR]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Adjunct prednisone in community-acquired pneumonia:180-day outcome of a multicenter, double-blind, randomized, placebo-controlled trial]]></article-title>
<source><![CDATA[BMC Pulm Med]]></source>
<year>2023</year>
<volume>23</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>500</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
