<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2448-9190</journal-id>
<journal-title><![CDATA[Revista alergia México]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. alerg. Méx.]]></abbrev-journal-title>
<issn>2448-9190</issn>
<publisher>
<publisher-name><![CDATA[Colegio Mexicano de Inmunología Clínica y Alergia A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2448-91902025000300006</article-id>
<article-id pub-id-type="doi">10.29262/ram.v72i3.1502</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Síndrome de DRESS inducido por diosmina-hesperidina: reactivación inmunológica por herpes virus]]></article-title>
<article-title xml:lang="en"><![CDATA[Diosmin-hesperidin-induced DRESS syndrome: immune reactivation by herpesvirus]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Flores-García]]></surname>
<given-names><![CDATA[Nataly]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Correa-Serrano]]></surname>
<given-names><![CDATA[Carlos]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cardenas-Favela]]></surname>
<given-names><![CDATA[Juan Carlos]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cadenas-García]]></surname>
<given-names><![CDATA[Diana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Villarreal-González]]></surname>
<given-names><![CDATA[Rosalaura]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado Hospital Regional Dr. Valentín Gómez Farías ]]></institution>
<addr-line><![CDATA[Zapopan Jalisco]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Autónoma de Nuevo León Centro Universitario Contra el Cáncer Hospital Universitario &#8220;Dr. José Eleuterio González&#8221;]]></institution>
<addr-line><![CDATA[Monterrey Nuevo León]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2025</year>
</pub-date>
<volume>72</volume>
<numero>3</numero>
<fpage>57</fpage>
<lpage>60</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2448-91902025000300006&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2448-91902025000300006&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2448-91902025000300006&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Antecedentes: La reacción medicamentosa con eosinofilia y síntomas sistémicos (DRESS) es una reacción adversa cutánea grave. La incidencia es de 1&#8211;1,000,000 con mortalidad de 3.8-10%, y es una enfermedad relacionada con reactivación por virus del herpes simple.  Reporte de caso: Mujer de 34 años con atopia e insuficiencia venosa. Manifestó habones pruriginosos en el rostro y los brazos, que evolucionó a exantema morbiliforme, edema facial, fiebre, linfadenopatía y descamación. La biometría hemática no mostró alteraciones; AST:837U/L, ALT:11352U/L. debido a la sospecha de síndrome de DRESS se inició el tratamiento con corticosteroides y obtención de una biopsia. Al interrogatorio, la paciente refirió haber consumido diosmina-hesperidina y sometido a fotoprotección sistémica (Heliocare360°®) 21 días previos a la dermatosis. El examen histopatológico reportó epidermis atrófica, degeneración vacuolar e infiltrado inflamatorio. Se administraron corticosteroides sistémicos durante tres semanas, con reacción satisfactoria. Dos meses posteriores tuvo reactivación de la dermatosis e hipertransaminasemia; el panel de autoanticuerpos y la serología fue positiva a IgM para virus del herpes simple.  Conclusión: Este caso subraya la necesidad de considerar reacciones de hipersensibilidad graves, incluso con fármacos de uso común y aparente bajo riesgo. Se enfatiza la importancia de un abordaje integral, que incluya la identificación del medicamento sospechoso, exclusión de diagnósticos diferenciales, seguimiento clínico prolongado y vigilancia por posible reactivación viral.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Background: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe cutaneous adverse reaction. The incidence is 1-1,000,000 with a mortality rate of 3.8-10%, and it is a disease associated with reactivation of the herpes simplex virus.  Case report: A 34-year-old woman with atopy and venous insufficiency presented with pruritic hives on her face and arms, which progressed to a morbilliform rash, facial edema, fever, lymphadenopathy, and scaling. A complete blood count showed no abnormalities: AST: 837 U/L, ALT: 11352 U/L. Due to the suspicion of DRESS syndrome, treatment with corticosteroids was initiated and a biopsy was obtained. Upon questioning, the patient reported having taken diosmin-hesperidin and undergone systemic sunscreen (Heliocare360°®) 21 days prior to the onset of the rash. Histopathological examination revealed atrophic epidermis, vacuolar degeneration, and inflammatory infiltrate. Systemic corticosteroids were administered for three weeks, with a satisfactory response. Two months later, the patient experienced reactivation of the dermatosis and hypertransaminasemia; the autoantibody panel and serology were positive for IgM for herpes simplex virus.  Conclusion: This case underscores the need to consider severe hypersensitivity reactions, even with commonly used and apparently low-risk drugs. The importance of a comprehensive approach, including identification of the suspected medication, exclusion of differential diagnoses, prolonged clinical follow-up, and surveillance for possible viral reactivation, is emphasized.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Síndrome de DRESS]]></kwd>
<kwd lng="es"><![CDATA[Incidencia]]></kwd>
<kwd lng="es"><![CDATA[Virus del herpes simple]]></kwd>
<kwd lng="es"><![CDATA[Linfadenopatía]]></kwd>
<kwd lng="es"><![CDATA[Diosmina-herperidina]]></kwd>
<kwd lng="es"><![CDATA[Exantema]]></kwd>
<kwd lng="es"><![CDATA[Corticosteroides]]></kwd>
<kwd lng="es"><![CDATA[IgM]]></kwd>
<kwd lng="en"><![CDATA[DRESS syndrome]]></kwd>
<kwd lng="en"><![CDATA[Incidence]]></kwd>
<kwd lng="en"><![CDATA[Herpes simplex virus]]></kwd>
<kwd lng="en"><![CDATA[Lymphadenopathy]]></kwd>
<kwd lng="en"><![CDATA[Diosmine-herperidin]]></kwd>
<kwd lng="en"><![CDATA[Rash]]></kwd>
<kwd lng="en"><![CDATA[Corticosteroids]]></kwd>
<kwd lng="en"><![CDATA[IgM]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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