<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2448-9190</journal-id>
<journal-title><![CDATA[Revista alergia México]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. alerg. Méx.]]></abbrev-journal-title>
<issn>2448-9190</issn>
<publisher>
<publisher-name><![CDATA[Colegio Mexicano de Inmunología Clínica y Alergia A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2448-91902025000200136</article-id>
<article-id pub-id-type="doi">10.29262/ram.v72i2.1446</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Reacción adversa a medicamentos en una paciente con enfermedad autoinmunitaria: reporte de caso]]></article-title>
<article-title xml:lang="en"><![CDATA[Adverse drug reaction in a patient with autoimmune disease: Case report.]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Castanier-Dávila]]></surname>
<given-names><![CDATA[María Camila]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Wilches-Coronel]]></surname>
<given-names><![CDATA[Paúl Leonardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Médica General.  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Ecuador</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Unidad de Asma y Alergia  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Ecuador</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2025</year>
</pub-date>
<volume>72</volume>
<numero>2</numero>
<fpage>136</fpage>
<lpage>141</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2448-91902025000200136&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2448-91902025000200136&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2448-91902025000200136&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Antecedentes: La reacción adversa a medicamentos es un evento nocivo e involuntario, relacionado con el consumo de fármacos. El Síndrome de Stevens-Johnson es una reacción adversa a medicamentos grave que puede evolucionar a necrólisis epidérmica tóxica, relacionada con ciertos fármacos, incluso puede desencadenarse por infecciones y factores genéticos.  Reporte de caso: Paciente femenina de 62 años, con hipertensión arterial, que manifestó lesiones cutáneas severas luego de automedicarse con paracetamol e ibuprofeno. Después de varios tratamientos e ingresos a la Unidad de cuidados intensivos evolucionó favorablemente.  Conclusión: Es importante identificar de forma oportuna los factores desencadenantes de la reacción adversa a medicamentos, con la intención de intervenir adecuadamente. La administración de corticoides e inmunoglobulina IV sigue discutiéndose. Se requiere atención inmediata para mejorar los resultados clínicos y el tratamiento integral y de esta manera optimizar el desenlace final.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Background: Adverse drug reactions are harmful and unintentional events related to medication use. Stevens-Johnson Syndrome is a serious adverse drug reaction that can progress to toxic epidermal necrolysis and is related to certain medications. It can even be triggered by infections and genetic factors.  Case report: A 62-year-old female patient with high blood pressure developed severe skin lesions after self-medicating with paracetamol and ibuprofen. She recovered favorably after several treatments and admissions to the Intensive Care Unit.  Conclusions: It is important to promptly identify the triggering factors of adverse drug reactions in order to intervene appropriately. The administration of corticosteroids and IV immunoglobulin is still under discussion. Immediate attention is required to improve clinical outcomes and comprehensive treatment, thus optimizing the outcome.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Síndrome de Stevens-Johnson]]></kwd>
<kwd lng="es"><![CDATA[Reacción adversa a medicamentos]]></kwd>
<kwd lng="es"><![CDATA[Necrólisis epidérmica tóxica]]></kwd>
<kwd lng="es"><![CDATA[Lesiones cutáneas]]></kwd>
<kwd lng="es"><![CDATA[Paracetamol]]></kwd>
<kwd lng="es"><![CDATA[Ibuprofeno]]></kwd>
<kwd lng="es"><![CDATA[Costicosteriodes]]></kwd>
<kwd lng="es"><![CDATA[Inmunoglobulina IV]]></kwd>
<kwd lng="en"><![CDATA[Stevens-Johnson Syndrome]]></kwd>
<kwd lng="en"><![CDATA[Adverse drug reactions]]></kwd>
<kwd lng="en"><![CDATA[Toxic epidermal necrolysis]]></kwd>
<kwd lng="en"><![CDATA[Skin lesions]]></kwd>
<kwd lng="en"><![CDATA[Paracetamol]]></kwd>
<kwd lng="en"><![CDATA[Ibuprofen]]></kwd>
<kwd lng="en"><![CDATA[Corticoids]]></kwd>
<kwd lng="en"><![CDATA[IV immunoglobulin]]></kwd>
</kwd-group>
</article-meta>
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