<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2448-9190</journal-id>
<journal-title><![CDATA[Revista alergia México]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. alerg. Méx.]]></abbrev-journal-title>
<issn>2448-9190</issn>
<publisher>
<publisher-name><![CDATA[Colegio Mexicano de Inmunología Clínica y Alergia A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2448-91902024000400268</article-id>
<article-id pub-id-type="doi">10.29262/ram.v71i4.1405</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Neutropenia congénita y enfermedad de injerto contra huésped aguda postrasplante en un lactante. Reporte de caso]]></article-title>
<article-title xml:lang="en"><![CDATA[Congenital neutropenia and acute graft-versus-host disease in an infant. A case report]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Huchim-Peña]]></surname>
<given-names><![CDATA[Cristian Jesús]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Catana-Gallegos]]></surname>
<given-names><![CDATA[Emiliano]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martín-Burgos]]></surname>
<given-names><![CDATA[Nayibe Getsemaní]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pacheco-Sierra]]></surname>
<given-names><![CDATA[Jesús Esteban Ambrosio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Infantil de México Federico Gómez Servicio de Patogénesis Molecular ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Ciudad de México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Autónoma de Yucatán Facultad de Medicina ]]></institution>
<addr-line><![CDATA[Mérida ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Autónoma de Campeche Facultad de Medicina ]]></institution>
<addr-line><![CDATA[Campeche ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2024</year>
</pub-date>
<volume>71</volume>
<numero>4</numero>
<fpage>268</fpage>
<lpage>271</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2448-91902024000400268&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2448-91902024000400268&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2448-91902024000400268&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Antecedentes: La neutropenia congénita es una inmunodeficiencia primaria caracterizada por una disminución en el recuento de neutrófilos. Se clasifica en leve, moderada o grave. Dentro de las opciones de tratamiento se incluye el trasplante de células progenitoras hematopoyéticas; no obstante, la enfermedad de injerto contra huésped supone una complicación importante.  Reporte de caso: Paciente de 2 años de edad, con antecedentes médicos de neutropenia congénita. Cursó con abscesos en la piel cabelluda y celulitis preseptal, tratados satisfactoriamente. Luego de la evaluación multidisciplinaria, se inició el protocolo para recibir trasplante alogénico de células progenitoras hematopoyéticas de donador no relacionado. Se estableció el diagnóstico de enfermedad injerto contra huésped, que complicó el pronóstico y, finalmente, dio como resultado el fallecimiento de la paciente.  Conclusión: La enfermedad injerto contra huésped sigue siendo una complicación importante en pacientes que reciben trasplantes alogénicos de células progenitoras hematopoyéticas. La identificación, abordaje y tratamiento tiene relevancia clínica, debido a la elevada morbilidad y mortalidad asociadas.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Background: Congenital neutropenia is a primary immunodeficiency characterized by quantitative anomalies in neutrophil counts. It is classified as mild, moderate, or severe. Hematopoietic stem cell transplantation stands as a potential therapeutic intervention; nevertheless, graft-versus-host disease emerges as a main complication.  Case report: We report the case of a 2-year-old female patient, with a history of congenital neutropenia. She had scalp abscesses and preseptal cellulitis, which were satisfactorily treated. After a multidisciplinary approach, a protocol was initiated to receive an allogenic hematopoietic progenitor cell transplant; graft versus host disease was subsequently diagnosed, ultimately resulting in death of the patient.  Conclusion: Graft-versus-host disease remains a significant complication in patients who undergo allogeneic hematopoietic stem cell transplants. Its recognition, management, and treatment are clinically relevant aspects given the substantial degree of associated morbidity and mortality.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Neutropenia congénita]]></kwd>
<kwd lng="es"><![CDATA[Trasplante de células progenitoras hematopoyéticas]]></kwd>
<kwd lng="es"><![CDATA[Enfermedad injerto contra huésped]]></kwd>
<kwd lng="en"><![CDATA[Congenital neutropenia]]></kwd>
<kwd lng="en"><![CDATA[Hematopoietic stem cell transplantation]]></kwd>
<kwd lng="en"><![CDATA[Graft-versus-host-disease]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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