<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2448-9190</journal-id>
<journal-title><![CDATA[Revista alergia México]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. alerg. Méx.]]></abbrev-journal-title>
<issn>2448-9190</issn>
<publisher>
<publisher-name><![CDATA[Colegio Mexicano de Inmunología Clínica y Alergia A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2448-91902023000200064</article-id>
<article-id pub-id-type="doi">10.29262/ram.v70i2.1247</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Calidad de vida relacionada con la salud en pacientes con angioedema hereditario de Argentina. Estudio multicéntrico]]></article-title>
<article-title xml:lang="en"><![CDATA[Health related to quality life of patients with hereditary angioedema in Argentina. A multicenter study.]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Medina]]></surname>
<given-names><![CDATA[Iris]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Josviack]]></surname>
<given-names><![CDATA[Darío]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Berardi]]></surname>
<given-names><![CDATA[Alejandro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cavallo]]></surname>
<given-names><![CDATA[Cecilia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Chinigo]]></surname>
<given-names><![CDATA[Marcela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Chorzepa]]></surname>
<given-names><![CDATA[Gonzalo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fueyo]]></surname>
<given-names><![CDATA[Gabriel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García]]></surname>
<given-names><![CDATA[Marcela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Onetti]]></surname>
<given-names><![CDATA[Cora]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vázquez]]></surname>
<given-names><![CDATA[Daniel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Centro Médico Vitae  ]]></institution>
<addr-line><![CDATA[9 de Julio Buenos Aires]]></addr-line>
<country>Argentina</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto de Medicina Respiratoria  ]]></institution>
<addr-line><![CDATA[Rafaela Santa Fe]]></addr-line>
<country>Argentina</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Instituto de Asma Alergia y Enfermedades Respiratorias ]]></institution>
<addr-line><![CDATA[ Corrientes]]></addr-line>
<country>Argentina</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Hospital San Martín  ]]></institution>
<addr-line><![CDATA[Paraná Entre Ríos]]></addr-line>
<country>Argentina</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Hospital Interzonal Especializado de Agudos y Crónicos San Juan de Dios  ]]></institution>
<addr-line><![CDATA[ La Plata]]></addr-line>
<country>Argentina</country>
</aff>
<aff id="Af6">
<institution><![CDATA[,Sanatorio Parque  ]]></institution>
<addr-line><![CDATA[ Rosario]]></addr-line>
<country>Argentina</country>
</aff>
<aff id="Af7">
<institution><![CDATA[,Centro Cardiológico Trelew  ]]></institution>
<addr-line><![CDATA[ Trelew]]></addr-line>
<country>Argentina</country>
</aff>
<aff id="Af8">
<institution><![CDATA[,Hospital Sor María Ludovica  ]]></institution>
<addr-line><![CDATA[ La Plata]]></addr-line>
<country>Argentina</country>
</aff>
<aff id="Af9">
<institution><![CDATA[,Hospital General De Agudos José María Penna  ]]></institution>
<addr-line><![CDATA[ Buenos Aires]]></addr-line>
<country>Argentina</country>
</aff>
<aff id="A10">
<institution><![CDATA[,Clínica Privada Monte Grande  ]]></institution>
<addr-line><![CDATA[ Buenos Aires]]></addr-line>
<country>Argentina</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2023</year>
</pub-date>
<volume>70</volume>
<numero>2</numero>
<fpage>64</fpage>
<lpage>71</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2448-91902023000200064&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2448-91902023000200064&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2448-91902023000200064&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Objetivos: Describir la calidad de vida relacionada con la salud en pacientes adultos, ambulatorios y estables con angioedema hereditario, mediante cuestionarios validados.  Métodos: Estudio descriptivo, transversal y observacional, llevado a cabo en pacientes con angioedema hereditario, procedentes de la Ciudad de Buenos Aires y sus provincias: Corrientes, Chubut, Entre Ríos y Santa Fe. Se aplicaron los cuestionarios HAE-QoL y SF-12v2 para evaluar la calidad de vida relacionada con la salud.  Resultados: Se incluyeron 100 pacientes, con mediana de edad de 41.5 años (rango: 18-77), principalmente de género femenino (65%). La forma más frecuente de angioedema hereditario fue el tipo 1 (79%). Los casos asintomáticos, leves, moderados y severos representaron el 6, 29, 38 y 27%, respectivamente. El 17% recibía profilaxis a largo plazo. Icatibant fue el tratamiento más prescrito para los episodios agudos de angioedema. Todos los puntajes de los dominios de salud del SF-12v2 fueron menores de lo esperado, excepto &#8220;vitalidad&#8221; y &#8220;funcionamiento físico&#8221;. Se observó disminución en los puntajes totales y en todos los dominios del HAEQoL. Se reconocieron diferencias entre las mujeres y los hombres, y para grupo etario en los puntajes de los dominios específicos.  Conclusión: La calidad de vida relacionada con la salud disminuyó considerablemente en pacientes argentinos con angioedema hereditario al aplicar los cuestionarios HAE-QoL y SF-12v2. Es importante desarrollar estrategias multidisciplinarias para abordar esta enfermedad compleja.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Objective: To describe health relaed quality of life in a cohort of stable adult outpatients with hereditary angioedema (HAE) with validated tools.  Methods: An observational, cross-sectional, and descriptive study was performed, carried out in patients with hereditary angioedema, coming from the City of Buenos Aires and its provinces: Corrientes, Chubut, Entre Ríos and Santa Fe. The HAE-QoL and SF-12v2 health questionnaires were applied to assess the related quality of life. with health.  Results: 100 patients were included; median age: 41.5 years (range: 18-77); 65% were female, and 79% had type 1 HAE. Asymptomatic, mild, moderate and severe cases accounted for 6, 29, 38, and 27% of participants, respectively. Seventeen percent of patients were receiving long-term prophylaxis. Icatibant was the most frequent treatment for acute episodes. All health domains SF-12v2 scores were lower than expected in general population, excepting &#8220;vitality&#8221; and &#8220;physical functioning&#8221;. Total and all specific domains HAE-QoL scores were reduced. Differences between women and men and in every age-defined group were demonstrated for several specific domains.  Conclusions: Health relaed to quality life was notably reduced in Argentinean patients with HAE, when implementing the HAE.QoL, and SF-12v2 questionnaries. The need for multidisciplinary strategies approaching this complex disease is highlighted.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Angioedema hereditario]]></kwd>
<kwd lng="es"><![CDATA[calidad de vida relacionada con la salud]]></kwd>
<kwd lng="es"><![CDATA[HAE-QoL]]></kwd>
<kwd lng="es"><![CDATA[SF-12v2]]></kwd>
<kwd lng="es"><![CDATA[Argentina]]></kwd>
<kwd lng="en"><![CDATA[Hereditary angioedema]]></kwd>
<kwd lng="en"><![CDATA[Health-related quality of life]]></kwd>
<kwd lng="en"><![CDATA[HAE-QoL]]></kwd>
<kwd lng="en"><![CDATA[SF-12v2]]></kwd>
<kwd lng="en"><![CDATA[Argentina]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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