<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2448-9190</journal-id>
<journal-title><![CDATA[Revista alergia México]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. alerg. Méx.]]></abbrev-journal-title>
<issn>2448-9190</issn>
<publisher>
<publisher-name><![CDATA[Colegio Mexicano de Inmunología Clínica y Alergia A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2448-91902022000200067</article-id>
<article-id pub-id-type="doi">10.29262/ram.v69i2.1146</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Frecuencia de características clínicas y factores asociados con mortalidad en pacientes hospitalizados por COVID-19 en Puebla, México]]></article-title>
<article-title xml:lang="en"><![CDATA[Frequency of clinical characteristics and factors associated with mortality in patients hospitalized for COVID-19 in Puebla, Mexico]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hernández-Morales]]></surname>
<given-names><![CDATA[María del Rocío]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Maldonado-Castañeda]]></surname>
<given-names><![CDATA[Sandra]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mancilla-Hernández]]></surname>
<given-names><![CDATA[Eleazar]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Amaro-Zarate]]></surname>
<given-names><![CDATA[Irving]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Aguirre-Barbosa]]></surname>
<given-names><![CDATA[Margarita]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Nazarala-Sanchez]]></surname>
<given-names><![CDATA[Samara]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital General Dr. Eduardo Vázquez N  ]]></institution>
<addr-line><![CDATA[ Puebla]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital General Dr. Eduardo Vázquez N  ]]></institution>
<addr-line><![CDATA[ Puebla]]></addr-line>
<country>México</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Centro de Investigación en el Área de la Salud  ]]></institution>
<addr-line><![CDATA[ Puebla]]></addr-line>
<country>México</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Secretaria de Salud del Estado de Puebla  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Secretaria de Salud del Estado de Puebla  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2022</year>
</pub-date>
<volume>69</volume>
<numero>2</numero>
<fpage>67</fpage>
<lpage>71</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2448-91902022000200067&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2448-91902022000200067&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2448-91902022000200067&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Objetivo:  Identificar los factores de riesgo y las manifestaciones clínicas asociadas con mortalidad por COVID-19 en pacientes internados en hospitales de la Secretaria de Salud (SSA) del estado de Puebla, México.  Material y Métodos:  Estudio observacional, retrospectivo y transversal, llevado a cabo en pacientes con COVID-19, internados en hospitales de la Secretaria de Salud (SSA) del estado de Puebla, México. Los pacientes se dividieron en dos grupos: 1) fallecidos por COVID-19 y 2) supervivientes de COVID-19.  Resultados:  Se registraron 502 pacientes: 314 hombres (62.5 % IC95% 58-66 %) y 188 mujeres (37.5% IC95% 33-42%), con edad promedio de 54.14 ± 13.8 años (rango intercuartil de 45-63, intervalo de edad de 19 y 90 años); estancia hospitalaria de 1 a 43 días (media 9.8 ± 7.8 días, mediana 8, rango intercuartil 4-13 días). Los síntomas asociados con mortalidad por COVID-19 fueron: disnea y dolor torácico (RM &gt;1). Las variables asociadas con mortalidad: edad igual o mayor de 65 años, estancia hospitalaria prolongada, coexistencia de dos o más comorbilidades (RM: 1.453), diabetes (RM: 1.759), hipertensión (RM: 6.29) e insuficiencia renal crónica (RM: 3.16; p&lt;0.05); ferritina &gt;500 ng/mL (RM: 5.1799), DHL &gt;400 IU/L (RM: 3.313) y Dimero D &gt;2000 m/ml (RM: 2.868)  Conclusiones:  Este estudio demuestra que los principales factores de riesgo asociados con mortalidad por COVID-19 son: edad igual o mayor de 65 años, estancia hospitalaria prolongada, coexistencia de dos o más enfermedades, diabetes, hipertensión e insuficiencia renal crónica; además de concentraciones elevadas de ferritina, Dimero D y DHL.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Background:  Mexico has a very high mortality rate from COVID19, risk factors, clinical manifestations of our population are unknown.  Objective:  To know risk factors for mortality from COVID19 in hospitalized patients of the Secretary of Health (SSA) Puebla, and clinical characteristics.  Material and Methods:  Case-control, observational, retrospective, cross-sectional study in COVID-19 patients. 2 groups: COVID-19 patients who died and those who did not die.  Results:  502 patients, 314 men (62.5% CI95% 58-66%), 188 women (37.5% CI95% 33-42%), mean age 54.14 +13.8, interquartile range (IQR) 45-63, age interval 19 and 90 years, hospital stay (DEIH) 1-43 days, mean 9.8+7.8 days, median 8, IQR 4-13 days. Symptoms associated with mortality: dyspnea, chest pain, MR&gt;1. Variables associated with mortality: age = or &gt; 65 years, greater IHD, having &gt; 2 comorbidities (OR 1.453), diabetes (OR 1.759), hypertension (OR 6.29) and chronic kidney failure (CRF) (OR 3.16) , (p&lt;0.05). Ferritin &gt;500ng/ml (OR 5.1799), DHL &gt;400 IU/L (OR 3.313) and D-dimer &gt;2000 m/ml (OR 2.868).  Conclusions:  Age &gt; or = 65 years, greater IHD, &gt; 2 comorbidities, diabetes, hypertension or CRF, increased ferritin, D-dimer or DHL, are risk factors for mortality from COVID-19.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Coronavirus]]></kwd>
<kwd lng="en"><![CDATA[SARS-CoV-2]]></kwd>
<kwd lng="en"><![CDATA[COVID-19]]></kwd>
<kwd lng="en"><![CDATA[Mortality]]></kwd>
<kwd lng="en"><![CDATA[Risk factors]]></kwd>
<kwd lng="es"><![CDATA[Coronavirus]]></kwd>
<kwd lng="es"><![CDATA[SARS-CoV-2]]></kwd>
<kwd lng="es"><![CDATA[COVID-19]]></kwd>
<kwd lng="es"><![CDATA[Mortalidad]]></kwd>
<kwd lng="es"><![CDATA[Factores de riesgo]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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