<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2448-9190</journal-id>
<journal-title><![CDATA[Revista alergia México]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. alerg. Méx.]]></abbrev-journal-title>
<issn>2448-9190</issn>
<publisher>
<publisher-name><![CDATA[Colegio Mexicano de Inmunología Clínica y Alergia A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2448-91902017000400505</article-id>
<article-id pub-id-type="doi">10.29262/ram.v64i4.312</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Reacción alérgica tardía a amlodipino con positividad de la prueba de transformación de linfocitos]]></article-title>
<article-title xml:lang="en"><![CDATA[Delayed allergic reaction to amlodipine with a positive lymphocyte transformation test]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Monge-Ortega]]></surname>
<given-names><![CDATA[Olga Patricia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Domínguez-Ortega]]></surname>
<given-names><![CDATA[Javier]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González-Muñoz]]></surname>
<given-names><![CDATA[Miguel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cabañas]]></surname>
<given-names><![CDATA[Rosario]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Lluch-Bernal]]></surname>
<given-names><![CDATA[Magdalena]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fiandor]]></surname>
<given-names><![CDATA[Ana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bravo-Gallego]]></surname>
<given-names><![CDATA[Luz Yadira]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Quirce]]></surname>
<given-names><![CDATA[Santiago]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital San Juan de Dios Departamento de Alergia ]]></institution>
<addr-line><![CDATA[San José ]]></addr-line>
<country>Costa Rica</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital La Paz Departamento de Alergia ]]></institution>
<addr-line><![CDATA[Madrid ]]></addr-line>
<country>España</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Red de Enfermedades Respiratorias Centro de Investigación Biomédica ]]></institution>
<addr-line><![CDATA[Madrid ]]></addr-line>
<country>España</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Consorcio PielenRED  ]]></institution>
<addr-line><![CDATA[Madrid ]]></addr-line>
<country>España</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Hospital La Paz Departamento de Inmunología ]]></institution>
<addr-line><![CDATA[Madrid ]]></addr-line>
<country>España</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2017</year>
</pub-date>
<volume>64</volume>
<numero>4</numero>
<fpage>505</fpage>
<lpage>508</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2448-91902017000400505&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2448-91902017000400505&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2448-91902017000400505&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Antecedentes: el amlodipino es uno de los bloqueadores de los canales de calcio de dihidropiridinas de tercera generación utilizado para la hipertensión. Se han notificado reacciones leves, moderadas y graves con bloqueadores de los canales de calcio. No se ha establecido la reactividad cruzada entre estos fármacos.  Caso clínico: se presenta el caso de una paciente con exantema cutáneo maculopapular, eritematoso y pruriginoso tardío tras la ingestión de amlodipino. La prueba de transformación de linfocitos mostró positividad al amlodipino, lo que confirmó la implicación de este fármaco en la reacción; también mostró positividad al nifedipino, lo que demostró la presencia de reactividad cruzada.  Conclusión: este es el primer caso reportado de hipersensibilidad a amlodipino en el que se confirma la implicación del fármaco por medio de una prueba positiva de transformación de linfocitos, la cual podría convertirse en una buena opción diagnóstica en aquellos pacientes que experimentan reacciones tardías al amlodipino, así como posible reactividad cruzada con nifedipino.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Background: Amlodipine is one of the third generation dihydropyridine calcium channel blockers used for hypertension. Mild, moderate and severe reactions have been reported with calcium channel blockers. Cross-reactivity among these drugs has not been established.  Case report: We have presented the case of a patient who developed a delayed pruritic, and erythematous maculopapular skin exanthema after the intake of amlodipine. A positive lymphocyte transformation test (LTT) confirmed the implication of amlodipine in the reaction and showed positivity to another calcium channel blocker, nifedipine, demonstrating cross reactivity.  Conclusion: This is the first reported case of hypersensitivity to amlodipine in which the involvement of the drug is confirmed by a positive TTL. TTL could become a good diagnostic alternative for patients who experience late reactions to amlodipine and possibly cross-reactivity with nifedipine.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Alergia]]></kwd>
<kwd lng="es"><![CDATA[Amlodipino]]></kwd>
<kwd lng="es"><![CDATA[Reacción tardía]]></kwd>
<kwd lng="es"><![CDATA[Prueba de transformación linfocitaria]]></kwd>
<kwd lng="en"><![CDATA[Allergy]]></kwd>
<kwd lng="en"><![CDATA[Amlodipine]]></kwd>
<kwd lng="en"><![CDATA[Delayed reaction]]></kwd>
<kwd lng="en"><![CDATA[Lymphocyte transformation test]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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