<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2448-9190</journal-id>
<journal-title><![CDATA[Revista alergia México]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. alerg. Méx.]]></abbrev-journal-title>
<issn>2448-9190</issn>
<publisher>
<publisher-name><![CDATA[Colegio Mexicano de Inmunología Clínica y Alergia A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2448-91902017000400499</article-id>
<article-id pub-id-type="doi">10.29262/ram.v64i4.329</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Infección diseminada por complejo M. tuberculosis en paciente con deficiencia completa del receptor 1 de interferón-&#947;]]></article-title>
<article-title xml:lang="en"><![CDATA[Disseminated infection by M. tuberculosis complex in patient with IFN-&#947; receptor 1 complete deficiency]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martínez-Morales]]></surname>
<given-names><![CDATA[María Cecilia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Deswarte]]></surname>
<given-names><![CDATA[Carolina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Castañeda-Casimiro]]></surname>
<given-names><![CDATA[Jessica]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bustamante]]></surname>
<given-names><![CDATA[Jacinta]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Blancas-Galicia]]></surname>
<given-names><![CDATA[Lizbeth]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Scheffler-Mendoza]]></surname>
<given-names><![CDATA[Selma]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Secretaría de Salud Instituto Nacional de Pediatría Servicio de Inmunología]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad París Descartes Instituto de Enfermedades Genéticas ]]></institution>
<addr-line><![CDATA[París ]]></addr-line>
<country>Francia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Instituto Politécnico Nacional Escuela Nacional de Ciencias Biológicas ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Hospital Necker-Niños Enfermos Centro de Estudios de Deficiencias Inmunes ]]></institution>
<addr-line><![CDATA[París ]]></addr-line>
<country>Francia</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Unidad de Investigación en Inmunodeficiencias Instituto Nacional de Pediatría Secretaría de Salud]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2017</year>
</pub-date>
<volume>64</volume>
<numero>4</numero>
<fpage>499</fpage>
<lpage>504</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2448-91902017000400499&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2448-91902017000400499&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2448-91902017000400499&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Antecedentes: Se han descrito diversas mutaciones que llevan a inmunidad alterada en el eje interleucina 12/interferón gamma (IL-12/IFN-&#947;) y confieren susceptibilidad a infecciones por micobacterias. Uno de los fenotipos clínicos más graves es secundario a mutaciones en el gen del receptor 1 de IFN-&#947;, caracterizado por su inicio a temprana edad y mayor gravedad.  Caso clínico: Paciente femenina de 3 meses de edad, con afección sistémica por complejo M. tuberculosis, en quien se identificó una mutación homocigota que afecta el sitio de splicing a nivel de IFNGR1 c.201-1G&gt;T. Al momento de este reporte es manejada con antifímicos en un protocolo de trasplante de células hematopoyéticas pluripotenciales.  Conclusión: Se ha informado que el tratamiento antifímico debe mantenerse hasta que se restaure el sistema inmunológico mediante trasplante de células hematopoyéticas pluripotenciales, cuyo mejor pronóstico se asocia con edad del receptor menor a un año y reducción de los niveles plasmáticos de IFN-&#947;.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Background: Several mutations have been described leading to impaired immunity in the IL-12/IFN-&#947; axis and, they confer susceptibility to mycobacterial infections. One of the more serious clinical phenotypes is secondary to mutations at IFN-&#947; receptor 1 gene, characterized by an early onset and more severe disease.  Case report: We present a 3-month-old female patient with systemic M. tuberculosis complex who has a homozygous mutation, it affects the splicing site at IFNGR1 c.201-1G&gt; T. At time of this report, she is with antimycobacterial treatment in the protocol of pluripotent hematopoietic cell transplantation (TCHP).  Conclusion: It has been reported that antiphimic treatment should be maintained until the immune system is restored by the TCHP. If patients receive THCP before the age of 1 year old, they have a better prognosis. Diminish the levels of IFN-&#947; in plasma before the procedure is associated to better results.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Deficiencia de receptor 1 de IFN-&#947;]]></kwd>
<kwd lng="es"><![CDATA[Micobacteria]]></kwd>
<kwd lng="es"><![CDATA[BCG]]></kwd>
<kwd lng="es"><![CDATA[Inmunodeficiencia primaria]]></kwd>
<kwd lng="es"><![CDATA[Trasplante de médula óssea]]></kwd>
<kwd lng="en"><![CDATA[IFN-&#947;R1 deficiency]]></kwd>
<kwd lng="en"><![CDATA[Mycobacteria]]></kwd>
<kwd lng="en"><![CDATA[BCG]]></kwd>
<kwd lng="en"><![CDATA[Primary immunodeficiency]]></kwd>
<kwd lng="en"><![CDATA[Bone marrow transplantation]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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