<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2448-9190</journal-id>
<journal-title><![CDATA[Revista alergia México]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. alerg. Méx.]]></abbrev-journal-title>
<issn>2448-9190</issn>
<publisher>
<publisher-name><![CDATA[Colegio Mexicano de Inmunología Clínica y Alergia A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2448-91902017000300327</article-id>
<article-id pub-id-type="doi">10.29262/ram.v64i3.263</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Inmunopatología de la enfermedad pulmonar obstructiva crónica]]></article-title>
<article-title xml:lang="en"><![CDATA[Immunopathology of chronic obstructive pulmonary disease]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martínez-Aguilar]]></surname>
<given-names><![CDATA[Nora Ernestina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vargas-Camaño]]></surname>
<given-names><![CDATA[María Eugenia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hernández-Pliego]]></surname>
<given-names><![CDATA[Rogelio Ramsés]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Chaia-Semerena]]></surname>
<given-names><![CDATA[Genny Margarita]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pérez-Chavira]]></surname>
<given-names><![CDATA[María del Rosario]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Centro Médico Coyoacán Servicio de Pediatría, Inmunología Clínica y Alergia ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto de Seguridad Servicios Sociales de los Trabajadores del Estado Centro Médico Nacional 20 de Noviembre, Inmunología Clínica y Alergia]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Astra-Zeneca, Neumología, Investigación Clínica  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Astra-Zeneca, Inmunología Clínica y Alergia  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,aff5  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2017</year>
</pub-date>
<volume>64</volume>
<numero>3</numero>
<fpage>327</fpage>
<lpage>346</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2448-91902017000300327&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2448-91902017000300327&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2448-91902017000300327&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La enfermedad pulmonar obstructiva crónica (EPOC) es una enfermedad común, prevenible y tratable que presenta una fisiopatología compleja y un proceso inmunopatológico aún más complicado. El objetivo de esta revisión fue analizar los aspectos inmunopatológicos de la EPOC, para lo cual se llevó a una cabo una pesquisa bibliográfica de los documentos más relevantes indexados en la base de datos PubMed durante los últimos 10 años. Diversos aspectos pudieron concluirse: en la inmunopatología de la EPOC existen cambios inflamatorios, inmunológicos y no inmunológicos con un desequilibrio en el estrés oxidativo, así como alteraciones en la relación proteasas/antiproteasas debidas a efectos genéticos, epigenéticos, ambientales directos e indirectos. La EPOC produce daño tisular irreversible e inflamación crónica con alteración de la reparación tisular que induce obstrucción crónica de la vía aérea, bronquitis, enfisema y daño sistémico. Las comorbilidades resultantes más comunes son enfermedad cardiovascular, síndrome metabólico, osteoporosis, depresión, disfunción músculo esquelética, incremento de la edad biológica, cáncer pulmonar y otros tipos de neoplasias. En la concepción de la EPOC es indispensable reconocer que es una enfermedad no transmisible y prevenible.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Chronic obstructive pulmonary disease (COPD) is a common, preventable and treatable condition that has a complex pathophysiology and an even more complex immunopathological process. The purpose of this review was to analyze COPD immunopathological aspects, which was addressed by undertaking a literature search for the most relevant documents indexed in the PubMed database over the last 10 years. Different conclusions could be drawn: in COPD immunopathology there are immune and non-immune inflammatory changes with oxidative stress imbalance, there are alterations in the protease/anti-protease ratio caused by direct and indirect genetic and epigenetic-environmental defects; COPD produces irreversible tissue damage and chronic inflammation with tissue repair alteration, which induces chronic obstruction of the airway, bronchitis and systemic damage. Most common resulting comorbidities include cardiovascular disease, metabolic syndrome, osteoporosis, depression, musculoskeletal dysfunction, increased biological age, lung cancer and other types of malignancies. In the conception of COPD, recognizing that it is a non-transmittable and preventable disease is indispensable.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Enfermedad pulmonar obstructiva crónica]]></kwd>
<kwd lng="es"><![CDATA[Inflamación]]></kwd>
<kwd lng="en"><![CDATA[Chronic obstructive pulmonary disease]]></kwd>
<kwd lng="en"><![CDATA[Inflammation]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="book">
<collab>Global Initiative for Chronic Obstructive Lung Disease</collab>
<source><![CDATA[Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease (Update 2016)]]></source>
<year>2016</year>
<publisher-name><![CDATA[Global Initiative for Chronic Obstructive Lung Disease]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Guías para el diagnóstico y tratamiento de la enfermedad pulmonar obstructiva crónica. Derivadas del cuarto consenso mexicano para el diagnóstico y tratamiento de la EPOC]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sansores]]></surname>
<given-names><![CDATA[RH]]></given-names>
</name>
<name>
<surname><![CDATA[Ramírez-Venegas]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Acuña]]></surname>
<given-names><![CDATA[KM]]></given-names>
</name>
<name>
<surname><![CDATA[Arango]]></surname>
<given-names><![CDATA[RAA]]></given-names>
</name>
<name>
<surname><![CDATA[Argote-Greene]]></surname>
<given-names><![CDATA[LM]]></given-names>
</name>
<name>
<surname><![CDATA[Cante]]></surname>
<given-names><![CDATA[FEV]]></given-names>
</name>
</person-group>
<source><![CDATA[Neumol Cir Torax]]></source>
<year>2012</year>
<volume>71</volume>
<numero>^sSupl 1</numero>
<issue>^sSupl 1</issue>
<supplement>Supl 1</supplement>
<page-range>8-89</page-range></nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[From COPD definitions to COPD phenotypes]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Burgel]]></surname>
<given-names><![CDATA[PR]]></given-names>
</name>
</person-group>
<source><![CDATA[Presse Med]]></source>
<year>2014</year>
<volume>43</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>1337-43</page-range></nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Clinically relevant subgroups in COPD and asthma]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Turner]]></surname>
<given-names><![CDATA[AM]]></given-names>
</name>
<name>
<surname><![CDATA[Tamasi]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Schleich]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Hoxha]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Horvath]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Louis]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<source><![CDATA[Eur Respir Rev]]></source>
<year>2015</year>
<volume>24</volume>
<numero>136</numero>
<issue>136</issue>
<page-range>283-98</page-range></nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Chronic bronchitis and chronic obstructive pulmonary disease]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Criner]]></surname>
<given-names><![CDATA[GJ]]></given-names>
</name>
</person-group>
<source><![CDATA[Am J Respir Crit Care Med]]></source>
<year>2013</year>
<volume>187</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>228-37</page-range></nlm-citation>
</ref>
<ref id="B6">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Expert consensus on acute exacerbation of chronic obstructive pulmonary disease in the People's Republic of China]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cai]]></surname>
<given-names><![CDATA[BQ]]></given-names>
</name>
<name>
<surname><![CDATA[Cai]]></surname>
<given-names><![CDATA[SX]]></given-names>
</name>
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[RC]]></given-names>
</name>
<name>
<surname><![CDATA[Cui]]></surname>
<given-names><![CDATA[LY]]></given-names>
</name>
<name>
<surname><![CDATA[Feng]]></surname>
<given-names><![CDATA[YL]]></given-names>
</name>
<name>
<surname><![CDATA[Gu]]></surname>
<given-names><![CDATA[YT]]></given-names>
</name>
</person-group>
<source><![CDATA[Int J Chron Obstruct Pulmon Dis]]></source>
<year>2014</year>
<volume>9</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>381-95</page-range></nlm-citation>
</ref>
<ref id="B7">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Long-term exposure to ambient air pollution and mortality due to cardiovascular disease and cerebrovascular disease in Shenyang, China]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Dong]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Sun]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Ma]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
</person-group>
<source><![CDATA[PLoS One]]></source>
<year>2011</year>
<volume>6</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>e20827</page-range></nlm-citation>
</ref>
<ref id="B8">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[An official American Thoracic Society/European Respiratory Society statement: Update on limb muscle dysfunction in chronic obstructive pulmonary disease]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Maltais]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Decramer]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Casaburi]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Barreiro]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Burelle]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Debigaré]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<source><![CDATA[Am J Respir Crit Care Med]]></source>
<year>2014</year>
<volume>189</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>e15-62</page-range></nlm-citation>
</ref>
<ref id="B9">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[COPD: Balancing oxidants and antioxidants]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fischer]]></surname>
<given-names><![CDATA[BM]]></given-names>
</name>
<name>
<surname><![CDATA[Voynow]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Ghio]]></surname>
<given-names><![CDATA[AJ]]></given-names>
</name>
</person-group>
<source><![CDATA[Int J Chron Obstruct Pulmon Dis]]></source>
<year>2015</year>
<volume>10</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>261-76</page-range></nlm-citation>
</ref>
<ref id="B10">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Cytokine inhibition in the treatment of COPD]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Caramori]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Adcock]]></surname>
<given-names><![CDATA[IM]]></given-names>
</name>
<name>
<surname><![CDATA[Di Stefano]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Chung]]></surname>
<given-names><![CDATA[KF]]></given-names>
</name>
</person-group>
<source><![CDATA[Int J Chron Obstruct Pulmon Dis]]></source>
<year>2014</year>
<volume>9</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>397-412</page-range></nlm-citation>
</ref>
<ref id="B11">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Airway mucus function and dysfunction]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fahy]]></surname>
<given-names><![CDATA[JV]]></given-names>
</name>
<name>
<surname><![CDATA[Dickey]]></surname>
<given-names><![CDATA[BF]]></given-names>
</name>
</person-group>
<source><![CDATA[N Engl J Med.]]></source>
<year>2010</year>
<volume>363</volume>
<numero>23</numero>
<issue>23</issue>
<page-range>2233-47</page-range></nlm-citation>
</ref>
<ref id="B12">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The presence of chronic mucus hypersecretion across adult life in relation to chronic obstructive pulmonary disease development]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Allinson]]></surname>
<given-names><![CDATA[JP]]></given-names>
</name>
<name>
<surname><![CDATA[Hardy]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Donaldson]]></surname>
<given-names><![CDATA[GC]]></given-names>
</name>
<name>
<surname><![CDATA[Shaheen]]></surname>
<given-names><![CDATA[SO]]></given-names>
</name>
<name>
<surname><![CDATA[Kuh]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Wedzicha]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
</person-group>
<source><![CDATA[Am J Respir Crit Care Med]]></source>
<year>2016</year>
<volume>193</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>662-72</page-range></nlm-citation>
</ref>
<ref id="B13">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The definition of emphysema: Report of a National Heart, Lung, and Blood Institute, Division of Lung Diseases workshop]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Snider]]></surname>
<given-names><![CDATA[GL]]></given-names>
</name>
<name>
<surname><![CDATA[Kleinerman]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Thurlbeck]]></surname>
<given-names><![CDATA[WM]]></given-names>
</name>
<name>
<surname><![CDATA[Bengali]]></surname>
<given-names><![CDATA[ZH]]></given-names>
</name>
</person-group>
<source><![CDATA[Am Rev Respir Dis]]></source>
<year>1985</year>
<volume>132</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>182-5</page-range></nlm-citation>
</ref>
<ref id="B14">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Pathogenesis of chronic obstructive pulmonary disease]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[MacNee]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
</person-group>
<source><![CDATA[Proc Am Thorac Soc]]></source>
<year>2005</year>
<volume>2</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>258-66</page-range></nlm-citation>
</ref>
<ref id="B15">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Dysfunctional lung anatomy and small airways degeneration in COPD]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Martin]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Frija]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Burgel]]></surname>
<given-names><![CDATA[PR]]></given-names>
</name>
</person-group>
<source><![CDATA[Int J Chron Obstruct Pulmon Dis]]></source>
<year>2013</year>
<volume>8</volume>
<page-range>7-13</page-range></nlm-citation>
</ref>
<ref id="B16">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Novel aspects of pathogenesis and regeneration mechanisms in COPD]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bagdonas]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Raudoniute]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Bruzauskaite]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Aldonyte]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<source><![CDATA[Int J Chron Obstruct Pulmon Dis]]></source>
<year>2015</year>
<volume>10</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>995-1013</page-range></nlm-citation>
</ref>
<ref id="B17">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Long-term exposure to traffic emissions and fine particulate matter and lung function decline in the Framingham heart study]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rice]]></surname>
<given-names><![CDATA[MB]]></given-names>
</name>
<name>
<surname><![CDATA[Ljungman]]></surname>
<given-names><![CDATA[PL]]></given-names>
</name>
<name>
<surname><![CDATA[Wilker]]></surname>
<given-names><![CDATA[EH]]></given-names>
</name>
<name>
<surname><![CDATA[Dorans]]></surname>
<given-names><![CDATA[KS]]></given-names>
</name>
<name>
<surname><![CDATA[Gold]]></surname>
<given-names><![CDATA[DR]]></given-names>
</name>
<name>
<surname><![CDATA[Schwartz]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<source><![CDATA[Am J Respir Crit Care Med]]></source>
<year>2015</year>
<volume>191</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>656-64</page-range></nlm-citation>
</ref>
<ref id="B18">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Neural respiratory drive measurement for COPD assessment and monitoring]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Garland]]></surname>
<given-names><![CDATA[AJ]]></given-names>
</name>
<name>
<surname><![CDATA[Doshi]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Turcanu]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
</person-group>
<source><![CDATA[Pneumologia]]></source>
<year>2015</year>
<volume>64</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>14-7</page-range></nlm-citation>
</ref>
<ref id="B19">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Smoking-induced skeletal muscle dysfunction: From evidence to mechanisms]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Degens]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Gayan-Ramirez]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Van-Hees]]></surname>
<given-names><![CDATA[HW]]></given-names>
</name>
</person-group>
<source><![CDATA[Am J Respir Crit Care Med]]></source>
<year>2015</year>
<volume>191</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>620-5</page-range></nlm-citation>
</ref>
<ref id="B20">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The role of microparticles in chronic obstructive pulmonary disease]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Takahashi]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Kubo]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<source><![CDATA[Int J Chron Obstruct Pulmon Dis]]></source>
<year>2014</year>
<volume>9</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>303-14</page-range></nlm-citation>
</ref>
<ref id="B21">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Challenge models to assess new therapies in chronic obstructive pulmonary disease]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Van-Der-Merwe]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Molfino]]></surname>
<given-names><![CDATA[NA]]></given-names>
</name>
</person-group>
<source><![CDATA[Int J Chron Obstruct Pulmon Dis]]></source>
<year>2012</year>
<volume>7</volume>
<page-range>597-605</page-range></nlm-citation>
</ref>
<ref id="B22">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[NF-kappaB signaling in chronic inflammatory airway disease]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Schuliga]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[Biomolecules]]></source>
<year>2015</year>
<volume>5</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>1266-83</page-range></nlm-citation>
</ref>
<ref id="B23">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[A panoramic spectrum of complex interplay between the immune system and IL-32 during pathogenesis of various systemic infections and inflammation]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Khawar]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Abbasi]]></surname>
<given-names><![CDATA[MH]]></given-names>
</name>
<name>
<surname><![CDATA[Nadeem Sheikh]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
</person-group>
<source><![CDATA[Eur J Med Res]]></source>
<year>2015</year>
<volume>20</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>7</page-range></nlm-citation>
</ref>
<ref id="B24">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Dysfunctional lung anatomy and small airways degeneration in COPD]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Martin]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Frija]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Burgel]]></surname>
<given-names><![CDATA[PR]]></given-names>
</name>
</person-group>
<source><![CDATA[Int J Chron Obstruct Pulmon Dis]]></source>
<year>2013</year>
<volume>8</volume>
<page-range>7-13</page-range></nlm-citation>
</ref>
<ref id="B25">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Origin and functions of tissue macrophages]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Epelman]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Lavine]]></surname>
<given-names><![CDATA[KJ]]></given-names>
</name>
<name>
<surname><![CDATA[Randolph]]></surname>
<given-names><![CDATA[GJ]]></given-names>
</name>
</person-group>
<source><![CDATA[Immunity]]></source>
<year>2014</year>
<volume>41</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>21-35</page-range></nlm-citation>
</ref>
<ref id="B26">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Macrophage heterogeneity in tissues: Phenotypic diversity and functions]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gordon]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Plüddemann]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Martinez-Estrada]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<source><![CDATA[Immunol Rev]]></source>
<year>2014</year>
<volume>262</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>36-55</page-range></nlm-citation>
</ref>
<ref id="B27">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Inflammatory mechanisms in patients with chronic obstructive pulmonary disease]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Barnes]]></surname>
<given-names><![CDATA[PJ]]></given-names>
</name>
</person-group>
<source><![CDATA[J Allergy Clin Immunol]]></source>
<year>2016</year>
<volume>138</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>16-27</page-range></nlm-citation>
</ref>
<ref id="B28">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Levels of IL-32 in serum, induced sputum supernatant, and bronchial lavage fluid of patients with chronic obstructive pulmonary disease]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gasiuniene]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Lavinskiene]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Sakalauskas]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Sitkauskiene]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<source><![CDATA[COPD]]></source>
<year>2016</year>
<volume>13</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>569-75</page-range></nlm-citation>
</ref>
<ref id="B29">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Directing traffic: IL-17 and IL-22 coordinate pulmonary immune defense]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[McAleer]]></surname>
<given-names><![CDATA[JP]]></given-names>
</name>
<name>
<surname><![CDATA[Kolls]]></surname>
<given-names><![CDATA[JK]]></given-names>
</name>
</person-group>
<source><![CDATA[Immunol Rev]]></source>
<year>2014</year>
<volume>260</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>129-44</page-range></nlm-citation>
</ref>
<ref id="B30">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Infection in the pathogenesis and course of chronic obstructive pulmonary disease]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sethi]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Murphy]]></surname>
<given-names><![CDATA[TF]]></given-names>
</name>
</person-group>
<source><![CDATA[N Engl J Med]]></source>
<year>2008</year>
<volume>359</volume>
<numero>22</numero>
<issue>22</issue>
<page-range>2355-65</page-range></nlm-citation>
</ref>
<ref id="B31">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The nature of small-airway obstruction in chronic obstructive pulmonary disease]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hogg]]></surname>
<given-names><![CDATA[JC]]></given-names>
</name>
<name>
<surname><![CDATA[Chu]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Utokaparch]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Woods]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Elliott]]></surname>
<given-names><![CDATA[WM]]></given-names>
</name>
<name>
<surname><![CDATA[Buzatu]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<source><![CDATA[N Engl J Med]]></source>
<year>2004</year>
<volume>350</volume>
<numero>26</numero>
<issue>26</issue>
<page-range>2645-53</page-range></nlm-citation>
</ref>
<ref id="B32">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Lymphocyte senescence in COPD is associated with loss of glucocorticoid receptor expression by pro-inflammatory/cytotoxic lymphocytes]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hodge]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Jersmann]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Tran]]></surname>
<given-names><![CDATA[HB]]></given-names>
</name>
<name>
<surname><![CDATA[Holmes]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Reynolds]]></surname>
<given-names><![CDATA[PN]]></given-names>
</name>
<name>
<surname><![CDATA[Hodge]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<source><![CDATA[Respir Res]]></source>
<year>2015</year>
<volume>16</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>2</page-range></nlm-citation>
</ref>
<ref id="B33">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Immunologic aspects of chronic obstructive pulmonary disease]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cosío]]></surname>
<given-names><![CDATA[MG]]></given-names>
</name>
<name>
<surname><![CDATA[Saetta]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Agusti]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<source><![CDATA[N Engl J Med]]></source>
<year>2009</year>
<volume>360</volume>
<numero>23</numero>
<issue>23</issue>
<page-range>2396-454</page-range></nlm-citation>
</ref>
<ref id="B34">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[CD8+ T-lymphocytes in peripheral airways of smokers with chronic obstructive pulmonary disease]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Saetta]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Di-Stefano]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Turato]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Facchini]]></surname>
<given-names><![CDATA[FM]]></given-names>
</name>
<name>
<surname><![CDATA[Corbino]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Mapp]]></surname>
<given-names><![CDATA[CE]]></given-names>
</name>
</person-group>
<source><![CDATA[Am J Respir Crit Care Med]]></source>
<year>1998</year>
<volume>157</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>822-6</page-range></nlm-citation>
</ref>
<ref id="B35">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Inflammation and immune response in COPD: Where do we stand]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rovina]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Koutsoukou]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Koulouris]]></surname>
<given-names><![CDATA[NG]]></given-names>
</name>
</person-group>
<source><![CDATA[Mediators Inflamm]]></source>
<year>2013</year>
</nlm-citation>
</ref>
<ref id="B36">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The drug efflux pump Pgp1 in pro-inflammatory lymphocytes is a target for novel treatment strategies in COPD]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hodge]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Holmes]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Jersmann]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Reynolds]]></surname>
<given-names><![CDATA[PN]]></given-names>
</name>
<name>
<surname><![CDATA[Hodge]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<source><![CDATA[Respir Res]]></source>
<year>2013</year>
<volume>14</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>63</page-range></nlm-citation>
</ref>
<ref id="B37">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The non-neuronal cholinergic system in the airways: An unappreciated regulatory role in pulmonary inflammation]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gwilt]]></surname>
<given-names><![CDATA[CR]]></given-names>
</name>
<name>
<surname><![CDATA[Donnelly]]></surname>
<given-names><![CDATA[LE]]></given-names>
</name>
<name>
<surname><![CDATA[Rogers]]></surname>
<given-names><![CDATA[DF]]></given-names>
</name>
</person-group>
<source><![CDATA[Pharmacol Ther]]></source>
<year>2007</year>
<volume>115</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>208-22</page-range></nlm-citation>
</ref>
<ref id="B38">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Regulation of airway inflammation and remodeling by muscarinic receptors: Perspectives on anticholinergic therapy in asthma and COPD]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kistemaker]]></surname>
<given-names><![CDATA[LE]]></given-names>
</name>
<name>
<surname><![CDATA[Oenema]]></surname>
<given-names><![CDATA[TA]]></given-names>
</name>
<name>
<surname><![CDATA[Meurs]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Gosens]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<source><![CDATA[Life Sci]]></source>
<year>2012</year>
<volume>91</volume>
<numero>21-22</numero>
<issue>21-22</issue>
<page-range>1126-33</page-range></nlm-citation>
</ref>
<ref id="B39">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Increased levels of Th17 cells are associated with non-neuronal acetylcholine in COPD patients]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Profita]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Albano]]></surname>
<given-names><![CDATA[GD]]></given-names>
</name>
<name>
<surname><![CDATA[Riccobono]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Di-Sano]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Montalbano]]></surname>
<given-names><![CDATA[AM]]></given-names>
</name>
<name>
<surname><![CDATA[Gagliardo]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<source><![CDATA[Immunobiology]]></source>
<year>2014</year>
<volume>219</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>392-401</page-range></nlm-citation>
</ref>
<ref id="B40">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[CXCL13 production in B cells via Toll-like receptor/lymphotoxin receptor signaling is involved in lymphoid neogenesis in chronic obstructive pulmonary disease]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Litsiou]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Semitekolou]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Galani]]></surname>
<given-names><![CDATA[IE]]></given-names>
</name>
<name>
<surname><![CDATA[Morianos]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Tsoutsa]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Kara]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<source><![CDATA[Am J Respir Crit Care Med]]></source>
<year>2013</year>
<volume>187</volume>
<numero>11</numero>
<issue>11</issue>
<page-range>1194-202</page-range></nlm-citation>
</ref>
<ref id="B41">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Role of CXCL13 in cigarette smoke-induced lymphoid follicle formation and chronic obstructive pulmonary disease]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bracke]]></surname>
<given-names><![CDATA[KR]]></given-names>
</name>
<name>
<surname><![CDATA[Verhamme]]></surname>
<given-names><![CDATA[FM]]></given-names>
</name>
<name>
<surname><![CDATA[Seys]]></surname>
<given-names><![CDATA[LJ]]></given-names>
</name>
</person-group>
<source><![CDATA[Am J Respir Crit Care Med]]></source>
<year>2013</year>
<volume>188</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>343-55</page-range></nlm-citation>
</ref>
<ref id="B42">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Lymphoid follicles in (very) severe COPD: Beneficial or harmful]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Brusselle]]></surname>
<given-names><![CDATA[GG]]></given-names>
</name>
<name>
<surname><![CDATA[Demoor]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Bracke]]></surname>
<given-names><![CDATA[KR]]></given-names>
</name>
<name>
<surname><![CDATA[Brandsma]]></surname>
<given-names><![CDATA[CA]]></given-names>
</name>
<name>
<surname><![CDATA[Timens]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
</person-group>
<source><![CDATA[Eur Respir J]]></source>
<year>2009</year>
<volume>34</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>219-30</page-range></nlm-citation>
</ref>
<ref id="B43">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Cigarette smoke-induced emphysema: a role for the B cell]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Van-Der-Strate]]></surname>
<given-names><![CDATA[BW]]></given-names>
</name>
<name>
<surname><![CDATA[Postma]]></surname>
<given-names><![CDATA[DS]]></given-names>
</name>
<name>
<surname><![CDATA[Brandsma]]></surname>
<given-names><![CDATA[CA]]></given-names>
</name>
<name>
<surname><![CDATA[Melgert]]></surname>
<given-names><![CDATA[BN]]></given-names>
</name>
<name>
<surname><![CDATA[Luinge]]></surname>
<given-names><![CDATA[MA]]></given-names>
</name>
<name>
<surname><![CDATA[Geerlings]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[Am J Respir Crit Care Med]]></source>
<year>2006</year>
<volume>173</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>751-8</page-range></nlm-citation>
</ref>
<ref id="B44">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Antielastin autoimmunity in tobacco smoking-induced emphysema]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[SH]]></given-names>
</name>
<name>
<surname><![CDATA[Goswami]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Grudo]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Song]]></surname>
<given-names><![CDATA[LZ]]></given-names>
</name>
<name>
<surname><![CDATA[Bandi]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Goodnight-White]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<source><![CDATA[Nat Med]]></source>
<year>2007</year>
<volume>13</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>567-9</page-range></nlm-citation>
</ref>
<ref id="B45">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Anti-tissue antibodies are related to lung function in chronic obstructive pulmonary disease]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Núñez]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Sauleda]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Antó]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
<name>
<surname><![CDATA[Julià]]></surname>
<given-names><![CDATA[MR]]></given-names>
</name>
<name>
<surname><![CDATA[Orozco]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Monsó]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<source><![CDATA[Am J Respir Crit Care Med]]></source>
<year>2011</year>
<volume>183</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>1025-31</page-range></nlm-citation>
</ref>
<ref id="B46">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Anti-proline-glycine-proline or antielastin autoantibodies are not evident in chronic inflammatory lung disease]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Greene]]></surname>
<given-names><![CDATA[CM]]></given-names>
</name>
<name>
<surname><![CDATA[Low]]></surname>
<given-names><![CDATA[TB]]></given-names>
</name>
<name>
<surname><![CDATA[O'Neill]]></surname>
<given-names><![CDATA[SJ]]></given-names>
</name>
<name>
<surname><![CDATA[McElvaney]]></surname>
<given-names><![CDATA[NG]]></given-names>
</name>
</person-group>
<source><![CDATA[Am J Respir Crit Care Med]]></source>
<year>2010</year>
<volume>181</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>31-5</page-range></nlm-citation>
</ref>
<ref id="B47">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Smoke exposure as a determinant of autoantibody titre in &#945;1-antitrypsin deficiency and COPD]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wood]]></surname>
<given-names><![CDATA[AM]]></given-names>
</name>
<name>
<surname><![CDATA[De-Pablo]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Buckley]]></surname>
<given-names><![CDATA[CD]]></given-names>
</name>
<name>
<surname><![CDATA[Ahmad]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Stockley]]></surname>
<given-names><![CDATA[RA]]></given-names>
</name>
</person-group>
<source><![CDATA[Eur Respir J]]></source>
<year>2011</year>
<volume>37</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>32-8</page-range></nlm-citation>
</ref>
<ref id="B48">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Antielastin B-cell and T-cell immunity in patients with chronic obstructive pulmonary disease]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rinaldi]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Lehouck]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Heulens]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Lavend'homme]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Carlier]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Saint-Remy]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
</person-group>
<source><![CDATA[Thorax]]></source>
<year>2012</year>
<volume>67</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>694-700</page-range></nlm-citation>
</ref>
<ref id="B49">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Autoantibodies in patients with chronic obstructive pulmonary disease]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Feghali-Bostwick]]></surname>
<given-names><![CDATA[CA]]></given-names>
</name>
<name>
<surname><![CDATA[Gadgil]]></surname>
<given-names><![CDATA[AS]]></given-names>
</name>
<name>
<surname><![CDATA[Otterbein]]></surname>
<given-names><![CDATA[LE]]></given-names>
</name>
<name>
<surname><![CDATA[Pilewski]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
<name>
<surname><![CDATA[Stoner]]></surname>
<given-names><![CDATA[MW]]></given-names>
</name>
<name>
<surname><![CDATA[Csizmadia]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<source><![CDATA[Am J Respir Crit Care Med]]></source>
<year>2008</year>
<volume>177</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>156-63</page-range></nlm-citation>
</ref>
<ref id="B50">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The Foxp3+ regulatory T cell: A jack of all trades, master of regulation]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tang]]></surname>
<given-names><![CDATA[Q]]></given-names>
</name>
<name>
<surname><![CDATA[Bluestone]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
</person-group>
<source><![CDATA[Nat Immunol]]></source>
<year>2008</year>
<volume>9</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>239-44</page-range></nlm-citation>
</ref>
<ref id="B51">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Four SNPs and systemic level of FOXP3 in smokers and patients with chronic obstructive pulmonary disease]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chu]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Zhong]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Lai]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Xie]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
</person-group>
<source><![CDATA[COPD]]></source>
<year>2016</year>
<volume>13</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>760-6</page-range></nlm-citation>
</ref>
<ref id="B52">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Interleukin-17 and type 17 helper T cells]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Miossec]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Korn]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Kuchroo]]></surname>
<given-names><![CDATA[VK]]></given-names>
</name>
</person-group>
<source><![CDATA[N Engl J Med]]></source>
<year>2009</year>
<volume>361</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>848-98</page-range></nlm-citation>
</ref>
<ref id="B53">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Imbalance of dendritic cell costimulation in COPD]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Stoll]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Ulrich]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Bratke]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Garbe]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Virchow]]></surname>
<given-names><![CDATA[JC]]></given-names>
</name>
<name>
<surname><![CDATA[Lommatzsch]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[Respir Res]]></source>
<year>2015</year>
<volume>16</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>19</page-range></nlm-citation>
</ref>
<ref id="B54">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Cigarette smoke affects dendritic cell maturation in the small airways of patients with chronic obstructive pulmonary disease]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Liao]]></surname>
<given-names><![CDATA[SX]]></given-names>
</name>
<name>
<surname><![CDATA[Ding]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Rao]]></surname>
<given-names><![CDATA[XM]]></given-names>
</name>
<name>
<surname><![CDATA[Sun]]></surname>
<given-names><![CDATA[PP]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[YJ]]></given-names>
</name>
<name>
<surname><![CDATA[Fu]]></surname>
<given-names><![CDATA[DD]]></given-names>
</name>
</person-group>
<source><![CDATA[Mol Med Rep]]></source>
<year>2015</year>
<volume>11</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>219-25</page-range></nlm-citation>
</ref>
<ref id="B55">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Dendritic cells in chronic obstructive pulmonary disease: new players in an old game]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tsoumakidou]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Demedts]]></surname>
<given-names><![CDATA[IK]]></given-names>
</name>
<name>
<surname><![CDATA[Brusselle]]></surname>
<given-names><![CDATA[GG]]></given-names>
</name>
<name>
<surname><![CDATA[Jeffery]]></surname>
<given-names><![CDATA[PK]]></given-names>
</name>
</person-group>
<source><![CDATA[Am J Respir Crit Care Med]]></source>
<year>2008</year>
<volume>177</volume>
<numero>11</numero>
<issue>11</issue>
<page-range>1180-6</page-range></nlm-citation>
</ref>
<ref id="B56">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Eosinophils in COPD: why should I care]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fernandes]]></surname>
<given-names><![CDATA[FL]]></given-names>
</name>
</person-group>
<source><![CDATA[J Bras Pneumol]]></source>
<year>2016</year>
<volume>42</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>237-8</page-range></nlm-citation>
</ref>
<ref id="B57">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Inflammatory triggers associated with exacerbations of COPD orchestrate plasticity of group 2 innate lymphoid cells in the lungs]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Silver]]></surname>
<given-names><![CDATA[JS]]></given-names>
</name>
<name>
<surname><![CDATA[Kearley]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Copenhaver]]></surname>
<given-names><![CDATA[AM]]></given-names>
</name>
<name>
<surname><![CDATA[Sanden]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Mori]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Yu]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<source><![CDATA[Nat Immunol]]></source>
<year>2016</year>
<volume>17</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>626-35</page-range></nlm-citation>
</ref>
<ref id="B58">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Microbiologic determinants of exacerbation in chronic obstructive pulmonary disease]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rossel]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Monsó]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Soler]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Torres]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Angrill]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Riise]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<source><![CDATA[Arch Intern Med]]></source>
<year>2005</year>
<volume>165</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>891-7</page-range></nlm-citation>
</ref>
<ref id="B59">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Experimental rhinovirus infection as a human model of chronic obstructive pulmonary disease exacerbation]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mallia]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Message]]></surname>
<given-names><![CDATA[SD]]></given-names>
</name>
<name>
<surname><![CDATA[Gielen]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Contoli]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Gray]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Kebadze]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<source><![CDATA[Am J Respir Crit Care Med]]></source>
<year>2011</year>
<volume>183</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>734-42</page-range></nlm-citation>
</ref>
<ref id="B60">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Innate immune recognition of viral infection]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kawai]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Akira]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<source><![CDATA[Nat Immunol]]></source>
<year>2006</year>
<volume>7</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>131-7</page-range></nlm-citation>
</ref>
<ref id="B61">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Toll-like receptors: critical proteins linking innate and acquired immunity]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Akira]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Takeda]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Kaisho]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<source><![CDATA[Nat Immunol]]></source>
<year>2001</year>
<volume>2</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>675-80</page-range></nlm-citation>
</ref>
<ref id="B62">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Innate immune recognition]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Janeway Jr]]></surname>
<given-names><![CDATA[CA]]></given-names>
</name>
<name>
<surname><![CDATA[Medzhitov]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<source><![CDATA[Annu Rev Immunol]]></source>
<year>2002</year>
<volume>20</volume>
<page-range>197-216</page-range></nlm-citation>
</ref>
<ref id="B63">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Pathogen recognition and innate immunity]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Akira]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Uematsu]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Takeuchi]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
</person-group>
<source><![CDATA[Cell]]></source>
<year>2006</year>
<volume>124</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>783-801</page-range></nlm-citation>
</ref>
<ref id="B64">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[TLR signaling pathways]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Takeda]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Akira]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<source><![CDATA[Semin Immunol]]></source>
<year>2004</year>
<volume>16</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>3-9</page-range></nlm-citation>
</ref>
<ref id="B65">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Mammalian Toll-like receptors]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Akira]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<source><![CDATA[Curr Opin Immunol]]></source>
<year>2003</year>
<volume>15</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>5-11</page-range></nlm-citation>
</ref>
<ref id="B66">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Tissue expression of human Toll-like receptors and differential regulation of Toll- like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zarember]]></surname>
<given-names><![CDATA[KA]]></given-names>
</name>
<name>
<surname><![CDATA[Godowski]]></surname>
<given-names><![CDATA[PJ]]></given-names>
</name>
</person-group>
<source><![CDATA[J Immunol]]></source>
<year>2002</year>
<volume>168</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>554-61</page-range></nlm-citation>
</ref>
<ref id="B67">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Current knowledge and future directions of TLR and NOD signaling in sepsis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Foley]]></surname>
<given-names><![CDATA[NM]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Redmond]]></surname>
<given-names><![CDATA[HP]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[JH]]></given-names>
</name>
</person-group>
<source><![CDATA[Mil Med Res]]></source>
<year>2015</year>
<volume>2</volume>
<page-range>1</page-range></nlm-citation>
</ref>
<ref id="B68">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Innate immunity underlies symbiotic relationships]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kisseleva]]></surname>
<given-names><![CDATA[EP]]></given-names>
</name>
</person-group>
<source><![CDATA[Biochemistry (Mosc)]]></source>
<year>2014</year>
<volume>79</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>1273-85</page-range></nlm-citation>
</ref>
<ref id="B69">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Lack of Toll IL-1R8 exacerbates Th17 cell responses in fungal infection]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bozza]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Zelante]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Moretti]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Bonifazi]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[DeLuca]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[D'Angelo]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<source><![CDATA[J Immunol]]></source>
<year>2008</year>
<volume>180</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>4022-31</page-range></nlm-citation>
</ref>
<ref id="B70">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Innate immunity but not NLRP3 inflammasome activation correlates with severity of stable COPD]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Di Stefano]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Caramori]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Barczyk]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Vicari]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Brun]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Zanini]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<source><![CDATA[Thorax]]></source>
<year>2014</year>
<volume>69</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>516-24</page-range></nlm-citation>
</ref>
<ref id="B71">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Acute cigarette smoke exposure impairs proteasome function in the lung]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Van-Rijt]]></surname>
<given-names><![CDATA[SH]]></given-names>
</name>
<name>
<surname><![CDATA[Keller]]></surname>
<given-names><![CDATA[IE]]></given-names>
</name>
<name>
<surname><![CDATA[John]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Kohse]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Yildirim]]></surname>
<given-names><![CDATA[AÖ]]></given-names>
</name>
<name>
<surname><![CDATA[Eickelberg]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
</person-group>
<source><![CDATA[Am J Physiol Lung Cell Mol Physiol]]></source>
<year>2012</year>
<volume>303</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>L814-23</page-range></nlm-citation>
</ref>
<ref id="B72">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Regulation of immunoproteasome function in the lung]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Keller]]></surname>
<given-names><![CDATA[IE]]></given-names>
</name>
<name>
<surname><![CDATA[Vosyka]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Takenaka]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Kloß]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Dahlmann]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Willems]]></surname>
<given-names><![CDATA[LI]]></given-names>
</name>
</person-group>
<source><![CDATA[Sci Rep]]></source>
<year>2015</year>
<volume>5</volume>
<edition>10230</edition>
</nlm-citation>
</ref>
<ref id="B73">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Proteostasis and the aging proteome in health and disease]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Morimoto]]></surname>
<given-names><![CDATA[RI]]></given-names>
</name>
<name>
<surname><![CDATA[Cuervo]]></surname>
<given-names><![CDATA[AM]]></given-names>
</name>
</person-group>
<source><![CDATA[J Gerontol A Biol Sci Med Sci]]></source>
<year>2014</year>
<volume>69</volume>
<numero>^sSuppl 1</numero>
<issue>^sSuppl 1</issue>
<supplement>Suppl 1</supplement>
<page-range>S33-8</page-range></nlm-citation>
</ref>
<ref id="B74">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Regulation of lung immunity and host defense by the intestinal microbiota]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Samuelson]]></surname>
<given-names><![CDATA[DR]]></given-names>
</name>
<name>
<surname><![CDATA[Welsh]]></surname>
<given-names><![CDATA[DA]]></given-names>
</name>
<name>
<surname><![CDATA[Shellito]]></surname>
<given-names><![CDATA[JE]]></given-names>
</name>
</person-group>
<source><![CDATA[Front Microbiol]]></source>
<year>2015</year>
<volume>6</volume>
<page-range>1085</page-range></nlm-citation>
</ref>
<ref id="B75">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Various mechanistic pathways representing the aging process are altered in COPD]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rutten]]></surname>
<given-names><![CDATA[EP]]></given-names>
</name>
<name>
<surname><![CDATA[Gopal]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Wouters]]></surname>
<given-names><![CDATA[EF]]></given-names>
</name>
<name>
<surname><![CDATA[Franssen]]></surname>
<given-names><![CDATA[FM]]></given-names>
</name>
<name>
<surname><![CDATA[Hageman]]></surname>
<given-names><![CDATA[GJ]]></given-names>
</name>
<name>
<surname><![CDATA[Vanfleteren]]></surname>
<given-names><![CDATA[LE]]></given-names>
</name>
</person-group>
<source><![CDATA[Chest]]></source>
<year>2016</year>
<volume>149</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>53-61</page-range></nlm-citation>
</ref>
<ref id="B76">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Chronic obstructive pulmonary disease and lung cancer: New molecular insights]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Adcock]]></surname>
<given-names><![CDATA[IM]]></given-names>
</name>
<name>
<surname><![CDATA[Caramori]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Barnes]]></surname>
<given-names><![CDATA[PJ]]></given-names>
</name>
</person-group>
<source><![CDATA[Respiration]]></source>
<year>2011</year>
<volume>81</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>265-84</page-range></nlm-citation>
</ref>
<ref id="B77">
<nlm-citation citation-type="">
<collab>Instituto Nacional del Cáncer</collab>
<source><![CDATA[Naturaleza del Cáncer]]></source>
<year>2017</year>
</nlm-citation>
</ref>
<ref id="B78">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Sirtuins in metabolism, DNA repair and cancer]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mei]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Yi]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Huang]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[He]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Tao]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
</person-group>
<source><![CDATA[J Exp Clin Cancer Res]]></source>
<year>2016</year>
<volume>35</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>182</page-range></nlm-citation>
</ref>
<ref id="B79">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Nakamaru]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Vuppusetty]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Wada]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Milne]]></surname>
<given-names><![CDATA[JC]]></given-names>
</name>
<name>
<surname><![CDATA[Ito]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Rossios]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<source><![CDATA[FASEB J]]></source>
<year>2009</year>
<volume>23</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>2810-9</page-range></nlm-citation>
</ref>
<ref id="B80">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Upregulation of SIRT6 predicts poor prognosis and promotes metastasis of non-small cell lung cancer via the ERK1/2/MMP9 pathway]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bai]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Lin]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Sun]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Liu]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Huang]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Cao]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<source><![CDATA[Oncotarget]]></source>
<year>2016</year>
<volume>7</volume>
<numero>26</numero>
<issue>26</issue>
<page-range>40377-86</page-range></nlm-citation>
</ref>
<ref id="B81">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Lung cancer and chronic obstructive pulmonary disease: From a clinical perspective]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Dai]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Yang]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Cox]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Jiang]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<source><![CDATA[Oncotarget]]></source>
<year>2017</year>
<volume>8</volume>
<numero>11</numero>
<issue>11</issue>
<page-range>18513-24</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
