<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2448-9190</journal-id>
<journal-title><![CDATA[Revista alergia México]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. alerg. Méx.]]></abbrev-journal-title>
<issn>2448-9190</issn>
<publisher>
<publisher-name><![CDATA[Colegio Mexicano de Inmunología Clínica y Alergia A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2448-91902017000200228</article-id>
<article-id pub-id-type="doi">10.29262/ram.v64i2.187</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Angioedema como única manifestación inicial de hipogammaglobulinemia]]></article-title>
<article-title xml:lang="en"><![CDATA[Angioedema as initial manifestation of hypogammaglobulinemia]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[López-Rocha]]></surname>
<given-names><![CDATA[Eunice]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[O&#8217;Farril-Romanillos]]></surname>
<given-names><![CDATA[Patricia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cerda-Reyes]]></surname>
<given-names><![CDATA[Saraid]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Medina-Torres]]></surname>
<given-names><![CDATA[Edgar A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Espinosa-Padilla]]></surname>
<given-names><![CDATA[Sara E.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Huerta-López]]></surname>
<given-names><![CDATA[José G.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Blancas-Galicia]]></surname>
<given-names><![CDATA[Lizbeth]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Mexicano del Seguro Social Centro Médico Nacional Siglo XXI Hospital de Especialidades]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Secretaría de Salud Instituto Nacional de Pediatría ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Secretaría de Salud Instituto Nacional de Pediatría ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2017</year>
</pub-date>
<volume>64</volume>
<numero>2</numero>
<fpage>228</fpage>
<lpage>234</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2448-91902017000200228&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2448-91902017000200228&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2448-91902017000200228&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: La inmunodeficiencia común variable se caracteriza por hipogammaglobulinemia e incapacidad para responder a las vacunas. Los pacientes en su mayoría manifiestan infecciones, sin embargo, menos de 5 % solo presenta patologías como autoinmunidad, inflamación granulomatosa, esplenomegalia o enfermedad linfoproliferativa, entre otras, sin infecciones. Se describe el caso de una mujer que debutó con afección cutánea localizada, angioedema facial, sin otros síntomas iniciales. Después del diagnóstico se documentó esplenomegalia y bronquiectasias. El angioedema y las bronquiectasias respondieron con la sustitución de la gammaglobulina intravenosa. En este artículo, además de la descripción del caso, se revisan las manifestaciones dermatológicas asociadas con inmunodeficiencia común variable.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: Common variable immunodeficiency is characterized by hypogammaglobulinemia and the inability to respond to vaccines. Patients mostly manifest infections, however only less than 5 % have pathological conditions as autoimmunity, granulomatous inflammation, and splenomegaly or lymphoproliferative disease among others, without showing infections. We report the case of a woman who debuted with localized cutaneous affection, facial angioedema, without other early symptoms. After diagnosis splenomegaly and bronchiectasis were documented. Angioedema and bronchiectasis responded with IVIG replacement. We also review the dermatological manifestations associated with CVID.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Inmunodeficiencia común variable]]></kwd>
<kwd lng="es"><![CDATA[Angioedema]]></kwd>
<kwd lng="es"><![CDATA[Enfermedades de la piel]]></kwd>
<kwd lng="es"><![CDATA[Inmunodeficiencias primarias en adultos]]></kwd>
<kwd lng="es"><![CDATA[Inmunoglobulina intravenosa]]></kwd>
<kwd lng="en"><![CDATA[Common variable immunodeficiency]]></kwd>
<kwd lng="en"><![CDATA[Angioedema]]></kwd>
<kwd lng="en"><![CDATA[Skin diseases]]></kwd>
<kwd lng="en"><![CDATA[Primary immunodeficiency diseases in adults]]></kwd>
<kwd lng="en"><![CDATA[Intravenous immunoglobulin]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Common variable immunodeficiency: Crossroads between infections, inflammation and autoimmunity]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Baldovino]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Montin]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Martino]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Sciascia]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Menegatti]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Roccatello]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<source><![CDATA[Autoimmun Rev]]></source>
<year>2013</year>
<volume>12</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>796-801</page-range></nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Perspectives on common variable immune deficiency]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Park]]></surname>
<given-names><![CDATA[JH]]></given-names>
</name>
<name>
<surname><![CDATA[Resnick]]></surname>
<given-names><![CDATA[ES]]></given-names>
</name>
<name>
<surname><![CDATA[Cunningham-Rundles]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<source><![CDATA[Ann N Y Acad Sci]]></source>
<year>2011</year>
<volume>1246</volume>
<page-range>41-9</page-range></nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[How I treat common variable immune deficiency]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cunningham-Rundles]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<source><![CDATA[Blood]]></source>
<year>2010</year>
<volume>116</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>7-15</page-range></nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Chronic urticaria and angioedema as the first presentations of common variable immunodeficiency]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Altschul]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Cunningham-Rundles]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<source><![CDATA[J Allergy Clin Immunol]]></source>
<year>2002</year>
<volume>110</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>664-5</page-range></nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Chapter 21: Urticaria and angioedema]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Carr]]></surname>
<given-names><![CDATA[TF]]></given-names>
</name>
<name>
<surname><![CDATA[Saltoun]]></surname>
<given-names><![CDATA[CA]]></given-names>
</name>
</person-group>
<source><![CDATA[Allergy Asthma Proc]]></source>
<year>2012</year>
<volume>33</volume>
<numero>^s1</numero>
<issue>^s1</issue>
<supplement>1</supplement>
<page-range>S70-2</page-range></nlm-citation>
</ref>
<ref id="B6">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Alopecia universalis in a patient with common variable immunodeficiency]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kilic]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Ersoy]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Sanal]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Türkbay]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Tezcan]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
</person-group>
<source><![CDATA[Pediatr Dermatol]]></source>
<year>1999</year>
<volume>16</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>305-307.</page-range></nlm-citation>
</ref>
<ref id="B7">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Common variable immunodeficiency presenting as chronic urticaria]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Smith]]></surname>
<given-names><![CDATA[AA]]></given-names>
</name>
<name>
<surname><![CDATA[Humphrey]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[McAuley]]></surname>
<given-names><![CDATA[JB]]></given-names>
</name>
<name>
<surname><![CDATA[Tharp]]></surname>
<given-names><![CDATA[MD]]></given-names>
</name>
</person-group>
<source><![CDATA[J Am Acad Dermatol.]]></source>
<year>2008</year>
<volume>59</volume>
<numero>2^s1</numero>
<issue>2^s1</issue>
<supplement>1</supplement>
<page-range>S40-1</page-range></nlm-citation>
</ref>
<ref id="B8">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[A case of common variable immunodeficiency presenting with furunculosis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sidwell]]></surname>
<given-names><![CDATA[RU]]></given-names>
</name>
<name>
<surname><![CDATA[Ibrahim]]></surname>
<given-names><![CDATA[MA]]></given-names>
</name>
<name>
<surname><![CDATA[Bunker]]></surname>
<given-names><![CDATA[CB]]></given-names>
</name>
</person-group>
<source><![CDATA[Br J Dermatol]]></source>
<year>2002</year>
<volume>147</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>364-7</page-range></nlm-citation>
</ref>
<ref id="B9">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Pityriasis lichenoides in a girl with the granulomatous form of common variable immunodeficiency]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pasic]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Pavlovic]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Vojvodic]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Abinun]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[Pediatr Dermatol]]></source>
<year>2002</year>
<volume>19</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>56-59.</page-range></nlm-citation>
</ref>
<ref id="B10">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Resolution of warts in association with subcutaneous immunoglobulin in immune deficiency]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lin]]></surname>
<given-names><![CDATA[JH]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[KY]]></given-names>
</name>
<name>
<surname><![CDATA[Kraft]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Roberts]]></surname>
<given-names><![CDATA[RL]]></given-names>
</name>
</person-group>
<source><![CDATA[Pediatr Dermatol]]></source>
<year>2009</year>
<volume>26</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>155-8</page-range></nlm-citation>
</ref>
<ref id="B11">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Cutaneous granulomas in common variable immunodeficiency: Case report and review of literature]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Aghamohammadi]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Abolhassani]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Rezaei]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Kalantari]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Tamizifar]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Cheragh]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<source><![CDATA[Acta Dermatovenerol Croat]]></source>
<year>2010</year>
<volume>18</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>107-13</page-range></nlm-citation>
</ref>
<ref id="B12">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Primary cutaneous actinomycosis caused by Actinomyces bovis in a patient with common variable immunodeficiency]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mansouri]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Farshi]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Khosravi]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Naraghi]]></surname>
<given-names><![CDATA[ZS]]></given-names>
</name>
</person-group>
<source><![CDATA[J Dermatol]]></source>
<year>2011</year>
<volume>38</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>911-5</page-range></nlm-citation>
</ref>
<ref id="B13">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Effect of IVIG on the hair regrowth in a common variable immune deficiency patient with alopecia universalis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Boonyaleepun]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Boonyaleepun]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Schlactus]]></surname>
<given-names><![CDATA[JL]]></given-names>
</name>
</person-group>
<source><![CDATA[Asian Pac J Allergy Immunol]]></source>
<year>1999</year>
<volume>17</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>59-62</page-range></nlm-citation>
</ref>
<ref id="B14">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Intravenous immunoglobulin therapy: How does IgG modulate the immune system?]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Schwab]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Nimmerjahn]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<source><![CDATA[Nature Rev Immunol]]></source>
<year>2013</year>
<volume>13</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>176-89</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
