<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2448-9190</journal-id>
<journal-title><![CDATA[Revista alergia México]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. alerg. Méx.]]></abbrev-journal-title>
<issn>2448-9190</issn>
<publisher>
<publisher-name><![CDATA[Colegio Mexicano de Inmunología Clínica y Alergia A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2448-91902017000200206</article-id>
<article-id pub-id-type="doi">10.29262/ram.v64i2.264</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Senescencia del sistema inmune y alteraciones relacionadas con el asma]]></article-title>
<article-title xml:lang="en"><![CDATA[Senescence of the immune system and alterations related with asthma]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vega-Robledo]]></surname>
<given-names><![CDATA[Gloria Bertha]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rico-Rosillo]]></surname>
<given-names><![CDATA[María Guadalupe]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional Autónoma de México Facultad de Medicina ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2017</year>
</pub-date>
<volume>64</volume>
<numero>2</numero>
<fpage>206</fpage>
<lpage>219</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2448-91902017000200206&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2448-91902017000200206&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2448-91902017000200206&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: La senescencia, proceso por el cual la célula entra en un estado de parálisis permanente del ciclo celular, implica cambios moleculares generalizados. Las células senescentes permanecen metabólicamente activas y la mayoría expresa el fenotipo secretor; mediante su secreción inciden en otras células y pueden inducir senescencia o cáncer. Por el contrario, en la llamada senescencia transitoria, las células secretoras pueden participar en la embriogénesis, la regeneración tisular y la respuesta inmune normal. Los cambios deletéreos asociados con la edad afectan a los integrantes del sistema inmune y la inmunosenescencia ocasiona pobre respuesta a vacunas y susceptibilidad a cáncer e infecciones. Estas últimas son causa frecuente de asma, sobre todo en ancianos, en quienes al parecer su incidencia va en aumento, lo que puede estar en relación con los cambios anatómicos, fisiológicos e inmunes ocasionados por la edad, la cronicidad del asma y los factores externos. La comorbilidad en los ancianos agrava el padecimiento y dificulta el diagnóstico, por lo que el conocimiento y manejo de estas entidades clínicas, deben ser del dominio de los médicos responsables de la atención primaria de los adultos mayores.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: Senescence is an irreversible process by which cells enter to a permanent cell cycle arrest with generalized molecular changes. Senescent cells remain metabolically active and most of them show a secretory phenotype; through its secretion may induce senescence or cancer in other cells. The secretory cells in the so-called transient senescence may participate in embryogenesis, tissue regeneration and immune response. The deleterious changes associated with age affect the immune system members and the immune senescence cause poor response to vaccines and susceptibility to cancer and infections. These latter are a frequent cause of asthma mostly in the elderly, the incidence is increasing in old people, and it may be related with those anatomical, physiological and immune changes caused by age, asthma chronicity and external agents. Comorbidity in the elderly worsens the ailment and hinders diagnosis, therefore, knowledge and handling of these clinical entities must be in control by the physicians responsible of the first level attention to old patients.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Senescencia]]></kwd>
<kwd lng="es"><![CDATA[Inmunosenescencia]]></kwd>
<kwd lng="es"><![CDATA[Inflamación]]></kwd>
<kwd lng="es"><![CDATA[Asma]]></kwd>
<kwd lng="en"><![CDATA[Senescence]]></kwd>
<kwd lng="en"><![CDATA[Immunosenescence]]></kwd>
<kwd lng="en"><![CDATA[Inflammation]]></kwd>
<kwd lng="en"><![CDATA[Asthma]]></kwd>
</kwd-group>
</article-meta>
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