<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2448-9190</journal-id>
<journal-title><![CDATA[Revista alergia México]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. alerg. Méx.]]></abbrev-journal-title>
<issn>2448-9190</issn>
<publisher>
<publisher-name><![CDATA[Colegio Mexicano de Inmunología Clínica y Alergia A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2448-91902017000200198</article-id>
<article-id pub-id-type="doi">10.29262/ram.v64i2.259</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Mediadores de la respuesta inflamatoria en asma y su relación con obesidad]]></article-title>
<article-title xml:lang="en"><![CDATA[Mediators of inflammatory response in asthma and its association with obesity]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Galicia-Negrete]]></surname>
<given-names><![CDATA[Gustavo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Falfán-Valencia]]></surname>
<given-names><![CDATA[Ramcés]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas Unidad de Investigación ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2017</year>
</pub-date>
<volume>64</volume>
<numero>2</numero>
<fpage>198</fpage>
<lpage>205</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2448-91902017000200198&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2448-91902017000200198&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2448-91902017000200198&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: El incremento en la prevalencia de asma y obesidad constituye un problema de salud pública en los ámbitos nacional y mundial. Se ha propuesto una sinergia entre estas patologías que genera broncoespasmos más severos, mayor tiempo de recuperación y uso de medicamentos por un lapso más prolongado en los pacientes asmáticos con obesidad. El descubrimiento de la leptina, relacionada directamente con la cantidad de grasa corporal total y la producción de citocinas proinflamatorias ha generado mayor interés en el tejido adiposo blanco. El objetivo de esta investigación fue describir la asociación entre obesidad, asma y los mecanismos fisiopatológicos involucrados. Se realizó una búsqueda bibliográfica en la literatura científica empleando el Centro Nacional de Información sobre Biotecnología (NCBI) de Estados Unidos como herramienta de búsqueda; las palabras claves utilizadas fueron asma, leptina, obesidad e inflamación. Numerosos estudios clínicos y experimentales exploran la participación de la obesidad como una entidad inflamatoria en el asma; algunos han evaluado el papel de polimorfismos genéticos &#8220;compartidos&#8221; por ambas patologías. Al parecer, existen mecanismos comunes a ambas patologías que pueden influir en la exacerbación de los síntomas del asma en pacientes con obesidad.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: There is an increase in the prevalence of asthma and obesity, constituting a public health problem at national and global levels. The association between the two pathologies has not been clearly determined; however, a certain synergy has been proposed, which leads to more severe bronchospasms, longer recovery time, and more prolonged use of medications in obese asthmatic patients. The discovery of leptin, an adipokine that is directly related to the amount of total body fat and the production of proinflammatory cytokines, has generated greater interest in white adipose tissue. Our objective was to describe the possible mechanisms involved and the association between obesity and asthma. A bibliographic search was conducted in the scientific literature using the National Biotechnology Information Center (NCBI) database of the USA as a search tool; keywords used were: asthma, leptin, obesity and inflammation. There are numerous clinical and experimental studies that explore the role of obesity as an inflammatory entity in asthma, some of which have evaluated the role of &#8220;shared&#8221; genetic polymorphisms in both pathologies. Apparently, the interaction between asthma and obesity is complex, there are mechanisms that link both pathologies, these can influence the improvement or exacerbation of symptoms.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Asma]]></kwd>
<kwd lng="es"><![CDATA[Inflamación]]></kwd>
<kwd lng="es"><![CDATA[Leptina]]></kwd>
<kwd lng="es"><![CDATA[Obesidad]]></kwd>
<kwd lng="en"><![CDATA[Asthma]]></kwd>
<kwd lng="en"><![CDATA[Inflammation]]></kwd>
<kwd lng="en"><![CDATA[Leptin]]></kwd>
<kwd lng="en"><![CDATA[Obesity]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="book">
<collab>Global Initiative for Asthma</collab>
<source><![CDATA[Global Strategy for Asthma Management and Prevention (update 2016)]]></source>
<year>2016</year>
<publisher-loc><![CDATA[USA ]]></publisher-loc>
<publisher-name><![CDATA[GINA]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The global burden of asthma]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Braman]]></surname>
<given-names><![CDATA[SS]]></given-names>
</name>
</person-group>
<source><![CDATA[Chest]]></source>
<year>2006</year>
<volume>130</volume>
<numero>1^sSuppl</numero>
<issue>1^sSuppl</issue>
<supplement>Suppl</supplement>
<page-range>4S-12S</page-range></nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Asthma: Epidemiology, etiology and risk factors]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Subbarao]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Mandhane]]></surname>
<given-names><![CDATA[PJ]]></given-names>
</name>
<name>
<surname><![CDATA[Sears]]></surname>
<given-names><![CDATA[MR]]></given-names>
</name>
</person-group>
<source><![CDATA[CMAJ]]></source>
<year>2009</year>
<volume>181</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>E181-90</page-range></nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Childhood obesity increases duration of therapy during severe asthma exacerbations]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Carroll]]></surname>
<given-names><![CDATA[CL]]></given-names>
</name>
<name>
<surname><![CDATA[Bhandari]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Zucker]]></surname>
<given-names><![CDATA[AR]]></given-names>
</name>
<name>
<surname><![CDATA[Schramm]]></surname>
<given-names><![CDATA[CM]]></given-names>
</name>
</person-group>
<source><![CDATA[Pediatr Crit Care Med]]></source>
<year>2006</year>
<volume>7</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>527-31</page-range></nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Increased incidence of asthmalike symptoms in girls who become overweight or obese during the school years]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Castro-Rodríguez]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Holberg]]></surname>
<given-names><![CDATA[CJ]]></given-names>
</name>
<name>
<surname><![CDATA[Morgan]]></surname>
<given-names><![CDATA[WJ]]></given-names>
</name>
<name>
<surname><![CDATA[Wright]]></surname>
<given-names><![CDATA[AL]]></given-names>
</name>
<name>
<surname><![CDATA[Martínez]]></surname>
<given-names><![CDATA[FD]]></given-names>
</name>
</person-group>
<source><![CDATA[Am J Respir Crit Care Med]]></source>
<year>2001</year>
<volume>163</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>1344-9</page-range></nlm-citation>
</ref>
<ref id="B6">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Food consumption and asthma in school children in Cuernavaca, Morelos, Mexico]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gutiérrez-Delgado]]></surname>
<given-names><![CDATA[RI]]></given-names>
</name>
<name>
<surname><![CDATA[Barraza-Villarreal]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Escamilla-Núñez]]></surname>
<given-names><![CDATA[MC]]></given-names>
</name>
<name>
<surname><![CDATA[Solano-González]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Moreno-Macías]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Romieu]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
</person-group>
<source><![CDATA[Salud Publica Mex]]></source>
<year>2009</year>
<volume>51</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>202-11</page-range></nlm-citation>
</ref>
<ref id="B7">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Exercise-induced bronchospasm or dyspnoea in obese children?]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Peroni]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Paiola]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Tenero]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[de-Luca]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<source><![CDATA[Allergol Immunopathol (Madr)]]></source>
<year>2009</year>
<volume>37</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>173-4</page-range></nlm-citation>
</ref>
<ref id="B8">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Exercise-induced bronchospasm in obese adolescents]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lopes]]></surname>
<given-names><![CDATA[WA]]></given-names>
</name>
<name>
<surname><![CDATA[Radominski]]></surname>
<given-names><![CDATA[RB]]></given-names>
</name>
<name>
<surname><![CDATA[Rosário Filho]]></surname>
<given-names><![CDATA[NA]]></given-names>
</name>
<name>
<surname><![CDATA[Leite]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
</person-group>
<source><![CDATA[Allergol Immunopathol (Madr)]]></source>
<year>2009</year>
<volume>37</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>175-9</page-range></nlm-citation>
</ref>
<ref id="B9">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Immediate and long term effects of weight reduction in obese people with asthma: Randomised controlled study]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Stenius-Aarniala]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Poussa]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Kvarnström]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Grönlund]]></surname>
<given-names><![CDATA[EL]]></given-names>
</name>
<name>
<surname><![CDATA[Ylikahri]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Mustajoki]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<source><![CDATA[BMJ]]></source>
<year>2000</year>
<volume>320</volume>
<numero>7238</numero>
<issue>7238</issue>
<page-range>827-32</page-range></nlm-citation>
</ref>
<ref id="B10">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Improvement in co-morbidities following weight loss from gastric bypass surgery]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Dhabuwala]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Cannan]]></surname>
<given-names><![CDATA[RJ]]></given-names>
</name>
<name>
<surname><![CDATA[Stubbs]]></surname>
<given-names><![CDATA[RS]]></given-names>
</name>
</person-group>
<source><![CDATA[Obes Surg]]></source>
<year>2000</year>
<volume>10</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>428-35</page-range></nlm-citation>
</ref>
<ref id="B11">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Aromatase inhibitors to augment height: continued caution and study required]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Geffner]]></surname>
<given-names><![CDATA[ME]]></given-names>
</name>
</person-group>
<source><![CDATA[J Clin Res Pediatr Endocrinol]]></source>
<year>2009</year>
<volume>1</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>256-61</page-range></nlm-citation>
</ref>
<ref id="B12">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Prospective study of body mass index, weight change, and risk of adult-onset asthma in women]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Camargo]]></surname>
<given-names><![CDATA[CA]]></given-names>
</name>
<name>
<surname><![CDATA[Weiss]]></surname>
<given-names><![CDATA[ST]]></given-names>
</name>
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Willett]]></surname>
<given-names><![CDATA[WC]]></given-names>
</name>
<name>
<surname><![CDATA[Speizer]]></surname>
<given-names><![CDATA[FE]]></given-names>
</name>
</person-group>
<source><![CDATA[Arch Intern Med]]></source>
<year>1999</year>
<volume>159</volume>
<numero>21</numero>
<issue>21</issue>
<page-range>2582-8</page-range></nlm-citation>
</ref>
<ref id="B13">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Significance of beta2-adrenergic receptor gene polymorphism in obesity and type 2 diabetes mellitus in Korean subjects]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[S-H]]></given-names>
</name>
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[D-J]]></given-names>
</name>
<name>
<surname><![CDATA[Seo]]></surname>
<given-names><![CDATA[IA]]></given-names>
</name>
<name>
<surname><![CDATA[Min]]></surname>
<given-names><![CDATA[YK]]></given-names>
</name>
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[MS]]></given-names>
</name>
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[KW]]></given-names>
</name>
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[MK]]></given-names>
</name>
</person-group>
<source><![CDATA[Metabolism]]></source>
<year>2002</year>
<volume>51</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>833-7</page-range></nlm-citation>
</ref>
<ref id="B14">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Interactive effects between polymorphisms in the beta-adrenergic receptors and longitudinal changes in obesity]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ellsworth]]></surname>
<given-names><![CDATA[DL]]></given-names>
</name>
<name>
<surname><![CDATA[Coady]]></surname>
<given-names><![CDATA[SA]]></given-names>
</name>
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Srinivasan]]></surname>
<given-names><![CDATA[SR]]></given-names>
</name>
<name>
<surname><![CDATA[Boerwinkle]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Berenson]]></surname>
<given-names><![CDATA[GS]]></given-names>
</name>
</person-group>
<source><![CDATA[Obes Res]]></source>
<year>2005</year>
<volume>13</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>519-26</page-range></nlm-citation>
</ref>
<ref id="B15">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Beta2-adrenoceptor polymorphisms predict response to beta2-agonists in children with acute asthma]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Martin]]></surname>
<given-names><![CDATA[AC]]></given-names>
</name>
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Rueter]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Khoo]]></surname>
<given-names><![CDATA[SK]]></given-names>
</name>
<name>
<surname><![CDATA[Bizzintino]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Hayden]]></surname>
<given-names><![CDATA[CM]]></given-names>
</name>
</person-group>
<source><![CDATA[J Asthma]]></source>
<year>2008</year>
<volume>45</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>383-8</page-range></nlm-citation>
</ref>
<ref id="B16">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Glucocorticoid receptor gene polymorphisms in Italian patients with eating disorders and obesity]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cellini]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Castellini]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Ricca]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Bagnoli]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Tedde]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Rotella]]></surname>
<given-names><![CDATA[CM]]></given-names>
</name>
</person-group>
<source><![CDATA[Psychiatr Genet]]></source>
<year>2010</year>
<volume>20</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>282-8</page-range></nlm-citation>
</ref>
<ref id="B17">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Tumor necrosis factor-alpha is a common genetic risk factor for asthma, juvenile rheumatoid arthritis, and systemic lupus erythematosus in a Mexican pediatric population]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jiménez-Morales]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Velázquez-Cruz]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Ramírez-Bello]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Bonilla-González]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Romero-Hidalgo]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Escamilla-Guerrero]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<source><![CDATA[Hum Immunol]]></source>
<year>2009</year>
<volume>70</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>251-6</page-range></nlm-citation>
</ref>
<ref id="B18">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Joint effect of obesity and TNFA variability on asthma: two international cohort studies]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Castro-Giner]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Kogevinas]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Imboden]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[de-Cid]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Jarvis]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Mächler]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[Eur Respir J]]></source>
<year>2009</year>
<volume>33</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>1003-9</page-range></nlm-citation>
</ref>
<ref id="B19">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Genetic variants in the UCP2-UCP3 gene cluster and risk of diabetes in the Women&#8217;s Health Initiative Observational Study]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hsu]]></surname>
<given-names><![CDATA[Y-H]]></given-names>
</name>
<name>
<surname><![CDATA[Niu]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Song]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Tinker]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Kuller]]></surname>
<given-names><![CDATA[LH]]></given-names>
</name>
<name>
<surname><![CDATA[Liu]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<source><![CDATA[Diabetes]]></source>
<year>2008</year>
<volume>57</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>1101-7</page-range></nlm-citation>
</ref>
<ref id="B20">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Linkage and association of childhood asthma with the chromosome 12 genes]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Shao]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Suzuki]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Kamada]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Kanno]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Tamari]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Hasegawa]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<source><![CDATA[J Hum Genet]]></source>
<year>2004</year>
<volume>49</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>115-22</page-range></nlm-citation>
</ref>
<ref id="B21">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Impaired lung function and serum leptin in men and women with normal body weight: A population based study]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sin]]></surname>
<given-names><![CDATA[DD]]></given-names>
</name>
<name>
<surname><![CDATA[Man]]></surname>
<given-names><![CDATA[SFP]]></given-names>
</name>
</person-group>
<source><![CDATA[Thorax]]></source>
<year>2003</year>
<volume>58</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>695-8</page-range></nlm-citation>
</ref>
<ref id="B22">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Leptin has a priming effect on eotaxininduced human eosinophil chemotaxis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kato]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Ueki]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Kamada]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Kihara]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Yamauchi]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Suzuki]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<source><![CDATA[Int Arch Allergy Immunol]]></source>
<year>2011</year>
<volume>155</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>335-44</page-range></nlm-citation>
</ref>
<ref id="B23">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[HsCRP levels: Measurement of airway inflammation in asthmatic children]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Soferman]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Glatstein]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Sivan]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Weisman]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
</person-group>
<source><![CDATA[Pediatr Int]]></source>
<year>2008</year>
<volume>50</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>12-6</page-range></nlm-citation>
</ref>
<ref id="B24">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Obesity, inflammation, and asthma severity in childhood: data from the National Health and Nutrition Examination Survey 2001-2004]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Michelson]]></surname>
<given-names><![CDATA[PH]]></given-names>
</name>
<name>
<surname><![CDATA[Williams]]></surname>
<given-names><![CDATA[LW]]></given-names>
</name>
<name>
<surname><![CDATA[Benjamin]]></surname>
<given-names><![CDATA[DK]]></given-names>
</name>
<name>
<surname><![CDATA[Barnato]]></surname>
<given-names><![CDATA[AE]]></given-names>
</name>
</person-group>
<source><![CDATA[Ann Allergy Asthma Immunol]]></source>
<year>2009</year>
<volume>103</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>381-5</page-range></nlm-citation>
</ref>
<ref id="B25">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[CC chemokine and CC chemokine receptor profiles in visceral and subcutaneous adipose tissue are altered in human obesity]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Huber]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Kiefer]]></surname>
<given-names><![CDATA[FW]]></given-names>
</name>
<name>
<surname><![CDATA[Zeyda]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Ludvik]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Silberhumer]]></surname>
<given-names><![CDATA[GR]]></given-names>
</name>
<name>
<surname><![CDATA[Prager]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<source><![CDATA[J Clin Endocrinol Metab]]></source>
<year>2008</year>
<volume>93</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>3215-21</page-range></nlm-citation>
</ref>
<ref id="B26">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Crystal structure of the obese protein leptin-E100]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Basinski]]></surname>
<given-names><![CDATA[MB]]></given-names>
</name>
<name>
<surname><![CDATA[Beals]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
<name>
<surname><![CDATA[Briggs]]></surname>
<given-names><![CDATA[SL]]></given-names>
</name>
<name>
<surname><![CDATA[Churgay]]></surname>
<given-names><![CDATA[LM]]></given-names>
</name>
<name>
<surname><![CDATA[Clawson]]></surname>
<given-names><![CDATA[DK]]></given-names>
</name>
</person-group>
<source><![CDATA[Nature]]></source>
<year>1997</year>
<volume>387</volume>
<numero>6629</numero>
<issue>6629</issue>
<page-range>206-9</page-range></nlm-citation>
</ref>
<ref id="B27">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Obesity hypertension: the regulatory role of leptin]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kshatriya]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Liu]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Salah]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Szombathy]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Freeman]]></surname>
<given-names><![CDATA[RH]]></given-names>
</name>
<name>
<surname><![CDATA[Reams]]></surname>
<given-names><![CDATA[GP]]></given-names>
</name>
</person-group>
<source><![CDATA[Int J Hypertens]]></source>
<year>2011</year>
<volume>2011</volume>
<page-range>270624</page-range></nlm-citation>
</ref>
<ref id="B28">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Identification of leptin receptors in lung and isolated fetal type II cells]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bergen]]></surname>
<given-names><![CDATA[HT]]></given-names>
</name>
<name>
<surname><![CDATA[Cherlet]]></surname>
<given-names><![CDATA[TC]]></given-names>
</name>
<name>
<surname><![CDATA[Manuel]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Scott]]></surname>
<given-names><![CDATA[JE]]></given-names>
</name>
</person-group>
<source><![CDATA[Am J Respir Cell Mol Biol]]></source>
<year>2002</year>
<volume>27</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>71-7</page-range></nlm-citation>
</ref>
<ref id="B29">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Structural organization and chromosomal assignment of the human obese gene]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Isse]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Ogawa]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Tamura]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Masuzaki]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Mori]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Okazaki]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<source><![CDATA[J Biol Chem]]></source>
<year>1995</year>
<volume>270</volume>
<numero>46</numero>
<issue>46</issue>
<page-range>27728-33</page-range></nlm-citation>
</ref>
<ref id="B30">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Las adipocinas: mediadores emergentes de la respuesta inmune y de la inflamación]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gómez]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Conde]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Gómez Reino]]></surname>
<given-names><![CDATA[JJ]]></given-names>
</name>
<name>
<surname><![CDATA[Lago]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Gualillo]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
</person-group>
<source><![CDATA[Reumatol Clin]]></source>
<year>2009</year>
<volume>5</volume>
<page-range>6-12</page-range></nlm-citation>
</ref>
<ref id="B31">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Leptin and asthma in overweight children at 12 years of age]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mai]]></surname>
<given-names><![CDATA[X-M]]></given-names>
</name>
<name>
<surname><![CDATA[Böttcher]]></surname>
<given-names><![CDATA[MF]]></given-names>
</name>
<name>
<surname><![CDATA[Leijon]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
</person-group>
<source><![CDATA[Pediatr Allergy Immunol]]></source>
<year>2004</year>
<volume>15</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>523-30</page-range></nlm-citation>
</ref>
<ref id="B32">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Does leptin play a role in obesity-asthma relationship?]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mai]]></surname>
<given-names><![CDATA[X-M]]></given-names>
</name>
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Krewski]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<source><![CDATA[Pediatr Allergy Immunol]]></source>
<year>2009</year>
<volume>20</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>207-12</page-range></nlm-citation>
</ref>
<ref id="B33">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Airway epithelium stimulates smooth muscle proliferation]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Malavia]]></surname>
<given-names><![CDATA[NK]]></given-names>
</name>
<name>
<surname><![CDATA[Raub]]></surname>
<given-names><![CDATA[CB]]></given-names>
</name>
<name>
<surname><![CDATA[Mahon]]></surname>
<given-names><![CDATA[SB]]></given-names>
</name>
<name>
<surname><![CDATA[Brenner]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Panettieri]]></surname>
<given-names><![CDATA[RA]]></given-names>
</name>
<name>
<surname><![CDATA[George]]></surname>
<given-names><![CDATA[SC]]></given-names>
</name>
</person-group>
<source><![CDATA[Am J Respir Cell Mol Biol]]></source>
<year>2009</year>
<volume>41</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>297-304</page-range></nlm-citation>
</ref>
<ref id="B34">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Asthma and obesity in children]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Story]]></surname>
<given-names><![CDATA[RE]]></given-names>
</name>
</person-group>
<source><![CDATA[Curr Opin Pediatr]]></source>
<year>2007</year>
<volume>19</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>680-4</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
