<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2448-8909</journal-id>
<journal-title><![CDATA[Medicina crítica (Colegio Mexicano de Medicina Crítica)]]></journal-title>
<abbrev-journal-title><![CDATA[Med. crít. (Col. Mex. Med. Crít.)]]></abbrev-journal-title>
<issn>2448-8909</issn>
<publisher>
<publisher-name><![CDATA[Colegio Mexicano de Medicina Crítica A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2448-89092023000400342</article-id>
<article-id pub-id-type="doi">10.35366/112169</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Índice PaO2/FiO2/PEEP como predictor de mortalidad en pacientes COVID-19]]></article-title>
<article-title xml:lang="en"><![CDATA[PaO2/FiO2/PEEP ratio as a predictor of mortality in COVID-19 patients]]></article-title>
<article-title xml:lang="pt"><![CDATA[PaO2 /FiO2 /PEEP index como preditor de mortalidade em pacientes com COVID-19]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ramos Estrada]]></surname>
<given-names><![CDATA[Marcos Sahib]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Muñoz Ramírez]]></surname>
<given-names><![CDATA[María del Rosario]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Mexicano del Seguro Social Unidad Médica de Alta Especialidad No. 25 ]]></institution>
<addr-line><![CDATA[Monterrey Nuevo León]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<volume>37</volume>
<numero>4</numero>
<fpage>342</fpage>
<lpage>347</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2448-89092023000400342&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2448-89092023000400342&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2448-89092023000400342&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen:  Introducción:  existe una necesidad urgente de identificar factores pronósticos, tanto clínicos como paraclínicos que permitan estratificar el riesgo del paciente y activamente controlar la COVID-19. En nuestro medio, no se han publicado estudios que evalúen el índice PaO2/FiO2/PEEP (P/F/PEEP) como predictor de mortalidad en pacientes COVID-19.  Objetivo:  determinar si el índice PaO2/FiO2/PEEP actúa como factor asociado con mortalidad en los pacientes COVID-19.  Material y métodos:  estudio retrospectivo, analítico y transversal en pacientes con diagnóstico de COVID-19 grave.  Resultados:  para el índice PaO2/FiO2 se identificaron valores más bajos entre los casos que fallecieron 143.23 ± 76.54 versus 162.79 ± 64.86 en los sobrevivientes; sin embargo, no se presentó significancia (p = 0.263). En el índice PaO2/FiO2/PEEP, las diferencias también disminuyeron entre los casos que fallecieron 140.27 ± 94.78 versus los sobrevivientes 191.25 ± 108.7 (p = 0.030).  Conclusiones:  el índice PaO2/FiO2/PEEP es un factor predictor de mortalidad en los pacientes COVID-19, se asocia significativamente con una AUC superior al índice PaO2/FiO2 para predecir la mortalidad en un punto de corte de &#8804; 80 como factor de mortalidad con un buena especificidad y alta sensibilidad.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract:  Introduction:  there is an urgent need to identify prognostic factors, both clinical and paraclinical, that allow patient risk stratification and active control of COVID-19. In our setting, there have been no published studies evaluating the PaO2 /FiO2 /PEEP (P/F/PEEP) index as a predictor of mortality in COVID-19 patients.  Objective:  to determine if the PaO2/FiO2/PEEP index acts as a factor associated with mortality in COVID-19 patients.  Material and methods:  retrospective, analytical and cross-sectional study in patients diagnosed with severe COVID-19.  Results:  lower values were identified for the PaO2/FiO2 index among the cases that died: 143.23 ± 76.54 vs 162.79 ± 64.86 in the survivors, however, there was no significance (p = 0.263). In the PaO2/FiO2/PEEP index, the differences also decreased between the cases that died 140.27 ± 94.78 vs the survivors 191.25 ± 108.7 (p = 0.030).  Conclusions:  the PaO2/FiO2/PEEP index is a predictor of mortality in COVID-19 patients, it is significantly associated with an AUC higher than the PaO2/FiO2 index to predict mortality at a cut-off point of &#8804; 80 as a mortality factor with a good specificity and high sensitivity.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo:  Introdução:  há uma necessidade urgente de identificar fatores prognósticos, tanto clínicos quanto paraclínicos, que permitam a estratificação de risco do paciente e o controle ativo do COVID-19. Em nosso meio, não foram publicados estudos que avaliem a PaO2/FiO2/PEEP (P/F/PEEP) como preditor de mortalidade em pacientes com COVID-19.  Objetivo:  determinar se o índice PaO2/FiO2/PEEP atua como fator associado à mortalidade em pacientes com COVID-19.  Material e métodos:  estudo retrospectivo, analítico e transversal em pacientes diagnosticados com COVID-19 grave.  Resultados:  foram identificados valores menores para o índice PaO2/FiO2 entre os casos que foram a óbito: 143.23 ± 76.54 vs 162.79 ± 64.86 nos sobreviventes, porém, não houve significância (p = 0.263). No índice PaO2/FiO2/PEEP, as diferenças também diminuíram entre os casos que faleceram 140.27 ± 94.78 vs os sobreviventes 191.25 ± 108.7 (p = 0.030).  Conclusões:  o índice PaO2/FiO2/PEEP é um preditor de mortalidade em pacientes com COVID-19, está significativamente associado a uma AUC maior que o índice PaO2/FiO2 para prever mortalidade em um ponto de corte &#8804; 80 como fator de mortalidade com uma boa especificidade e alta sensibilidade.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[COVID-19]]></kwd>
<kwd lng="es"><![CDATA[síndrome de dificultad respiratoria aguda]]></kwd>
<kwd lng="es"><![CDATA[índice PaO2/FiO2]]></kwd>
<kwd lng="es"><![CDATA[índice PaO2/FiO2/PEEP]]></kwd>
<kwd lng="es"><![CDATA[mortalidad]]></kwd>
<kwd lng="en"><![CDATA[COVID-19]]></kwd>
<kwd lng="en"><![CDATA[acute respiratory distress syndrome]]></kwd>
<kwd lng="en"><![CDATA[PaO2/FiO2 ratio]]></kwd>
<kwd lng="en"><![CDATA[PaO2/FiO2/PEEP ratio]]></kwd>
<kwd lng="en"><![CDATA[mortality]]></kwd>
<kwd lng="pt"><![CDATA[COVID-19]]></kwd>
<kwd lng="pt"><![CDATA[síndrome do desconforto respiratório agudo]]></kwd>
<kwd lng="pt"><![CDATA[relação PaO2/FiO2]]></kwd>
<kwd lng="pt"><![CDATA[relação PaO2/FiO2/PEEP]]></kwd>
<kwd lng="pt"><![CDATA[mortalidade]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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