<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2448-8909</journal-id>
<journal-title><![CDATA[Medicina crítica (Colegio Mexicano de Medicina Crítica)]]></journal-title>
<abbrev-journal-title><![CDATA[Med. crít. (Col. Mex. Med. Crít.)]]></abbrev-journal-title>
<issn>2448-8909</issn>
<publisher>
<publisher-name><![CDATA[Colegio Mexicano de Medicina Crítica A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2448-89092023000200134</article-id>
<article-id pub-id-type="doi">10.35366/110449</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[La vitamina C, implicaciones terapéuticas en el paciente con quemaduras graves]]></article-title>
<article-title xml:lang="en"><![CDATA[Vitamin C, therapeutic implications in the patient with serious burns]]></article-title>
<article-title xml:lang="pt"><![CDATA[Vitamina C, implicações terapêuticas no paciente com queimaduras graves]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Garnica Escamilla]]></surname>
<given-names><![CDATA[Marco Antonio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hernández Peña]]></surname>
<given-names><![CDATA[Raqueli]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sánchez Zúñiga]]></surname>
<given-names><![CDATA[Martín de Jesús]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Tamez Coyotzin]]></surname>
<given-names><![CDATA[Elvira Alejandra]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vázquez Guerra]]></surname>
<given-names><![CDATA[Luis Iván]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Garza Carrión]]></surname>
<given-names><![CDATA[Jorge Alberto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ramírez Vallarde]]></surname>
<given-names><![CDATA[Nancy Esmeralda]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Jimeno Papova]]></surname>
<given-names><![CDATA[Rebeca Galia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Nacional de Rehabilitación. «Luis Guillermo Ibarra Ibarra»  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto Mexicano del Seguro Social Hospital General Regional 2 «El Marques» ]]></institution>
<addr-line><![CDATA[Querétaro ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado Hospital Regional «Gral. Ignacio Zaragoza» ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Instituto Mexicano del Seguro Social Hospital General Regional 1 ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Instituto Nacional de Pediatría  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<volume>37</volume>
<numero>2</numero>
<fpage>134</fpage>
<lpage>140</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2448-89092023000200134&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2448-89092023000200134&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2448-89092023000200134&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: La atención a pacientes con quemaduras extensas es compleja, la quemadura condiciona efectos en el sitio de la lesión y a nivel sistémico. A nivel de la microcirculación se presenta respuesta de mediadores químicos inflamatorios y excesiva producción de especies reactivas de oxígeno y nitrógeno, además condiciona disminución de la capacidad antioxidante de vitamina C, por lo que se altera el balance fisiológico de óxido-reducción, dando paso al estado de estrés oxidativo, esto trae como consecuencia un incremento en la inflamación, disfunción endotelial e incremento de la permeabilidad capilar. Uno de los objetivos de la reanimación del paciente quemado es restaurar el volumen intravascular generado por el estado de choque, en el cual se implementan estrategias como el uso de cristaloides, coloides, plasma, terapias dialíticas, uso limitado de opioides y la administración de vitamina C. El objetivo de este trabajo es dar a conocer a la comunidad médica las características físicas y químicas, los mecanismos moleculares de la vitamina C en los que se encuentra implicada en condiciones de quemaduras graves, con la finalidad de la implementación durante la fase de reanimación del quemado.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: The care of patients with extensive burns is complex, the burn conditions effects at the site of the injury and at the systemic level. At the microcirculation level, there is a response of inflammatory chemical mediators and excessive production of reactive oxygen and nitrogen species, which also causes a decrease in the antioxidant capacity of vitamin C, which is why the physiological balance of oxide-reduction is altered, giving way to the state of oxidative stress, this results in an increase in inflammation, endothelial dysfunction and an increase in capillary permeability. One of the objectives of the resuscitation of the burned patient is to restore the intravascular volume generated by the state of shock, in which strategies such as the use of crystalloids, colloids, plasma, dialysis therapies, limited use of opioids and the administration of vitamins are implemented C. The objective of this work is to make known to the medical community, the physical and chemical characteristics, the molecular mechanisms of vitamin C in which it is involved in severe burn conditions, with the purpose of implementation during the resuscitation phase of burn.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo: O atendimento a pacientes com queimaduras extensas é complexo, a queimadura condiciona efeitos no local da lesão e em nível sistêmico. Ao nível da microcirculação, há uma resposta de mediadores químicos inflamatórios e produção excessiva de espécies reativas de oxigénio e nitrogênio, condiciona também uma diminuição da capacidade antioxidante da vitamina C, que altera o equilíbrio fisiológico de oxidação-redução, dando lugar a o estado de estresse oxidativo, isso resulta em aumento da inflamação, disfunção endotelial e aumento da permeabilidade capilar. Um dos objetivos da ressuscitação do paciente queimado é restaurar o volume intravascular gerado pelo estado de choque, no qual se implementam estratégias como o uso de cristalóides, colóides, plasma, terapias dialíticas, uso limitado de opióides e administração de vitamina C. O objetivo deste trabalho é dar a conhecer à comunidade médica as características físicas e químicas, os mecanismos moleculares da vitamina C em que está envolvida em condições de queimaduras graves, com vista à sua aplicação durante a fase de reanimação do paciente queimado.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[quemaduras]]></kwd>
<kwd lng="es"><![CDATA[vitamina C]]></kwd>
<kwd lng="es"><![CDATA[estrés oxidativo]]></kwd>
<kwd lng="es"><![CDATA[permeabilidad endotelial]]></kwd>
<kwd lng="en"><![CDATA[burns]]></kwd>
<kwd lng="en"><![CDATA[vitamin C]]></kwd>
<kwd lng="en"><![CDATA[oxidative stress]]></kwd>
<kwd lng="en"><![CDATA[endothelial permeability]]></kwd>
<kwd lng="pt"><![CDATA[queimaduras]]></kwd>
<kwd lng="pt"><![CDATA[vitamina C]]></kwd>
<kwd lng="pt"><![CDATA[estresse oxidativo]]></kwd>
<kwd lng="pt"><![CDATA[permeabilidade endotelial]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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