<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2448-8909</journal-id>
<journal-title><![CDATA[Medicina crítica (Colegio Mexicano de Medicina Crítica)]]></journal-title>
<abbrev-journal-title><![CDATA[Med. crít. (Col. Mex. Med. Crít.)]]></abbrev-journal-title>
<issn>2448-8909</issn>
<publisher>
<publisher-name><![CDATA[Colegio Mexicano de Medicina Crítica A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2448-89092022000700463</article-id>
<article-id pub-id-type="doi">10.35366/108714</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Comparación de la eficacia de la transfusión de paquetes globulares de &#8804; 15 vs &#8805; 16 a 40 días de extracción sobre los efectos hemodinámicos y gasométricos de pacientes con traumatismo craneoencefálico severo en la Unidad de Cuidados Intensivos]]></article-title>
<article-title xml:lang="en"><![CDATA[Comparison of the efficacy of the transfusion of globular packages of &#8804; 15 vs &#8805; 16 to 40 days of extraction on the hemodynamic and gasometric effects of patients with severe traumatic brain in the Intensive Care Unit]]></article-title>
<article-title xml:lang="pt"><![CDATA[Comparação da eficácia da transfusão de hemácias de &#8804; 15 vs &#8805; 16 a 40 dias de extração sobre os efeitos hemodinâmicos e gasométricos de pacientes com traumatismo cranioencefálico grave na Unidade de Terapia Intensiva]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Quintero Martínez]]></surname>
<given-names><![CDATA[Edgar Omar]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martínez Romero]]></surname>
<given-names><![CDATA[Karen Saraí]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gutiérrez Martínez]]></surname>
<given-names><![CDATA[Carlos Alberto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Mexicano del Seguro Social Centro Médico Nacional de Occidente Hospital de Especialidades]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2022</year>
</pub-date>
<volume>36</volume>
<numero>7</numero>
<fpage>463</fpage>
<lpage>471</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2448-89092022000700463&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2448-89092022000700463&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2448-89092022000700463&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[resumen está disponible en el texto completo]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract:  Introduction:  since the beginning of blood banks, refinements in laboratory processes have allowed longer red blood cell storage times. While advantageous to the logistics of stock management, the clinical impact of RBC storage duration prior to transfusion remains uncertain and a topic of growing interest. Although the structural, biochemical, and impermeable changes that red blood cells undergo during storage are well described, the evidence that this storage injury translates into adverse clinical outcomes for patients receiving blood with longer storage times remains controversial.  Objective:  to compare the efficacy of the transfusion of globular packages of &#8804; 15 days of extraction vs. globular packages &#8805; 16-40 days of extraction in the hemodynamic and gasometric repercussion of patients with severe traumatic brain injury (TBI), hospitalized in the Intensive Care Unit of HE CMNO.  Material and methods:  a controlled, single-center, randomized, single-blind, prospective and comparative clinical trial was conducted, where patients between 18 and 80 years of age with severe postoperative cranioencephalic trauma who required blood transfusions were invited to participate. Participants were included in two random groups, group F and group E. Group F was administered packed cells &#8804; 15 days of extraction. Group E will be administered globular packages &#8805; 16-40 days of extraction. During the study, various hemodynamic and biochemical variables were measured before, during, and after blood transfusion, and a comparison of the results obtained between groups F and E was subsequently made.  Results:  in the present study, a total of 26 patients with severe TBI were included and who were transfused with red blood cell packs, of the total number of patients, 13 were transfused with a «standard» red blood cell pack and another 13 patients with a «fresh» red blood cell pack. The average days of transfusion after extraction were 18 and 14 days for the «standard» and «fresh» packs, respectively (p &#8804; 0.001). Twenty-one infectious events were reported, 11 in the group of patients who were transfused with the standard pack and 10 in the fresh pack group. Mortality at 28 days was estimated in 31% of the patients transfused with the standard pack and in 23% of the patients with the fresh pack (RR, for 28-day mortality of 0.90 [95% CI 0.56-144]). The median duration time in the intensive care unit was 8 days for both groups (0.32 SD), and of the days associated with the ventilator, 15 days were observed for the group of patients with the standard package and 7 for the group with fresh package (0.60 SD), without discovering statistically significant differences in these variables. However, in this analysis statistically significant differences were found for the gasometric parameters of central venous oxygen saturation, cardiac output (Fick) and lactate before and after transfusion in favor of the group of patients transfused with fresh pack (p &#8804; 0.05).  Conclusion:  the results of this study infer that there is no association between the storage time of transfused red blood cells and the presence of adverse clinical outcomes with longer storage times. In both groups, transfusions were equally safe and effective. The researchers refer to the sample size as a limitation for this study.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo:  Introdução:  desde o surgimento dos bancos de sangue, o refinamento dos processos laboratoriais permitiu tempos de estocagem cada vez mais longos para as hemácias. Embora vantajoso para a logística do gerenciamento de estoque, o impacto clínico da duração do armazenamento de glóbulos vermelhos antes da transfusão permanece incerto e um tópico de interesse crescente. Embora as alterações estruturais, bioquímicas e imunológicas pelas quais as hemácias sofrem durante o armazenamento sejam bem descritas, as evidências de que essa lesão de armazenamento resulta em resultados clínicos adversos para pacientes que recebem sangue armazenado por mais tempo permanecem controversas.  Objetivo:  comparar a eficácia da transfusão de concentrado de hemácias &#8804; 15 dias de extração vs concentrado de hemácias &#8805; 16-40 dias de extração nas repercussão hemodinâmica e gasométrica dos pacientes com traumatismo cranioencefálico (TCE) grave, internados em Unidade de Terapia Intensiva do HE CMN Occidente.  Material e métodos:  realizou-se um ensaio clínico, controlado, unicêntrico, randomizado, simples-cego, prospectivo e comparativo, onde foram convidados a participar pacientes com idade entre 18 e 80 anos com traumatismo cranioencefálico grave submetidos a hemicraniectomia descompressiva com necessidade de transfusão sanguínea. Os participantes foram incluídos aleatoriamente em 2 grupos, grupo F e grupo E. Grupo F recebeu concentrado de hemácias &#8804; 15 dias após a extração. O grupo E receberá concentrado de hemácias &#8805; 16-40 dias após a extração. Durante o estudo, várias variáveis hemodinâmicas e bioquímicas foram medidas antes, durante e após a transfusão de sangue, e posteriormente foi feita uma comparação dos resultados obtidos entre os grupos F e E.  Resultados:  no presente estudo incluíram-se um total de 26 pacientes com TCE grave e que foram transfundidos com concentrado de hemácias, do total de pacientes 13 foram transfundidos com um concentrado de hemácias «padrão» e outros 13 pacientes com um concentrado de hemácias «fresco». A média de dias de transfusão após a extração foi de 18 e 14 dias para as pacotes «padrão» e «fresco», respectivamente (p &#8804; 0.001). Relatou-se 21 eventos infecciosos, 11 no grupo de pacientes que receberam transfusão com concentrado padrão e 10 no grupo com concentrado fresco. A mortalidade em 28 dias foi estimada em 31% dos pacientes transfundidos com concentrado padrão e em 23% dos pacientes com concentrado fresco (RR, para mortalidade em 28 dias de 0.90 (IC 95% 0.56-144). A duração mediana na unidade de terapia intensiva foi de 8 dias para ambos os grupos (0.32 DP), sendo que 2 dias associados ao ventilador, foram observados 15 dias para o grupo de pacientes com concentrado padrão e 7 para o grupo de concentrado fresco (0.60 DE), sem descobrir diferenças estatisticamente significativas nas referidas variáveis.No entanto, nesta análise foram encontradas diferenças estatisticamente significativas para os parâmetros gasométricos de saturação venosa central de oxigênio, débito cardíaco (Fick) e lactato antes e após a transfusão em favor do grupo de pacientes transfundidos com concentrado fresco (p &#8804; 0.05).  Conclusão:  os resultados deste estudo inferem que não há associação entre o tempo de estocagem das hemácias transfundidas e a presença de desfechos clínicos adversos com tempos de estocagem mais longos. Em ambos os grupos, as transfusões foram igualmente seguras e eficazes. Os pesquisadores referem-se ao tamanho da amostra como limitante para este estudo.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[transfusión sanguínea]]></kwd>
<kwd lng="es"><![CDATA[glóbulos rojos]]></kwd>
<kwd lng="es"><![CDATA[anemia]]></kwd>
<kwd lng="es"><![CDATA[traumatismo craneoencefálico]]></kwd>
<kwd lng="en"><![CDATA[blood transfusion]]></kwd>
<kwd lng="en"><![CDATA[red blood cells]]></kwd>
<kwd lng="en"><![CDATA[anemia]]></kwd>
<kwd lng="en"><![CDATA[cranioencephalic trauma]]></kwd>
<kwd lng="pt"><![CDATA[transfusão de sangue]]></kwd>
<kwd lng="pt"><![CDATA[hemácias]]></kwd>
<kwd lng="pt"><![CDATA[anemia]]></kwd>
<kwd lng="pt"><![CDATA[traumatismo cranioencefálico]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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</back>
</article>
