<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2448-8909</journal-id>
<journal-title><![CDATA[Medicina crítica (Colegio Mexicano de Medicina Crítica)]]></journal-title>
<abbrev-journal-title><![CDATA[Med. crít. (Col. Mex. Med. Crít.)]]></abbrev-journal-title>
<issn>2448-8909</issn>
<publisher>
<publisher-name><![CDATA[Colegio Mexicano de Medicina Crítica A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2448-89092022000100014</article-id>
<article-id pub-id-type="doi">10.35366/104471</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Relación neutrófilos, linfocitos y plaquetas como predictor de lesión renal aguda en sepsis por COVID-19 en la Unidad de Cuidados Intensivos]]></article-title>
<article-title xml:lang="en"><![CDATA[Neutrophiles, lymphocytes and platelets ratio as a predictor of acute kidney injury in sepsis by COVID-19 in the Intensive Care Unit]]></article-title>
<article-title xml:lang="pt"><![CDATA[Relação de neutrófilos, linfócitos e plaquetas como preditor de lesão renal aguda na sepse por COVID-19 na Unidade de Terapia Intensiva]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Contreras Chávez]]></surname>
<given-names><![CDATA[Marisol]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bravo Santibáñez]]></surname>
<given-names><![CDATA[Edgar]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hernández González]]></surname>
<given-names><![CDATA[Martha Alicia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[López Briones]]></surname>
<given-names><![CDATA[Sergio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González Carrillo]]></surname>
<given-names><![CDATA[Pedro Luis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Mexicano del Seguro Social Unidad Médica de Alta Especialidad ]]></institution>
<addr-line><![CDATA[León Guanajuato]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Guanajuato  ]]></institution>
<addr-line><![CDATA[León Guanajuato]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>02</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>02</month>
<year>2022</year>
</pub-date>
<volume>36</volume>
<numero>1</numero>
<fpage>14</fpage>
<lpage>21</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2448-89092022000100014&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2448-89092022000100014&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2448-89092022000100014&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen:  Introducción:  La lesión renal aguda se encuentra en 40% de los pacientes que presentan sepsis (S-LRA), ya que la inflamación es una de las causas fisiopatológicas de la lesión renal aguda. Durante la pandemia, la principal causa de sepsis en la unidad de cuidados intensivos (UCI) fue secundaria a enfermedad por coronavirus 2019 (COVID-19), en ésta se ha reportado incidencia de lesión renal de 36 a 75%. La fisiopatología de esta complicación aún no se conoce, pero se han demostrado mecanismos similares a la lesión renal séptica típica. La relación neutrófilos, linfocitos y plaquetas (RNLP) previamente se ha asociado con la presencia de lesión renal aguda en otros ámbitos (cirugía cardiaca y cirugía abdominal mayor), y en pacientes con sepsis secundaria a COVID-19 puede ser un marcador que identifique a los pacientes con riesgo de presentar esta complicación.  Objetivo:  Determinar si la relación neutrófilos, linfocitos y plaquetas es un predictor de lesión renal aguda en sepsis secundaria a COVID-19 en la UCI adultos.  Material y métodos:  Estudio de cohorte prospectiva, unicéntrico. En pacientes mayores de 18 años que ingresen a la UCI con diagnóstico de sepsis por COVID-19 se realizará el cálculo de la RNLP desde el día uno hasta el día siete. Se dividen en dos grupos: RNLP mayor de tres puntos y RNLP igual o menor de tres puntos, observando presencia o no de lesión renal aguda durante su estancia, y posterior al desenlace. Para el objetivo principal se hace prueba &#967;2, y se realiza prueba de regresión logística multivariable para valorar la asociación de las diferentes variables con el desenlace (OR IC95%).  Resultados:  Se estudió una población de 119 pacientes, se obtuvo una incidencia de lesión renal aguda inducida por sepsis (S-LRA) de 53.8% (IC95% 44-62%) en pacientes con sepsis secundaria a COVID-19, siendo la mayoría KDIGO I (53.2%). El grupo de RNLP mayor de tres tuvo una incidencia de 68.4% de S-LRA en comparación con el grupo de RNLP igual o menor de tres con 28% (p = 0.001, OR 4.255 IC95% 1.782-10.16), los pacientes con RNLP mayor de tres tuvieron estancia más prolongada en la UCI (12 versus 10 días, p = 0.018), y más tiempo de ventilación mecánica (11 versus ocho días, p = 0.003).  Conclusión:  El incremento de la relación neutrófilos, linfocitos y plaquetas es un factor de riesgo y puede ser pronóstico para la presencia de lesión renal aguda en sepsis por COVID-19 en la UCI.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract:  Introduction:  Acute kidney injury is found in 40% of patients with sepsis (S-AKI), since inflammation is one of the pathophysiological causes of acute kidney injury. During the pandemic, the main cause of sepsis in the ICU was secondary to COVID-19, in which an incidence of kidney injury of 36 to 75% has been reported. The pathophysiology of this complication is not yet known, but mechanisms similar to typical septic kidney injury have been demonstrated. The neutrophil, lymphocyte and platelet ratio (RNLP) has previously been associated with the presence of acute kidney injury in other settings (cardiac surgery and major abdominal surgery) and in patients with sepsis secondary to COVID-19 it may be a marker that identifies the patients at risk of presenting this complication.  Objective:  To determine if the ratio of neutrophils, lymphocytes and platelets is a predictor of acute kidney injury in sepsis secondary to COVID-19 in the adult ICU.  Material and methods:  Prospective, single-center cohort study. In patients over 18 years of age who are admitted to the ICU with a diagnosis of sepsis due to COVID-19, the RNLP will be calculated from day 1 to day 7, it is divided into 2 groups: RNLP greater than 3 and RNLP equal or less than 3, observing the presence or not of acute kidney injury during their stay, and after the outcome, for the main objective a &#967;2 test is performed, and a multivariate logistic regression test is performed to assess the Association of the different variables with the outcome (OR with 95% CI).  Results:  A population of 119 patients was studied, there was an incidence of S-AKI of 53.8% (95% CI 44-62%) in patients with sepsis secondary to COIVD-19, the majority being KDIGO I (53.2%). In the RNLP group greater than 3 I had a 68.4% incidence of S-AKI compared to the RNLP group less than or equal to 3 with 28% (p = 0.001, OR 4.255 95% CI 1.72-10.16), the patients with RNLP greater than 3 had a longer stay in the ICU (12 vs 10 days, p = 0.018), and a longer time of mechanical ventilation (11 vs 8 days, p = 0.003).  Conclusion:  The increase in the neutrophil, lymphocyte and platelet ratio is a risk factor and can be a prognostic for the presence of acute kidney injury in sepsis due to COVID-19 in the ICU.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo:  Introdução:  A lesão renal aguda é encontrada em 40% dos pacientes com sepse (S-LRA), uma vez que a inflamação é uma das causas fisiopatológicas da lesão renal aguda. Durante a pandemia, a principal causa de sepse na UTI foi secundária à COVID-19, na qual a incidência de lesão renal foi relatada de 36 a 75%. A fisiopatologia dessa complicação ainda não é conhecida, mas mecanismos semelhantes à lesão renal séptica típica foram demonstrados. A proporção de neutrófilos, linfócitos e plaquetas (RNLP) já foi associada à presença de lesão renal aguda em outros âmbitos (cirurgia cardíaca e cirurgia abdominal de grande porte) e em pacientes com sepse secundária à COVID-19 pode ser um marcador que identifica os pacientes em risco de apresentar esta complicação.  Objetivo:  Determinar se a proporção de neutrófilos, linfócitos e plaquetas é um preditor de lesão renal aguda na sepse secundária à COVID-19 na UTI adulto.  Material e métodos:  Estudo de coorte prospectivo, unicêntrico. Pacientes maiores de 18 anos admitidos na UTI com diagnóstico de sepse por COVID-19, o RNLP será calculado do dia 1 ao dia 7, dividido em 2 grupos: RNLP maior que 3 e RNLP igual ou inferior a 3, observando a presença ou não de lesão renal aguda durante sua internação, e posteriormente o desfecho, para o objetivo principal, é realizado um teste de &#967;2, e se realiza um teste de regressão logística multivariável para avaliar a associação das diferentes variáveis com o resultado (OR com 95% IC).  Resultados:  Estudou-se uma população de 119 pacientes, com incidência de S-LRA de 53.8% (IC 95% 44-62%) em pacientes com sepse secundária a COVID-19, sendo a maioria KDIGO I (53.2%). No grupo RNLP maior que 3, houve uma incidência de 68.4% de S-LRA comparado ao grupo RNLP menor ou igual a 3 com 28% (p = 0.001, OR 4.255, IC 95% 1.782-10.16), os pacientes com RNLP maior que 3 tiveram maior tempo de permanência na UTI (12 vs 10 dias, p = 0.018) e maior tempo em ventilação mecânica (11 vs 8 dias, p = 0.003).  Conclusão:  O aumento da proporção de neutrófilos, linfócitos e plaquetas é um fator de risco e pode ser prognóstico para a presença de lesão renal aguda na sepse por COVID-19 na UTI.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Relación neutrófilos]]></kwd>
<kwd lng="es"><![CDATA[linfocitos y plaquetas]]></kwd>
<kwd lng="es"><![CDATA[lesión renal aguda inducida por sepsis]]></kwd>
<kwd lng="es"><![CDATA[enfermedad por coronavirus 2019]]></kwd>
<kwd lng="en"><![CDATA[Neutrophil]]></kwd>
<kwd lng="en"><![CDATA[lymphocyte and platelet ratio]]></kwd>
<kwd lng="en"><![CDATA[acute kidney injury]]></kwd>
<kwd lng="en"><![CDATA[coronavirus disease 2019]]></kwd>
<kwd lng="pt"><![CDATA[Proporção de neutrófilos]]></kwd>
<kwd lng="pt"><![CDATA[linfócitos e plaquetas]]></kwd>
<kwd lng="pt"><![CDATA[lesão renal aguda induzida por sepse]]></kwd>
<kwd lng="pt"><![CDATA[doença de coronavírus 2019]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hotchkiss]]></surname>
<given-names><![CDATA[RS]]></given-names>
</name>
<name>
<surname><![CDATA[Moldawer]]></surname>
<given-names><![CDATA[LL]]></given-names>
</name>
<name>
<surname><![CDATA[Opal]]></surname>
<given-names><![CDATA[SM]]></given-names>
</name>
<name>
<surname><![CDATA[Reinhart]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Turnbull]]></surname>
<given-names><![CDATA[IR]]></given-names>
</name>
<name>
<surname><![CDATA[Vincent]]></surname>
<given-names><![CDATA[JL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Sepsis and septic shock]]></article-title>
<source><![CDATA[Nat Rev Dis Primers]]></source>
<year>2016</year>
<volume>2</volume>
<page-range>16045</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Horiguchi]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Loftus]]></surname>
<given-names><![CDATA[TJ]]></given-names>
</name>
<name>
<surname><![CDATA[Hawkins]]></surname>
<given-names><![CDATA[RB]]></given-names>
</name>
<name>
<surname><![CDATA[Raymond]]></surname>
<given-names><![CDATA[SL]]></given-names>
</name>
<name>
<surname><![CDATA[Stortz]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Hollen]]></surname>
<given-names><![CDATA[MK]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Sepsis and critical illness research center investigators. Innate immunity in the persistent inflammation, immunosuppression, and catabolism syndrome and its implications for therapy]]></article-title>
<source><![CDATA[Front Immunol]]></source>
<year>2018</year>
<volume>9</volume>
<page-range>595</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Delano]]></surname>
<given-names><![CDATA[MJ]]></given-names>
</name>
<name>
<surname><![CDATA[Ward]]></surname>
<given-names><![CDATA[PA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The immune system&#8217;s role in sepsis progression, resolution, and long-term outcome]]></article-title>
<source><![CDATA[Immunol Rev]]></source>
<year>2016</year>
<volume>274</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>330-53</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Vincent]]></surname>
<given-names><![CDATA[JL]]></given-names>
</name>
<name>
<surname><![CDATA[de Backer]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Finfer]]></surname>
<given-names><![CDATA[SR]]></given-names>
</name>
<name>
<surname><![CDATA[Vincent]]></surname>
<given-names><![CDATA[JL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Circulatory Shock]]></article-title>
<source><![CDATA[New Engl J Med]]></source>
<year>2013</year>
<volume>369</volume>
<numero>18</numero>
<issue>18</issue>
<page-range>1726-34</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Singer]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Deutschman]]></surname>
<given-names><![CDATA[CS]]></given-names>
</name>
<name>
<surname><![CDATA[Seymour]]></surname>
<given-names><![CDATA[CW]]></given-names>
</name>
<name>
<surname><![CDATA[Shankar-Hari]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Annane]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Bauer]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The third international consensus definitions for sepsis and septic shock (sepsis-3)]]></article-title>
<source><![CDATA[JAMA]]></source>
<year>2016</year>
<volume>315</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>801-10</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Moore]]></surname>
<given-names><![CDATA[PK]]></given-names>
</name>
<name>
<surname><![CDATA[Hsu]]></surname>
<given-names><![CDATA[RK]]></given-names>
</name>
<name>
<surname><![CDATA[Liu]]></surname>
<given-names><![CDATA[KD]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Management of acute kidney injury: core curriculum 2018]]></article-title>
<source><![CDATA[Am J Kidney Dis]]></source>
<year>2018</year>
<volume>72</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>136-48</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chávez]]></surname>
<given-names><![CDATA[PJP]]></given-names>
</name>
<name>
<surname><![CDATA[Sánchez]]></surname>
<given-names><![CDATA[VLD]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Historia natural de la insuficiencia renal aguda (IRA) en las unidades de terapia intensiva (UTI) mexicanas. Estudio multicéntrico]]></article-title>
<source><![CDATA[Med Crit]]></source>
<year>2010</year>
<volume>24</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>18-24</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Khwaja]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[KDIGO clinical practice guidelines for acute kidney injury]]></article-title>
<source><![CDATA[Nephron Clin Pract]]></source>
<year>2012</year>
<volume>120</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>c179-84</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Martensson]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Bellomo]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Sepsis-induced acute kidney injury]]></article-title>
<source><![CDATA[Crit Care Clin]]></source>
<year>2015</year>
<volume>31</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>649-60</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Poston]]></surname>
<given-names><![CDATA[JT]]></given-names>
</name>
<name>
<surname><![CDATA[Koyner]]></surname>
<given-names><![CDATA[JL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Sepsis associated acute kidney injury]]></article-title>
<source><![CDATA[BMJ]]></source>
<year>2019</year>
<volume>364</volume>
<page-range>k4891</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Peerapornratana]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Manrique-Caballero]]></surname>
<given-names><![CDATA[CL]]></given-names>
</name>
<name>
<surname><![CDATA[Gómez]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Kellum]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Acute kidney injury from sepsis: current concepts, epidemiology, pathophysiology, prevention and treatment]]></article-title>
<source><![CDATA[Kidney Int]]></source>
<year>2019</year>
<volume>96</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>1083-99</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bellomo]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Kellum]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Ronco]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Wald]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Martensson]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Maiden]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Acute kidney injury in sepsis. Intensive Care Medicine]]></article-title>
<source><![CDATA[Springer Verlag]]></source>
<year>2017</year>
<volume>43</volume>
<page-range>816-28</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Beltrán-García]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Osca-Verdegal]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Pallardó]]></surname>
<given-names><![CDATA[FV]]></given-names>
</name>
<name>
<surname><![CDATA[Ferreres]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Rodríguez]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Mulet]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Ferrando-Sánchez]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Sepsis and coronavirus disease 2019: common features and anti-inflammatory therapeutic approaches]]></article-title>
<source><![CDATA[Crit Care Med]]></source>
<year>2020</year>
<volume>48</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>1841-4</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zafer]]></surname>
<given-names><![CDATA[MM]]></given-names>
</name>
<name>
<surname><![CDATA[El-Mahallawy]]></surname>
<given-names><![CDATA[HA]]></given-names>
</name>
<name>
<surname><![CDATA[Ashour]]></surname>
<given-names><![CDATA[HM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Severe COVID-19 and sepsis: immune pathogenesis and laboratory markers]]></article-title>
<source><![CDATA[Microorganisms]]></source>
<year>2021</year>
<volume>9</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>159</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Khanmohammadi]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Rezaei]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Role of Toll-like receptors in the pathogenesis of COVID-19]]></article-title>
<source><![CDATA[J Med Virol]]></source>
<year>2021</year>
<volume>93</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>2735-9</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Vincent]]></surname>
<given-names><![CDATA[JL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[COVID-19: it&#8217;s all about sepsis. Future microbiology]]></article-title>
<source><![CDATA[Future Medicine]]></source>
<year>2021</year>
<volume>16</volume>
<page-range>131-3</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gabarre]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Dumas]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Dupont]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Darmon]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Azoulay]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Zafrani]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Acute kidney injury in critically ill patients with COVID-19]]></article-title>
<source><![CDATA[Intensive Care Med]]></source>
<year>2020</year>
<volume>46</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>1339-48</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hirsch]]></surname>
<given-names><![CDATA[JS]]></given-names>
</name>
<name>
<surname><![CDATA[Ng]]></surname>
<given-names><![CDATA[JH]]></given-names>
</name>
<name>
<surname><![CDATA[Ross]]></surname>
<given-names><![CDATA[DW]]></given-names>
</name>
<name>
<surname><![CDATA[Sharma]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Shah]]></surname>
<given-names><![CDATA[HH]]></given-names>
</name>
<name>
<surname><![CDATA[Barnett]]></surname>
<given-names><![CDATA[RL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Acute kidney injury in patients hospitalized with COVID-19]]></article-title>
<source><![CDATA[Kidney Int]]></source>
<year>2020</year>
<volume>98</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>209-18</page-range></nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Panitchote]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Mehkri]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Hastings]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Hanane]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Demirjian]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Torbic]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Factors associated with acute kidney injury in acute respiratory distress syndrome]]></article-title>
<source><![CDATA[Ann Intensive Care]]></source>
<year>2019</year>
<volume>9</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>74</page-range></nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Watchorn]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Huang]]></surname>
<given-names><![CDATA[DY]]></given-names>
</name>
<name>
<surname><![CDATA[Joslin]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Bramham]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Hutchings]]></surname>
<given-names><![CDATA[SD]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Critically ill COVID-19 patients with acute kidney injury have reduced renal blood flow and perfusion despite preserved cardiac function: a case-control study using contrast-enhanced ultrasound]]></article-title>
<source><![CDATA[Shock (Augusta, Ga)]]></source>
<year>2021</year>
<volume>55</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>479-87</page-range></nlm-citation>
</ref>
<ref id="B21">
<label>21</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Nadim]]></surname>
<given-names><![CDATA[MK]]></given-names>
</name>
<name>
<surname><![CDATA[Forni]]></surname>
<given-names><![CDATA[LG]]></given-names>
</name>
<name>
<surname><![CDATA[Mehta]]></surname>
<given-names><![CDATA[RL]]></given-names>
</name>
<name>
<surname><![CDATA[Connor]]></surname>
<given-names><![CDATA[MJ]]></given-names>
</name>
<name>
<surname><![CDATA[Liu]]></surname>
<given-names><![CDATA[KD]]></given-names>
</name>
<name>
<surname><![CDATA[Ostermann]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup]]></article-title>
<source><![CDATA[Nature Reviews Nephrology]]></source>
<year>2020</year>
<volume>16</volume>
<page-range>747-64</page-range></nlm-citation>
</ref>
<ref id="B22">
<label>22</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gameiro]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Lopes]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Complete blood count in acute kidney injury prediction: a narrative review]]></article-title>
<source><![CDATA[Ann Intensive Care]]></source>
<year>2019</year>
<volume>9</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>87</page-range></nlm-citation>
</ref>
<ref id="B23">
<label>23</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Imran]]></surname>
<given-names><![CDATA[MM]]></given-names>
</name>
<name>
<surname><![CDATA[Ahmad]]></surname>
<given-names><![CDATA[U]]></given-names>
</name>
<name>
<surname><![CDATA[Usman]]></surname>
<given-names><![CDATA[U]]></given-names>
</name>
<name>
<surname><![CDATA[Ali]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Shaukat]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Gul]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Neutrophil/lymphocyte ratio-A marker of COVID-19 pneumonia severity]]></article-title>
<source><![CDATA[Int J Clin Pract]]></source>
<year>2021</year>
<volume>75</volume>
<numero>4</numero>
<issue>4</issue>
</nlm-citation>
</ref>
<ref id="B24">
<label>24</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Koo]]></surname>
<given-names><![CDATA[CH]]></given-names>
</name>
<name>
<surname><![CDATA[Eun Jung]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Park]]></surname>
<given-names><![CDATA[YS]]></given-names>
</name>
<name>
<surname><![CDATA[Bae]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Cho]]></surname>
<given-names><![CDATA[YJ]]></given-names>
</name>
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[WH]]></given-names>
</name>
<name>
<surname><![CDATA[Bahk]]></surname>
<given-names><![CDATA[JH]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Neutrophil, lymphocyte, and platelet counts and acute kidney injury after cardiovascular surgery]]></article-title>
<source><![CDATA[J Cardiothorac Vasc Anesth]]></source>
<year>2018</year>
<volume>32</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>212-22</page-range></nlm-citation>
</ref>
<ref id="B25">
<label>25</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gameiro]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Fonseca]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Dias]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
<name>
<surname><![CDATA[Milho]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Rosa]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Jorge]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Lopes]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Neutrophil, lymphocyte and platelet ratio as a predictor of postoperative acute kidney injury in major abdominal surgery]]></article-title>
<source><![CDATA[BMC Nephrol]]></source>
<year>2018</year>
<volume>19</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>320</page-range></nlm-citation>
</ref>
<ref id="B26">
<label>26</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gameiro]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Fonseca]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Jorge]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Gouveia]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Lopes]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Neutrophil, lymphocyte and platelet ratio as a predictor of mortality in septic-acute kidney injury patients]]></article-title>
<source><![CDATA[Nefrologia (Engl Ed)]]></source>
<year>2020</year>
<volume>40</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>461-8</page-range></nlm-citation>
</ref>
<ref id="B27">
<label>27</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Silver]]></surname>
<given-names><![CDATA[SA]]></given-names>
</name>
<name>
<surname><![CDATA[Beaubien-Souligny]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Shah]]></surname>
<given-names><![CDATA[PS]]></given-names>
</name>
<name>
<surname><![CDATA[Harel]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Blum]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Kishibe]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The Prevalence of Acute Kidney Injury in Patients Hospitalized With COVID-19 Infection: A Systematic Review and Meta-analysis]]></article-title>
<source><![CDATA[Kidney medicine]]></source>
<year>2021</year>
<volume>3</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>83-98</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
