<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2448-8909</journal-id>
<journal-title><![CDATA[Medicina crítica (Colegio Mexicano de Medicina Crítica)]]></journal-title>
<abbrev-journal-title><![CDATA[Med. crít. (Col. Mex. Med. Crít.)]]></abbrev-journal-title>
<issn>2448-8909</issn>
<publisher>
<publisher-name><![CDATA[Colegio Mexicano de Medicina Crítica A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2448-89092021000300130</article-id>
<article-id pub-id-type="doi">10.35366/100001</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Índice neutrófilos/linfocitos: un predictor de mortalidad en paciente con infección por SARS-CoV-2]]></article-title>
<article-title xml:lang="en"><![CDATA[The neutrophiles/lymphocytes index: is a predictor of mortality in a patient with infection by SARS-CoV-2]]></article-title>
<article-title xml:lang="pt"><![CDATA[O índice de neutrófilos/linfócitos um preditor de mortalidade em um paciente com infecção por SARS-CoV-2]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Montalvo Aguilar]]></surname>
<given-names><![CDATA[Michell]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González López]]></surname>
<given-names><![CDATA[César Augusto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,ISSSTE Hospital Regional «Lic. Adolfo López Mateos» ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2021</year>
</pub-date>
<volume>35</volume>
<numero>3</numero>
<fpage>130</fpage>
<lpage>135</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2448-89092021000300130&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2448-89092021000300130&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2448-89092021000300130&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[resumen está disponible en el texto completo]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract:  Introduction:  In December 2019 it was announced that in the city of Wuhan (China) a new series of pneumonia cases had occurred, apparently caused by a new type of coronavirus. On January 07, 2020, the new coronavirus was officially announced by the Chinese authorities as the causative agent of these infections. The neutrophil/lymphocyte ratio (INL) has taken on interest as a serum biomarker to define severity. Cataudella et al, reported the proportional relationship of INL with the severity of pneumonia and some adverse outcomes, in addition, it has been observed that it can be a predictor of mortality in Intensive Care Units.  Material and methods: A prospective, longitudinal, analytical study was carried out in which all patients with diagnoses of SARS-CoV-2 infection were admitted in a period of time from April-August 2020, in the intensive care unit of the Regional Hospital «Lic. Adolfo López Mateos».  Results:  The study population consisted of 59 subjects, however, for the analysis, two patients were excluded due to insufficient data. Of the remaining 57, 61.4% (n = 35) were men and 38.6% (n = 22) were women. Regarding the ROC curve, which is an analysis whose purpose determines a cut-off value with high sensitivity to predict an event (in our mortality objective), a significant result was carried out and produced only in the neutrophil/lymphocyte index when the patient was in the ICU with an area under the curve of 0.728 (CI 0.597-0.860) (p = 0.004), it showed a specificity of 80% when the index had a value of 10.35 or greater in these patients. The calculation for this parameter in while the patient was admitted to the emergency room was not significant and the hypothesis was denied with an area under the curve of 0.628 (CI 0.480-0.777).  Conclusions:  Among our results, it stands out that the average reported value in patients who died during their stay in the ICU was 54.56 ± 10.89 years vs those alive, which was 48.23 ± 11.42 (p = 0.037), which is consistent with that reported in the literature by various authors. it was decided to look for a cut-off point in the Mexican population, where Reyes-Gálvez et al. reported in sepsis that a value of 18.1 to 36 or even higher is a value of the neutrophil/lymphocyte index that is associated with a severe or critical state of the disease and is modestly associated with the APACHE scale. According to these cut-off points, the population analyzed did not report significant associations while they were in the emergency services, possibly because the acute inflammatory response had not yet been fully developed, or the primary symptomatology is only respiratory failure that merited his hospitalization and subsequent transfer to the ICU where this value was significant (p = 0.022).]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo:  Introdução:  Em dezembro de 2019 foi anunciado que na cidade de Wuhan (China) havia ocorrido uma nova série de casos de pneumonia, aparentemente causados por um novo tipo de coronavírus. Em 7 de janeiro de 2020, o novo coronavírus foi anunciado oficialmente pelas autoridades chinesas como o agente causador dessas infecções. A razão neutrófilos/linfócitos (INL) tem se tornado um biomarcador sérico para definir a gravidade. Cataudella et al, relataram a relação proporcional do INL com a gravidade da pneumonia e alguns desfechos adversos, além disso, observou-se que pode ser um preditor de mortalidade em unidades de terapia intensiva.  Material e métodos:  Foi realizado um estudo prospectivo, longitudinal e analítico no qual todos os pacientes com diagnóstico de infecção por SARS-CoV-2 foram internados no período de abril de 2020 a agosto de 2020, na Unidade de Terapia Intensiva do Hospital Regional «Lic. Adolfo López Mateos».  Resultados:  População do estudo consistiu de 59 indivíduos, entretanto, 2 pacientes foram excluídos para análise devido a dados insuficientes. Dos 57 restantes, 61.4% (n = 35) eram homens e 38.6% (n = 22) eram mulheres. Em relação à curva ROC, que é uma análise cujo objetivo determina um valor de corte com alta sensibilidade para predizer um evento (em nosso objetivo de mortalidade), um resultado significativo foi realizado e produzido apenas no índice de neutrófilos/linfócitos quando o paciente estava na UTI com área sob a curva de 0.728 (IC: 0.597-0.860) (p = 0.004), apresentou especificidade de 80% quando o índice teve valor igual ou superior a 10.35 nesses pacientes. O cálculo desse parâmetro durante a internação do paciente no pronto-socorro não foi significativo e a hipótese foi negada com área sob a curva de 0.628 (IC: 0.480-0.777).  Conclusões:  Dentre os nossos resultados, destaca-se que o valor médio relatado em pacientes que morreram durante a internação na UTI foi de 54.56 ± 10.89 anos vs vivos, que foi de 48.23 ± 11.42 (p = 0.037), o que está de acordo com o relatado na literatura de vários autores. Optou-se por buscar um ponto de corte na população mexicana, onde Reyes-Gálvez et al. relataram na sepse que um valor de 18.1 a 36 ou até mais alto é um valor do índice de neutrófilos/linfócitos que está associado a um estado grave ou crítico da doença e está modestamente associado à escala APACHE. De acordo com esses pontos de corte, a população analisada não relatou associações significativas enquanto estiveram nos serviços de emergência, possivelmente porque a resposta inflamatória aguda ainda não havia se desenvolvido totalmente, ou a sintomatologia primária era apenas insuficiência respiratória que necessitava hospitalização e posterior transferência para a UTI onde este valor foi significativo (p = 0.022).]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Índice]]></kwd>
<kwd lng="es"><![CDATA[neutrófilo/linfocito]]></kwd>
<kwd lng="es"><![CDATA[SARS-CoV-2]]></kwd>
<kwd lng="es"><![CDATA[predictor]]></kwd>
<kwd lng="es"><![CDATA[mortalidad]]></kwd>
<kwd lng="es"><![CDATA[Unidad de Cuidados Intensivos]]></kwd>
<kwd lng="en"><![CDATA[Index]]></kwd>
<kwd lng="en"><![CDATA[neutrophile/lymphocyte]]></kwd>
<kwd lng="en"><![CDATA[SARS-CoV-2]]></kwd>
<kwd lng="en"><![CDATA[predictive]]></kwd>
<kwd lng="en"><![CDATA[mortality]]></kwd>
<kwd lng="en"><![CDATA[Intensive Care Unit]]></kwd>
<kwd lng="pt"><![CDATA[Índice]]></kwd>
<kwd lng="pt"><![CDATA[neutrófilo/linfócito]]></kwd>
<kwd lng="pt"><![CDATA[SARS-CoV-2]]></kwd>
<kwd lng="pt"><![CDATA[preditivo]]></kwd>
<kwd lng="pt"><![CDATA[mortalidade]]></kwd>
<kwd lng="pt"><![CDATA[Unidade de Terapia Intensiva]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Luis]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Martin]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Ignacio]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[María]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Javier]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Índice neutrófilo-linfocito como factor pronóstico de covid-19]]></article-title>
<source><![CDATA[Medicina (Buenos Aires)]]></source>
<year>2020</year>
<volume>80</volume>
<numero>^sIII</numero>
<issue>^sIII</issue>
<supplement>III</supplement>
<page-range>31-6</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[José]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Arturo]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Índice neutrófilo/linfocito como biomarcador sérico asociado con neumonía adquirida en comunidad]]></article-title>
<source><![CDATA[Rev Med Inst Mex Seguro Soc]]></source>
<year>2018</year>
<volume>56</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>537-43</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[José]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[María]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Juan]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Predictores se mortalidad en pacientes con COVID-19]]></article-title>
<source><![CDATA[Archivos de Medicina]]></source>
<year>2020</year>
<volume>16</volume>
<numero>26</numero>
<issue>26</issue>
<page-range>1-3</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Reyes-Gálvez]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Gracida-Mancilla]]></surname>
<given-names><![CDATA[NI]]></given-names>
</name>
<name>
<surname><![CDATA[Enríquez- Santos]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Carrillo-Esper]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Índice neutrófilos-linfocitos como predictor de gravedad y mortalidad en pacientes con sepsis abdominal]]></article-title>
<source><![CDATA[Med Int Méx]]></source>
<year>2016</year>
<volume>32</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>41-7</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jiangshan]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Ciliang]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Shaorui]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Xiaoli]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
<name>
<surname><![CDATA[Meifang]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Xi]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[High neutrophil-to-lymphocyte ratio associated with progression to critical illness in older patients with COVID-19: a multicenter retrospective study]]></article-title>
<source><![CDATA[Aging]]></source>
<year>2020</year>
<volume>12</volume>
<numero>14</numero>
<issue>14</issue>
<page-range>13849-59</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Roujian]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Xiang]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
<name>
<surname><![CDATA[Juan]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding]]></article-title>
<source><![CDATA[Lancet]]></source>
<year>2020</year>
<volume>395</volume>
<page-range>565-74</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Guo]]></surname>
<given-names><![CDATA[YR]]></given-names>
</name>
<name>
<surname><![CDATA[Cao]]></surname>
<given-names><![CDATA[QD]]></given-names>
</name>
<name>
<surname><![CDATA[Hong]]></surname>
<given-names><![CDATA[ZS]]></given-names>
</name>
<name>
<surname><![CDATA[Tan]]></surname>
<given-names><![CDATA[YY]]></given-names>
</name>
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[SD]]></given-names>
</name>
<name>
<surname><![CDATA[Jin]]></surname>
<given-names><![CDATA[HJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak-an update on the status]]></article-title>
<source><![CDATA[Military Med Res]]></source>
<year>2020</year>
<volume>7</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>11</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Palacios]]></surname>
<given-names><![CDATA[CM]]></given-names>
</name>
<name>
<surname><![CDATA[Santos]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Velázquez]]></surname>
<given-names><![CDATA[CMA]]></given-names>
</name>
<name>
<surname><![CDATA[León]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[COVID-19, una emergencia de salud pública mundial]]></article-title>
<source><![CDATA[Revista Clínica Española]]></source>
<year>2021</year>
<volume>221</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>55-61</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Socorro]]></surname>
<given-names><![CDATA[FS]]></given-names>
</name>
<name>
<surname><![CDATA[Fernandes Jr]]></surname>
<given-names><![CDATA[PC]]></given-names>
</name>
<name>
<surname><![CDATA[Barbosa]]></surname>
<given-names><![CDATA[SMJ]]></given-names>
</name>
<name>
<surname><![CDATA[Lima]]></surname>
<given-names><![CDATA[VC]]></given-names>
</name>
<name>
<surname><![CDATA[Fontes]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Freitas-Junior]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The neutrophil-to-lymphocyte ratio: a narrative review]]></article-title>
<source><![CDATA[Ecancer]]></source>
<year>2016</year>
<volume>10</volume>
</nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Zhou]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Zhu]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Song]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Feng]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Qiu]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Immune phenotyping based on the neutrophil-to-lymphocyte ratio and igg level predicts disease severity and outcome for patients with COVID-19]]></article-title>
<source><![CDATA[Front Mol Biosci]]></source>
<year>2020</year>
<volume>7</volume>
</nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chan]]></surname>
<given-names><![CDATA[AS]]></given-names>
</name>
<name>
<surname><![CDATA[Rout]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Use of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in COVID-19]]></article-title>
<source><![CDATA[J Clin Med Res]]></source>
<year>2020</year>
<volume>12</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>448-53</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fu]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Kong]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Wu]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Yao]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The clinical implication of dynamic neutrophil to lymphocyte ratio and D-dimer in COVID-19: a retrospective study in Suzhou China]]></article-title>
<source><![CDATA[Thrombosis Research]]></source>
<year>2020</year>
<volume>192</volume>
<page-range>3-8</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Yang A-]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Liu]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Tao]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The diagnostic and predictive role of NLR, d-NLR and PLR in COVID-19 patients]]></article-title>
<source><![CDATA[Int Immunopharmacol]]></source>
<year>2020</year>
<volume>84</volume>
<page-range>106504</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Liu]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Du]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Jin]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Peng]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[HHX]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Neutrophil-to-lymphocyte ratio as an independent risk factor for mortality in hospitalized patients with COVID-19]]></article-title>
<source><![CDATA[Journal of Infection]]></source>
<year>2020</year>
<volume>81</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>e6-12</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Devaux]]></surname>
<given-names><![CDATA[CA]]></given-names>
</name>
<name>
<surname><![CDATA[Rolain J-]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Colson]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Raoult]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19?]]></article-title>
<source><![CDATA[International Journal of Antimicrobial Agents]]></source>
<year>2020</year>
<volume>55</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>105938</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pan]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Yang]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Liang]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Ye]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Factors associated with death outcome in patients with severe coronavirus disease-19 (COVID-19): a case-control study]]></article-title>
<source><![CDATA[Int J Med Sci]]></source>
<year>2020</year>
<volume>17</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>1281-92</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lippi]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Wong]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Henry]]></surname>
<given-names><![CDATA[BM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hypertension and its severity or mortality in Coronavirus Disease 2019 (COVID-19): a pooled analysis]]></article-title>
<source><![CDATA[Polish Archives of Internal Medicine]]></source>
<year>2020</year>
<volume>130</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>304-9</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Martínez-Urbistondo]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Beltrán]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Beloqui]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Huerta]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[El índice neutrófilo/linfocito como marcador de disfunción sistémica endotelial en sujetos asintomáticos]]></article-title>
<source><![CDATA[Nefrología]]></source>
<year>2016</year>
<volume>36</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>397-403</page-range></nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Liu]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Liu]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Xiang]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Pu]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Xiong]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Neutrophil-to-lymphocyte ratio predicts critical illness patients with 2019 coronavirus disease in the early stage]]></article-title>
<source><![CDATA[J Transl Med]]></source>
<year>2020</year>
<volume>18</volume>
<numero>1</numero>
<issue>1</issue>
</nlm-citation>
</ref>
</ref-list>
</back>
</article>
