<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2448-8909</journal-id>
<journal-title><![CDATA[Medicina crítica (Colegio Mexicano de Medicina Crítica)]]></journal-title>
<abbrev-journal-title><![CDATA[Med. crít. (Col. Mex. Med. Crít.)]]></abbrev-journal-title>
<issn>2448-8909</issn>
<publisher>
<publisher-name><![CDATA[Colegio Mexicano de Medicina Crítica A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2448-89092021000300121</article-id>
<article-id pub-id-type="doi">10.35366/100000</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Asociación de ferritina con deterioro ventilatorio y mortalidad debido a COVID-19 en terapia intensiva]]></article-title>
<article-title xml:lang="en"><![CDATA[Association of ferritin with ventilatory impairment and mortality due to COVID-19 in intensive care]]></article-title>
<article-title xml:lang="pt"><![CDATA[Associação da ferritina com a deterioração ventilatória e mortalidade devido ao COVID-19 na UTI]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Galicia García]]></surname>
<given-names><![CDATA[Cesar]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Santana Hernández]]></surname>
<given-names><![CDATA[Gabriela Patricia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vega Sánchez]]></surname>
<given-names><![CDATA[Ángel Emmanuel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital San Ángel Inn Universidad  ]]></institution>
<addr-line><![CDATA[CDMX ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2021</year>
</pub-date>
<volume>35</volume>
<numero>3</numero>
<fpage>121</fpage>
<lpage>129</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2448-89092021000300121&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2448-89092021000300121&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2448-89092021000300121&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[resumen está disponible en el texto completo]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract:  Introduction:  The association of serum ferritin as a parameter of poor prognosis and survival has been studied in patients with COVID-19. Studies affirm a decreased survival and poor prognosis in patients with COVID and ferritin levels greater than 1,000 ng/mL. This implies that the hemoglobin is decreasing, and the heme group is increasing, therefore the body will accumulate too many harmful iron ions, which will cause inflammation in the body and increase the C-reactive protein and albumin. Cells react to stress due to inflammation, producing large amounts of serum ferritin to bind free iron ions to reduce damage.  Objetive: The objective of the study was to evaluate serum ferritin measured at admission as a predictor of evolution in the ICU, for which intubation and death were taken as the main outcomes. A sensitivity and specificity calculation were performed and the area under the curve was calculated by means of the ROC curve. The strength of association of ferritin was evaluated by calculating the crude OR and adjusted by multivariate univariate logistic regression. Ferritin was evaluated as a prognostic marker of intubation and mortality in patients admitted to intensive care.  Material and methods:  A retrospective, cross-sectional study was carried out, in which 48 patients were recruited in the intensive care unit of the San Angel Inn University Hospital. Which were taken the clinical data and variables of interest from the clinical record. A description of the data was made based on its distribution in means with standard deviation or medians with interquartile ranges of the continuous variables and in frequencies with percentage of the categorical data.  Results:  For mortality it was chosen from the ROC curve with a sensitivity value of 50%, specificity 88.89, LR + of 4.5 and LR - 0.56, with it the area was 8 using this cut-off value, the proportion of patients with mortality below this value was 7.8 for mortality risk and sensitivity of 72.73%, specificity 73.08, LR + of 2.7 and LR - 0.37, with this the area was 7.2 using this The cut-off value of the proportion of patients intubated under this value was 9.3, with this a univariate logistic regression was performed, observing a crude OR of 8 and adjusted for mortality, and crude OR of 7.23 and adjusted for 9.3 for intubation and adjusted to confounders for age with OR 1.0, with p value of 0.080, hypertension with OR of 3.2, p value of 0.10 and for obesity with OR of 1.89, with p value of 0.041.  Conclusion:  In patients admitted to the San Angel Inn University hospital with severity criteria for intensive therapy, the presence of ferritin greater than 1100 ng / ml has a sensitivity of 72.73%, specificity of 73.08% and LR + of 2.70 and LR - of 0.37 of this value was associated with intubation with crude OR of 7.2 and adjusted of 9.3 and the presence of ferritin greater than 2507 ng / ml, it has a sensitivity of 50%, specificity of 88.89% and LR + of 4.5 and LR - of 0.56 of This value was associated with mortality with a crude OR of 8 and adjusted for 7.8. For this reason. A ferritin cut-off value greater than 1100, in patients admitted to ICU. It should be considered as a prognosis for intubation during hospitalization. This marker should be evaluated with a greater number of patients to verify its usefulness.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo:  Introdução:  A associação da ferritina sérica como parâmetro de mau prognóstico e de sobrevida tem sido estudada em pacientes com COVID-19. Estudos afirmam uma sobrevida diminuída e prognóstico ruim em pacientes com COVID e níveis de ferritina maiores que 1,000 ng/mL. Isso implica que a hemoglobina está diminuindo e o grupo heme está aumentando; portanto, o corpo acumulará muitos íons de ferro prejudiciais, o que causará inflamação no corpo e aumentará a proteína C reativa e a albumina. As células reagem ao estresse devido à inflamação, produzindo grandes quantidades de ferritina sérica para ligar os íons de ferro livres e reduzir os danos.  Objetivo:  O objetivo do estudo foi avaliar a ferritina sérica medida na admissão como preditor de evolução na UTI, tendo intubação e óbito como desfechos principais. Foi realizado cálculo de sensibilidade e especificidade e calculada a área sob a curva por meio da curva ROC. A força de associação da ferritina foi avaliada pelo cálculo do OR bruto e ajustada por regressão logística multivariada univariada. A ferritina foi avaliada como marcador prognóstico de intubação e mortalidade em pacientes internados em terapia intensiva.  Material e métodos:  Foi realizado um estudo transversal retrospectivo, no qual 48 pacientes foram recrutados na unidade de terapia intensiva do Hospital San Angel Inn Universidad. Os dados clínicos e as variáveis de interesse foram obtidos do prontuário clínico. A descrição dos dados foi feita a partir de sua distribuição em médias com desvio padrão ou medianas com intervalos interquartis das variáveis contínuas e em frequências com porcentagem dos dados categóricos.  Resultados:  Por mortalidade, sendo escolhida a partir da curva ROC com valor de sensibilidade de 50%, especificidade de 88.89, LR + de 4.5 e LR - 0.56, com ela a área foi 8 usando este valor de corte, a proporção de pacientes com mortalidade abaixo desse valor foi de 7.8 para risco de mortalidade e sensibilidade de 72.73%, especificidade 73.08, LR + de 2.7 e LR - 0.37, com isso a área foi de 7.2 usando este o valor de corte da proporção de pacientes intubados sob este valor foi de 9.3, com isso foi realizada uma regressão logística univariada, observando um OR bruto de 8 e ajustado para mortalidade, e OR bruto de 7.23 e ajustado para 9.3 para intubação e ajustado para confundidores para idade com OR 1.0, com valor de p de 0.080, hipertensão com OR de 3.2, valor de p de 0.10 e para obesidade com OR de 1.89, com valor de p de 0.041.  Conclusão:  Em pacientes internados no Hospital San Ángel Inn Universidad com critérios de gravidade para Terapia Intensiva, a presença de ferritina maior que 1,100 ng/mL, tem sensibilidade de 72.73%, especificidade de 73.08% e LR + de 2.70 e LR - de 0.37 deste valor foi associado à intubação com OR bruto de 7.2 e ajustado de 9.3 e à presença de ferritina maior que 2,507 ng/mL, tem sensibilidade de 50%, especificidade de 88.89% e LR + de 4.5 e LR - de 0.56 desse valor foi associado à mortalidade com um OR bruto de 8 e ajustado para 7.8. Por tal motivo. Um valor de corte de ferritina superior a 1,100, em pacientes admitidos na UTI. Deve ser considerado como um prognóstico para intubação durante a hospitalização. Esse marcador deve ser avaliado com um número maior de pacientes para verificar sua utilidade.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Ferritina]]></kwd>
<kwd lng="es"><![CDATA[mortalidad]]></kwd>
<kwd lng="es"><![CDATA[intubación]]></kwd>
<kwd lng="es"><![CDATA[supervivencia]]></kwd>
<kwd lng="es"><![CDATA[pronóstico]]></kwd>
<kwd lng="en"><![CDATA[Ferritin]]></kwd>
<kwd lng="en"><![CDATA[mortality]]></kwd>
<kwd lng="en"><![CDATA[intubation]]></kwd>
<kwd lng="en"><![CDATA[survival]]></kwd>
<kwd lng="en"><![CDATA[prognosis]]></kwd>
<kwd lng="pt"><![CDATA[Ferritina]]></kwd>
<kwd lng="pt"><![CDATA[mortalidade]]></kwd>
<kwd lng="pt"><![CDATA[intubação]]></kwd>
<kwd lng="pt"><![CDATA[sobrevivência]]></kwd>
<kwd lng="pt"><![CDATA[prognóstico]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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