<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2448-8909</journal-id>
<journal-title><![CDATA[Medicina crítica (Colegio Mexicano de Medicina Crítica)]]></journal-title>
<abbrev-journal-title><![CDATA[Med. crít. (Col. Mex. Med. Crít.)]]></abbrev-journal-title>
<issn>2448-8909</issn>
<publisher>
<publisher-name><![CDATA[Colegio Mexicano de Medicina Crítica A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2448-89092020000600341</article-id>
<article-id pub-id-type="doi">10.35366/98164</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Medidas de protección alveolar en pacientes con COVID-19]]></article-title>
<article-title xml:lang="en"><![CDATA[Alveolar protection measures in patients with COVID-19]]></article-title>
<article-title xml:lang="pt"><![CDATA[Medidas de proteção alveolar em pacientes com COVID-19]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García Salas]]></surname>
<given-names><![CDATA[Yessica]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cruz Muñoz]]></surname>
<given-names><![CDATA[Beatriz]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ortiz Larios]]></surname>
<given-names><![CDATA[Fabricio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Torres Adalid]]></surname>
<given-names><![CDATA[José David]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Civil de Guadalajara «Fray Antonio Alcalde»  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2020</year>
</pub-date>
<volume>34</volume>
<numero>6</numero>
<fpage>341</fpage>
<lpage>348</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2448-89092020000600341&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2448-89092020000600341&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2448-89092020000600341&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: COVID-19, la enfermedad ocasionada por SARS-CoV-2, fue declarada pandemia por la OMS a principios de marzo 2020. En México, hasta noviembre 2020 habían sido confirmados más de 995,000 casos y cerca de 100,000 defunciones, situándose dentro de los 10 países con mayor tasa de infectados a nivel mundial. La gran mayoría de pacientes cursa con síntomas leves que no amerita hospitalización, pero los pacientes con cuadros severos de insuficiencia respiratoria pueden requerir ventilación mecánica invasiva, tratamiento que en México se ha asociado a una mortalidad de hasta 73.7%. La ventilación mecánica es una terapia que puede salvar vidas, pero no está exenta de riesgos y una programación inadecuada también puede ocasionar daño por diversos mecanismos denominados en conjunto VILI (Ventilator-induced lung injury). Más de 50 años de búsqueda han dictado las directrices para el manejo óptimo de la ventilación mecánica, pero esta nueva pandemia ha abierto el panorama a nuevas investigaciones. La ventilación protectora pulmonar: VT de 6-8 mL/kg, presión meseta &lt; 30 cmH2O, ha mejorado los desenlaces clínicos en pacientes con y sin SDRA en los últimos 20 años, aunque el COVID-19 tiene particularidades la evidencia sugiere otorgar la misma estrategia.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: COVID-19, the disease spectrum caused by the new beta coronavirus SARS-CoV-2 was declared as a pandemic by the WHO in March 2020. Until November 2020 more than 995,000 cases and nearly 100,000 deaths had been confirmed have been confirmed in Mexico, being one of the 10 countries with the highest index of cases. Most patients have a mild disease not requiring hospitalization, but severe cases with respiratory failure may require mechanical ventilation with a high mortality rate up to 73.7% in some series in Mexico. Mechanical ventilation saves lives but, it is not out of risk as it may cause harm through many mechanisms named VILI on the whole (ventilator-induced lung injury). After more than 50 years since its first description, protective mechanical ventilation has become the standard of care in ARDS patients, but this pandemic has opened the gap for new research. Protective mechanical ventilation: low tidal volumes 6-8 mL/kg predicted body weight (PBW) and plateau pressure &lt; 30 cmH2O has improved patients&#8217; outcomes in the last 20 years. Even though COVID-19 has certain differences with the «classical» ARDS, evidence-based medicine suggests the same strategies should be followed.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo: COVID-19, a doença causada pelo SARS-CoV-2, foi declarada pandemia pela OMS no início de março de 2020. No México, até novembro de 2020 foram confirmados mais de 995,000 casos e quase 100,000 mortes, classificando-se em 10 países com a maior taxa de infectados em todo o mundo. A grande maioria dos pacientes apresenta sintomas leves que não justificam a hospitalização, mas os pacientes com insuficiência respiratória grave podem requerer ventilação mecânica invasiva, um tratamento que no México foi associado a uma taxa de mortalidade de até 73.7%. A ventilação mecânica é uma terapia que salva vidas, mas não é isenta de riscos, e uma programação inadequada também pode causar danos por vários mecanismos chamados coletivamente de VILI (Ventilator-induced lung injury). Mais de 50 anos de pesquisa ditaram as diretrizes para o gerenciamento ideal da ventilação mecânica, mas esta nova pandemia abriu o cenário para novas pesquisas. Ventilação protetora pulmonar: VT de 6-8 mL/kg, pressão de platô &lt; 30 cmH2O, melhorou os desfechos clínicos em pacientes com e sem SDRA nos últimos 20 anos, embora COVID-19 tenha particularidades, as evidências sugerem conceder as mesmas estratégia.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Ventilación mecánica]]></kwd>
<kwd lng="es"><![CDATA[protección alveolar]]></kwd>
<kwd lng="es"><![CDATA[COVID-19]]></kwd>
<kwd lng="en"><![CDATA[Mechanical ventilation]]></kwd>
<kwd lng="en"><![CDATA[alveolar protection]]></kwd>
<kwd lng="en"><![CDATA[COVID-19]]></kwd>
<kwd lng="pt"><![CDATA[Ventilação mecânica]]></kwd>
<kwd lng="pt"><![CDATA[proteção alveolar]]></kwd>
<kwd lng="pt"><![CDATA[COVID-19]]></kwd>
</kwd-group>
</article-meta>
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