<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2448-8909</journal-id>
<journal-title><![CDATA[Medicina crítica (Colegio Mexicano de Medicina Crítica)]]></journal-title>
<abbrev-journal-title><![CDATA[Med. crít. (Col. Mex. Med. Crít.)]]></abbrev-journal-title>
<issn>2448-8909</issn>
<publisher>
<publisher-name><![CDATA[Colegio Mexicano de Medicina Crítica A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2448-89092020000500273</article-id>
<article-id pub-id-type="doi">10.35366/96457</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Impacto de las asincronías en el pronóstico del paciente bajo ventilación mecánica invasiva]]></article-title>
<article-title xml:lang="en"><![CDATA[Prognosis impact of the asynchronies in the mechanical ventilated patient]]></article-title>
<article-title xml:lang="pt"><![CDATA[Impacto das assincronias no prognóstico do paciente com ventilação mecânica invasiva]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Nicolás Martínez]]></surname>
<given-names><![CDATA[Edith Lizette]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mercado Velázquez]]></surname>
<given-names><![CDATA[Pamela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vidal Mayo]]></surname>
<given-names><![CDATA[José de Jesús]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rivero Sigarroa]]></surname>
<given-names><![CDATA[Eduardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Domínguez Cherit]]></surname>
<given-names><![CDATA[Guillermo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Nacional de Ciencias Médicas y Nutrición «Salvador Zubirán»  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>10</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>10</month>
<year>2020</year>
</pub-date>
<volume>34</volume>
<numero>5</numero>
<fpage>273</fpage>
<lpage>278</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2448-89092020000500273&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2448-89092020000500273&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2448-89092020000500273&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: La ventilación mecánica es común en pacientes críticos. La asincronía paciente-ventilador existe cuando las fases de la respiración administradas por el ventilador no coinciden con las del paciente. Las asincronías son frecuentes e infradiagnosticadas, éstas se han asociado con desenlaces desfavorables como son: mayor duración de ventilación mecánica, estancia en la unidad de terapia intensiva, mortalidad, incomodidad del paciente, alteraciones del sueño y disfunción diafragmática. Esta revisión describe los desenlaces adversos reportados que se han asociado a la presencia de asincronías en pacientes adultos bajo ventilación mecánica invasiva. La evidencia actual sugiere que el mejor enfoque para manejar las asincronías es ajustar la configuración del ventilador y mejorar su detección. Si bien la mayoría de la evidencia proviene de estudios observacionales y ensayos clínicos aleatorizados realizados en poblaciones heterogéneas y con un número limitado de pacientes, los resultados sugieren desenlaces desfavorables clínicamente significativos en los pacientes que experimentan un índice de asincronía elevado. Por lo anterior, es necesario generar mayor evidencia en este tópico.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: Mechanical ventilation is common in critically ill patients. Patient-ventilator asynchrony exists when the breathing phases administered by the ventilator do not match those of the patient. They are frequent but underdiagnosed, and have been associated with worse outcomes because they negatively affect patient comfort, length of mechanical ventilation, length of stay in the intensive care unit and mortality. This review describes the negative outcomes associated with the presence of asynchronies in adult patients with invasive mechanical ventilation. Current evidence suggests that the best approach to handle asynchronies is to adjust the fan settings and improve the quality of detection. While most of this evidence comes from observational studies and randomized clinical trials which were done with heterogeneous populations and a limited number of patients, the results suggest less favorable clinically significant outcomes in patients with asynchronies. So it is necessary to generate more evidence in this topic.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo: A ventilação mecânica é comum em pacientes críticos. A assincronia paciente-ventilador existe quando as fases da respiração fornecida pelo ventilador não coincidem com as do paciente. As assincronas são frequentes e subdiagnosticadas, tendo sido associadas a desfechos desfavoráveis como: maior tempo de ventilação mecânica, permanência em unidade de terapia intensiva, mortalidade, desconforto do paciente, distúrbios do sono e disfunção diafragmática. Esta revisão descreve os resultados adversos relatados que foram associados à presença de assincronia em pacientes adultos sob ventilação mecânica invasiva. A evidência atual sugere que a melhor abordagem para gerenciar assincronias é ajustar as configurações do ventilador e melhorar a detecção do ventilador. Embora a maioria das evidências provenha de estudos observacionais e ensaios clínicos randomizados conduzidos em populações heterogêneas e com um número limitado de pacientes, os resultados sugerem resultados clinicamente desfavoráveis significativos em pacientes que apresentam uma alta taxa de assincronia. Portanto, é necessário gerar mais evidências sobre este tema.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Asincronía]]></kwd>
<kwd lng="es"><![CDATA[mortalidad]]></kwd>
<kwd lng="es"><![CDATA[ventilación mecánica]]></kwd>
<kwd lng="es"><![CDATA[interacción paciente-ventilador]]></kwd>
<kwd lng="en"><![CDATA[Asynchrony]]></kwd>
<kwd lng="en"><![CDATA[mortality]]></kwd>
<kwd lng="en"><![CDATA[mechanical ventilation]]></kwd>
<kwd lng="en"><![CDATA[patient-ventilator interaction]]></kwd>
<kwd lng="pt"><![CDATA[Assincronia]]></kwd>
<kwd lng="pt"><![CDATA[mortalidade]]></kwd>
<kwd lng="pt"><![CDATA[ventilação mecânica]]></kwd>
<kwd lng="pt"><![CDATA[interação paciente-ventilador]]></kwd>
</kwd-group>
</article-meta>
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