<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2448-8909</journal-id>
<journal-title><![CDATA[Medicina crítica (Colegio Mexicano de Medicina Crítica)]]></journal-title>
<abbrev-journal-title><![CDATA[Med. crít. (Col. Mex. Med. Crít.)]]></abbrev-journal-title>
<issn>2448-8909</issn>
<publisher>
<publisher-name><![CDATA[Colegio Mexicano de Medicina Crítica A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2448-89092020000200156</article-id>
<article-id pub-id-type="doi">10.35366/93970</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Trampas extracelulares de neutrófilos en sepsis]]></article-title>
<article-title xml:lang="en"><![CDATA[Neutrophil extracellular traps in sepsis]]></article-title>
<article-title xml:lang="pt"><![CDATA[Armadilhas extracelulares de neutrófilos na sepse]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Godínez Vidal]]></surname>
<given-names><![CDATA[Ansony Roger]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Carrillo Esper]]></surname>
<given-names><![CDATA[Raúl]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cabello Aguilera]]></surname>
<given-names><![CDATA[Ricardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,HMG Hospital Coyoacán  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2020</year>
</pub-date>
<volume>34</volume>
<numero>2</numero>
<fpage>156</fpage>
<lpage>159</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2448-89092020000200156&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2448-89092020000200156&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2448-89092020000200156&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen:  Introducción:  Los neutrófilos son uno de los componentes celulares más importantes de la inmunidad innata, debido a que estas células se reclutan rápidamente a los sitios de infección y pueden eliminar patógenos por múltiples métodos. En diferentes entidades, de entre las que se destaca la sepsis, los neutrófilos mejoran sus propiedades antimicrobianas mediante la liberación de trampas extracelulares de neutrófilos (TEN), constituidas por cromatina, histonas y proteínas granulares, proceso que es conocido por NETosis.  Objetivo:  El objetivo de esta revisión es examinar los conceptos actuales, relacionados con los mecanismos subyacentes de la formación de TEN y su impacto en sepsis.  Conclusión:  La desregulación de la NETosis causada por sepsis puede tener efectos deletéreos en sepsis, destacando inflamación, trombosis y disfunción multiorgánica.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract:  Introduction:  Neutrophils are one of the most important cellular components of innate immunity because these cells are rapidly recruited to sites of infection and can eliminate pathogens by multiple methods. In different entities from which sepsis disables neutrophils improve their antimicrobial properties by releasing neutrophils extracellular traps (NET), constituted by chromatin, histones and granular proteins, a process that is known by NETosis.  Objective:  The objective of this paper is to review current concepts related to the underlying mechanisms of the formation of NETs, as well as the beneficial and harmful effects of them.  Conclusions:  The dysregulation of NETosis caused by sepsis can have detrimental effects that cause inflammation, thrombosis and multi-organ failure.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo:  Introdução:  Os neutrófilos são um dos componentes celulares mais importantes da imunidade inata, porque essas células se recrutam rapidamente para locais de infecção e podem matar patógenos por vários métodos. Em diferentes entidades das quais se destaca a sepse, os neutrófilos melhoram suas propriedades antimicrobianas liberando as armadilhas extracelulares de neutrófilos (del inglés: neutrophil extracelular traps, NET), compostas por cromatina, histonas e proteínas granulares, um processo conhecido como NETosis.  Objetivo:  O objetivo desta revisão é revisar os conceitos atuais relacionados aos mecanismos subjacentes à formação das NET e seu impacto na sepse.  Conclusão:  A desregulação da NETosis causada pela sepse pode ter efeitos deletérios na sepse, destacando inflamação, trombose e disfunção de múltiplos órgãos.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Neutrófilos]]></kwd>
<kwd lng="es"><![CDATA[infección]]></kwd>
<kwd lng="es"><![CDATA[cromatina]]></kwd>
<kwd lng="es"><![CDATA[histonas]]></kwd>
<kwd lng="es"><![CDATA[sepsis]]></kwd>
<kwd lng="es"><![CDATA[inflamación]]></kwd>
<kwd lng="en"><![CDATA[Neutrophils]]></kwd>
<kwd lng="en"><![CDATA[infection]]></kwd>
<kwd lng="en"><![CDATA[chromatin]]></kwd>
<kwd lng="en"><![CDATA[histones]]></kwd>
<kwd lng="en"><![CDATA[sepsis]]></kwd>
<kwd lng="en"><![CDATA[inflammation]]></kwd>
<kwd lng="pt"><![CDATA[Neutrófilos]]></kwd>
<kwd lng="pt"><![CDATA[infecção]]></kwd>
<kwd lng="pt"><![CDATA[cromatina]]></kwd>
<kwd lng="pt"><![CDATA[histonas]]></kwd>
<kwd lng="pt"><![CDATA[sepse]]></kwd>
<kwd lng="pt"><![CDATA[inflamação]]></kwd>
</kwd-group>
</article-meta>
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