<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2448-8909</journal-id>
<journal-title><![CDATA[Medicina crítica (Colegio Mexicano de Medicina Crítica)]]></journal-title>
<abbrev-journal-title><![CDATA[Med. crít. (Col. Mex. Med. Crít.)]]></abbrev-journal-title>
<issn>2448-8909</issn>
<publisher>
<publisher-name><![CDATA[Colegio Mexicano de Medicina Crítica A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2448-89092019000600298</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Aclaramiento del déficit de base estándar como pronóstico de mortalidad en choque séptico]]></article-title>
<article-title xml:lang="en"><![CDATA[Standard base deficit clearance as prognostic factor of mortality in septic shock]]></article-title>
<article-title xml:lang="pt"><![CDATA[Depuração do déficit de base padrão como prognóstico de morte no choque séptico]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García Gómez]]></surname>
<given-names><![CDATA[Gabriel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sánchez Díaz]]></surname>
<given-names><![CDATA[Jesús Salvador]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Peniche Moguel]]></surname>
<given-names><![CDATA[Karla Gabriela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Monares Zepeda]]></surname>
<given-names><![CDATA[Enrique]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martínez Rodríguez]]></surname>
<given-names><![CDATA[Enrique Antonio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Calyeca Sánchez]]></surname>
<given-names><![CDATA[María Verónica]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Mexicano del Seguro Social Centro Médico Nacional «Adolfo Ruiz Cortines» Hospital de Especialidades Núm. 14]]></institution>
<addr-line><![CDATA[Veracruz Veracruz]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital San Ángel Inn Universidad  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Centro Médico ABC  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2019</year>
</pub-date>
<volume>33</volume>
<numero>6</numero>
<fpage>298</fpage>
<lpage>304</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2448-89092019000600298&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2448-89092019000600298&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2448-89092019000600298&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen:  Introducción:  A finales de la década de los cincuenta, el concepto de exceso de base (EB) fue introducido por Siggaard-Andersen como marcador sérico de los problemas estrictamente metabólicos. Hoy en día, la base (B) ha sido estandarizada con resultados más efectivos cuando utilizamos la base estándar (Becf) en la evaluación clínica. El lactato y la base estándar medidos al ingresar a la Unidad de Cuidados Intensivos (UCI) son de utilidad pronóstica en los pacientes críticamente enfermos. Decidimos medir el aclaramiento del déficit de base estándar en los pacientes con choque séptico en las 24 horas subsecuentes a partir del ingreso y evaluar su utilidad pronóstica para la mortalidad.  Material y métodos:  Estudio de cohorte, retrospectivo, descriptivo y analítico, que incluyó pacientes con diagnóstico de choque séptico según el tercer Consenso Internacional de Sepsis y Choque Séptico (sepsis-3) ingresados a la Unidad de Cuidados Intensivos (UCI) durante el periodo comprendido de mayo de 2015 a mayo de 2019. Los pacientes se asignaron al grupo &lt; 11% o al grupo &#8805; 11% según su porcentaje (%) de aclaramiento de déficit de base estándar a las 24 horas.  Resultados:  Se incluyeron 118 pacientes que cumplieron con los criterios de inclusión. Del total, 43 pacientes se asignaron al grupo de aclaramiento de déficit de base estándar &lt; 11% y 75 pacientes al grupo de aclaramiento de déficit de base estándar &#8805; 11%. En el grupo con aclaramiento &lt; 11%, la mortalidad fue de 65.1% y de 36% para el grupo con aclaramiento &#8805; 11% con p = &lt; 0.05.  Conclusión:  El aclaramiento del déficit de base estándar &lt; 11% a las 24 horas de ingreso a la Unidad de Cuidados Intensivos incrementa el riesgo de muerte en el choque séptico. El porcentaje de aclaramiento del déficit de base estándar es una excelente alternativa, pues su desempeño para predecir la mortalidad tiene una capacidad pronóstica similar a la del lactato.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract:  Introduction:  The concept of base excess (BE) was introduced by Siggaard-Andersen in the late 1950s as a serum marker of strictly metabolic problems. Today the base (B) has been standardized with more effective results when we use the standard base (ecfB) in the clinical evaluation. Lactate and the standard base measured upon admission to the Intensive Care Unit (ICU) are of prognostic utility in critically ill patients. We decided to measure the standard base deficit clearance at 24 hours after admission in patients with septic shock and evaluate its prognostic utility for mortality.  Material and methods:  Cohort, retrospective, descriptive, analytical study that included patients with diagnosis of septic shock according to the third international consensus of sepsis and septic shock (sepsis-3) admitted to the ICU in the period from May 2015 to May 2019. Patients were assigned to belong to group &lt; 11% or group &#8805; 11% according to their percentage (%) of standard base deficit clearance at 24 hours.  Results:  118 patients who met the inclusion criteria were included. Of the total, 43 patients were assigned to the standard base deficit clearance group &lt; 11% and 75 patients to the standard base deficit clearance group &#8805; 11%. In the group with clearance &lt; 11% the mortality was 65.1 and 36% for the group with clearance &#8805; 11% with p = &lt; 0.05.  Conclusion:  Clearance the standard base deficit &lt; 11% after 24 hours of admission to the ICU increases the risk of death in septic shock. The percentage of standard base deficit clearance is an excellent alternative, since its performance to predict mortality has a prognostic capacity similar to that of lactate.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo:  Introdução:  O conceito de excesso de base (EB) foi introduzido por Siggaard-Andersen no final da década de 1950 como um marcador sérico de problemas estritamente metabólicos. Hoje a base (B) foi padronizada com resultados mais eficazes quando usamos a base padrão (Becf) na avaliação clínica. O lactato e a base padrão medidas na admissão na unidade de terapia intensiva (UTI) são de utilidade prognóstica em pacientes críticos. Decidimos medir a depuração do déficit de base padrão 24 horas após a internação em pacientes com choque séptico e avaliar sua utilidade prognóstica para a mortalidade.  Material e métodos:  Estudo de coorte, retrospectivo, descritivo, analítico que incluiu pacientes com diagnóstico de choque séptico de acordo com o terceiro consenso internacional de sepse e choque séptico (sepse-3) admitidos na UTI no período de maio de 2015 a maio de 2019. Os pacientes foram designados para pertencer ao grupo &lt; 11% ou grupo &#8805; 11%, de acordo com a porcentagem (%) de depuração do déficit de base às 24 horas.  Resultados:  Foram incluídos 118 pacientes que atenderam aos critérios de inclusão. Do total, 43 pacientes foram designados para o grupo de depuração do déficit de base padrão &lt; 11% e 75 pacientes para o grupo de depuração do déficit de base padrão &#8805; 11%. No grupo com depuração &lt; 11% a mortalidade foi de 65.1% e 36% no grupo com depuração &#8805; 11% com p = &lt; 0.05.  Conclusão:  A depuração do déficit de base padrão &lt; 11% após 24 horas de internação na UTI aumenta o risco de morte em choque séptico. A porcentagem de depuração do déficit de base padrão é uma excelente alternativa, uma vez que seu desempenho na predição da mortalidade possui capacidade prognóstica semelhante à do lactato.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Choque séptico]]></kwd>
<kwd lng="es"><![CDATA[aclaramiento del déficit de base estándar]]></kwd>
<kwd lng="es"><![CDATA[mortalidad]]></kwd>
<kwd lng="en"><![CDATA[Septic shock]]></kwd>
<kwd lng="en"><![CDATA[standard base deficit clearance]]></kwd>
<kwd lng="en"><![CDATA[mortality]]></kwd>
<kwd lng="pt"><![CDATA[Choque séptico]]></kwd>
<kwd lng="pt"><![CDATA[depuração do déficit de base padrão]]></kwd>
<kwd lng="pt"><![CDATA[mortalidade]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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