<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2448-8909</journal-id>
<journal-title><![CDATA[Medicina crítica (Colegio Mexicano de Medicina Crítica)]]></journal-title>
<abbrev-journal-title><![CDATA[Med. crít. (Col. Mex. Med. Crít.)]]></abbrev-journal-title>
<issn>2448-8909</issn>
<publisher>
<publisher-name><![CDATA[Colegio Mexicano de Medicina Crítica A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2448-89092019000400182</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Origen de la acidosis metabólica según los determinantes del déficit de base en pacientes con choque séptico como factor de riesgo para mortalidad]]></article-title>
<article-title xml:lang="en"><![CDATA[Origin of metabolic acidosis according to the determinants of the base deficit in patients with septic shock as a risk factor for mortality]]></article-title>
<article-title xml:lang="pt"><![CDATA[Origem da acidose metabólica de acordo com os determinantes do déficit de base em pacientes com choque septico como fator de risco para a mortalidade]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Márquez Rosales]]></surname>
<given-names><![CDATA[Eduardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sánchez Díaz]]></surname>
<given-names><![CDATA[Jesús Salvador]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Peniche Moguel]]></surname>
<given-names><![CDATA[Karla Gabriela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martínez Rodríguez]]></surname>
<given-names><![CDATA[Enrique Antonio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Villegas Domínguez]]></surname>
<given-names><![CDATA[Josué Eli]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Calyeca Sánchez]]></surname>
<given-names><![CDATA[María Verónica]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Mexicano del Seguro Social Hospital de Especialidades Núm. 14 Unidad Médica de Alta Especialidad 189]]></institution>
<addr-line><![CDATA[Veracruz ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Centro Médico ABC  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad del Valle de México Facultad de Medicina ]]></institution>
<addr-line><![CDATA[Veracruz ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2019</year>
</pub-date>
<volume>33</volume>
<numero>4</numero>
<fpage>182</fpage>
<lpage>188</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2448-89092019000400182&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2448-89092019000400182&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2448-89092019000400182&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen:  Introducción:  En los pacientes con choque séptico la acidosis metabólica es el trastorno ácido-base más frecuente, y el principal ion causante determinará el pronóstico en este grupo. Los estudios se han centrado en la estimación de lactato para determinar el pronóstico, aunque hoy en día sabemos que la acidosis metabólica en estos puede estar causada por el efecto, no sólo del lactato, sino también por el efecto del agua, del cloro, de la albúmina y de los aniones no medidos.  Material y métodos:  Se realizó un estudio de cohorte, ambispectivo, longitudinal, descriptivo y analítico. En aquéllos con diagnóstico de choque séptico y acidosis metabólica, ingresados a la Unidad de Cuidados Intensivos (UCI) en el periodo comprendido del 15 de junio del 2015 al 30 de julio del 2018. Se evaluó el riesgo para mortalidad de las variables: lactato, el efecto del agua, del cloro, de la albúmina y de los aniones no medidos. Todos los análisis estadísticos se realizaron con el programa SPSSTM 22.0.  Resultados: En el periodo considerado, 87 cumplieron con los criterios de inclusión, de los cuales 46% fueron hombres y 54% mujeres. De éstos, 44.8% fallecieron durante su estancia. En el análisis multivariado, las variables con relevancia estadística, medidas al ingreso como factor de riesgo para mortalidad fueron: el efecto del agua con punto de corte &gt; -0.75 mEq/L, presenta un OR 7.227 (IC95%: 1.831-28.5; p = 0.005), el efecto de la albúmina con punto de corte de &gt; -4.75 mEq/L, presenta un OR 6.163 (IC95%: 1.786-21.2; p = 0.004).  Conclusión:  La acidosis metabólica va más allá de la adición o remoción de solutos, teniendo gran importancia la disociación del agua.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract:  Introduction:  In patients with septic shock, metabolic acidosis is the most frequent acid-base disorder and the main causative ion will determine the prognosis in this group of patients. Studies have focused on the estimation of lactate to determine the prognosis, although today we know that metabolic acidosis in these patients may be caused by the effect not only of lactate but also by the effect of water, effect of chlorine, effect of albumin and effect of unmeasured anions.  Material and methods:  A cohort study was performed, ambispective, longitudinal, descriptive and analytical. In patients diagnosed with septic shock and metabolic acidosis, admitted to the Intensive Care Unit (ICU) in the period from June 15, 2015 to July 30, 2018. The risk for mortality of the variables was evaluated: lactate, the effect of water, the effect of chlorine, the effect of albumin and the effect of unmeasured anions. All statistical analyzes were performed with the SPSSTM 22.0 program.  Results:  In the period considered, 87 patients met the inclusion criteria, of which 46% were male and 54% were female. 44.8% of patients died during their stay. In the multivariate analysis, the variables with statistical significance, measures at admission as a risk factor for mortality were: the effect of water with cut-off point &gt; -0.75 mEq/L, presents an OR 7.227 (CI95%: 1.831-28.5; p = 0.005), the effect of albumin with cut-off point of &gt; -4.75 mEq/L, presents an OR 6.163 (CI95%: 1.786-21.2, p = 0.004).  Conclusion:  Metabolic acidosis goes beyond the addition or removal of solutes, the dissociation of water having great importance.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo:  Introdução:  Em pacientes com choque séptico a acidose metabólica é o distúrbio ácido-base mais frequente e o principal íon causador determinará o prognóstico nesse grupo de pacientes. Os estudos têm focado na estimativa do lactato para determinar o prognóstico, embora hoje sabemos que a acidose metabólica nesses pacientes pode ser causada pelo efeito não só do lactato, mas também pelo efeito da água, do cloro, da albumina e efeito dos ânions não medidos.  Material e métodos:  Foi realizado um estudo de coorte, ambispectivo, longitudinal, descritivo e analítico em pacientes com diagnóstico de choque séptico e acidose metabólica, internados na Unidade de Terapia Intensiva (UTI) no período de 15 de junho de 2015 a 30 de julho de 2018. Avaliou-se o risco de mortalidade das variáveis: lactato, efeito da água, do cloro, da albumina e efeito de ânions não medidos. Todas as análises estatísticas foram realizadas com o programa SPSS v22.0.  Resultados:  No período considerado, 87 pacientes preencheram os critérios de inclusão, dos quais 46% eram do sexo masculino e 54% do sexo feminino. 44.8% dos pacientes morreram durante a internação. Na análise multivariada, as variáveis com relevância estatística medidas no momento da internação como fator de risco para mortalidade foram: o efeito da água com ponto de corte &gt; -0.75 mEq/L, apresentou um OR 7.227 (IC95%: 1.831-28.5; p = 0.005), o efeito da albumina com um ponto de corte &gt; -4.75 mEq/L, apresentou um OR 6.163 (CI95%: 1.786-21.2; p = 0.004).  Conclusão:  A acidose metabólica vai além da adição ou remoção de solutos, sendo a dissociação da água de grande importância.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Choque séptico]]></kwd>
<kwd lng="es"><![CDATA[acidosis metabólica]]></kwd>
<kwd lng="es"><![CDATA[mortalidad]]></kwd>
<kwd lng="en"><![CDATA[Septic shock]]></kwd>
<kwd lng="en"><![CDATA[metabolic acidosis]]></kwd>
<kwd lng="en"><![CDATA[mortality]]></kwd>
<kwd lng="pt"><![CDATA[Choque séptico]]></kwd>
<kwd lng="pt"><![CDATA[acidose metabólica]]></kwd>
<kwd lng="pt"><![CDATA[mortalidade]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Al-Jaghbeer]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Kellum]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Acid-base disturbances in intensive care patients: etiology, pathophysiology and treatment]]></article-title>
<source><![CDATA[Nephrol Dial Transplant]]></source>
<year>2014</year>
<volume>30</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>1104-11</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kishen]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Honoré]]></surname>
<given-names><![CDATA[PM]]></given-names>
</name>
<name>
<surname><![CDATA[Jacobs]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Joannes-Boyau]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[De Waele]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[De Regt]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Facing acid-base disorders in the third millennium-the Stewart approach revisited]]></article-title>
<source><![CDATA[Int J Nephrol Renovasc Dis]]></source>
<year>2014</year>
<volume>7</volume>
<page-range>209-17</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sánchez-Díaz]]></surname>
<given-names><![CDATA[JS]]></given-names>
</name>
<name>
<surname><![CDATA[Martínez-Rodríguez]]></surname>
<given-names><![CDATA[EA]]></given-names>
</name>
<name>
<surname><![CDATA[Méndez-Rubio]]></surname>
<given-names><![CDATA[LP]]></given-names>
</name>
<name>
<surname><![CDATA[Peniche-Moguel]]></surname>
<given-names><![CDATA[KG]]></given-names>
</name>
<name>
<surname><![CDATA[Huanca-Pacaje]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
<name>
<surname><![CDATA[López-Guzmán]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Equilibrio ácido-base. Puesta al día. Teoría de Henderson-Hasselbalch]]></article-title>
<source><![CDATA[Med Int Mex]]></source>
<year>2016</year>
<volume>32</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>646-60</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gunnerson]]></surname>
<given-names><![CDATA[KJ]]></given-names>
</name>
<name>
<surname><![CDATA[Saul]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[He]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Kellum]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Lactate versus non-lactate metabolic acidosis: a retrospective outcome evaluation of critically ill patients]]></article-title>
<source><![CDATA[Crit Care]]></source>
<year>2006</year>
<volume>10</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>R22</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gunnerson]]></surname>
<given-names><![CDATA[KJ]]></given-names>
</name>
<name>
<surname><![CDATA[Saul]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Kellum]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Lactic versus non-lactic metabolic acidosis: outcomes in critically ill patients]]></article-title>
<source><![CDATA[Crit Care]]></source>
<year>2003</year>
<volume>7</volume>
<numero>^s2</numero>
<issue>^s2</issue>
<supplement>2</supplement>
<page-range>P017</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kruse]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Grunnet]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Barfod]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Blood lactate as a predictor for in-hospital mortality in patients admitted acutely to hospital: a systematic review]]></article-title>
<source><![CDATA[Scand J Trauma Resusc Emerg Med]]></source>
<year>2011</year>
<volume>19</volume>
<page-range>74</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Magder]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Emami]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Practical approach to physical-chemical acid-base management. Stewart at the bedside]]></article-title>
<source><![CDATA[Ann Am Thorac Soc]]></source>
<year>2015</year>
<volume>12</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>111-7</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Adrogué]]></surname>
<given-names><![CDATA[HJ]]></given-names>
</name>
<name>
<surname><![CDATA[Gennari]]></surname>
<given-names><![CDATA[FJ]]></given-names>
</name>
<name>
<surname><![CDATA[Galla]]></surname>
<given-names><![CDATA[JH]]></given-names>
</name>
<name>
<surname><![CDATA[Madias]]></surname>
<given-names><![CDATA[NE]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Assessing acid-base disorders]]></article-title>
<source><![CDATA[Kidney Int]]></source>
<year>2009</year>
<volume>76</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>1239-47</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Berend]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[de Vries]]></surname>
<given-names><![CDATA[AP]]></given-names>
</name>
<name>
<surname><![CDATA[Gans]]></surname>
<given-names><![CDATA[RO]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Physiological approach to assessment of acid-base disturbances]]></article-title>
<source><![CDATA[N Engl J Med]]></source>
<year>2014</year>
<volume>371</volume>
<numero>15</numero>
<issue>15</issue>
<page-range>1434-45</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sánchez]]></surname>
<given-names><![CDATA[DJ]]></given-names>
</name>
<name>
<surname><![CDATA[Monares]]></surname>
<given-names><![CDATA[ZE]]></given-names>
</name>
<name>
<surname><![CDATA[Meneses]]></surname>
<given-names><![CDATA[OC]]></given-names>
</name>
<name>
<surname><![CDATA[Rodríguez]]></surname>
<given-names><![CDATA[ME]]></given-names>
</name>
<name>
<surname><![CDATA[García]]></surname>
<given-names><![CDATA[MR]]></given-names>
</name>
<name>
<surname><![CDATA[Peniche]]></surname>
<given-names><![CDATA[MK]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Soluciones balanceadas: cloro el &#8220;nuevo villano&#8221;]]></article-title>
<source><![CDATA[Med Crit]]></source>
<year>2017</year>
<volume>31</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>152-8</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Emmett]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Narins]]></surname>
<given-names><![CDATA[RG]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Clinical use of the anion gap]]></article-title>
<source><![CDATA[Medicine (Baltimore)]]></source>
<year>1977</year>
<volume>56</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>38-54</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Andersen]]></surname>
<given-names><![CDATA[OS]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The pH-log pCO2 blood acid-base nomogram revised]]></article-title>
<source><![CDATA[Scand J Clin Lab Invest]]></source>
<year>1962</year>
<volume>14</volume>
<page-range>598-604</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Dimeski]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Badrick]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[John]]></surname>
<given-names><![CDATA[AS]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Ion selective electrodes (ISEs) and interferences-a review]]></article-title>
<source><![CDATA[Clin Chim Acta]]></source>
<year>2010</year>
<volume>411</volume>
<numero>5-6</numero>
<issue>5-6</issue>
<page-range>309-17</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Berend]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[van Hulsteijn]]></surname>
<given-names><![CDATA[LH]]></given-names>
</name>
<name>
<surname><![CDATA[Gans]]></surname>
<given-names><![CDATA[RO]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Chloride: the queen of electrolytes?]]></article-title>
<source><![CDATA[Eur J Intern Med]]></source>
<year>2012</year>
<volume>23</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>203-11</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Figge]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Mydosh]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Fencl]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Serum proteins and acid-base equilibria: a follow-up]]></article-title>
<source><![CDATA[J Lab Clin Med]]></source>
<year>1992</year>
<volume>120</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>713-9</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Dubin]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Menises]]></surname>
<given-names><![CDATA[MM]]></given-names>
</name>
<name>
<surname><![CDATA[Masevicius]]></surname>
<given-names><![CDATA[FD]]></given-names>
</name>
<name>
<surname><![CDATA[Moseinco]]></surname>
<given-names><![CDATA[MC]]></given-names>
</name>
<name>
<surname><![CDATA[Kutscherauer]]></surname>
<given-names><![CDATA[DO]]></given-names>
</name>
<name>
<surname><![CDATA[Ventrice]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Comparison of three different methods of evaluation of metabolic acid-base disorders]]></article-title>
<source><![CDATA[Crit Care Med]]></source>
<year>2007</year>
<volume>35</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>1264-70</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kellum]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Elbers]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<source><![CDATA[Stewart&#8217;s textbook of acid-base]]></source>
<year>2009</year>
<edition>2</edition>
<publisher-loc><![CDATA[Amsterdam, NE ]]></publisher-loc>
<publisher-name><![CDATA[AcidBase.org]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Guggenheim]]></surname>
<given-names><![CDATA[EA]]></given-names>
</name>
</person-group>
<source><![CDATA[Thermodynamics, an advanced treatment for chemists and physicist]]></source>
<year>1957</year>
<page-range>372</page-range><publisher-loc><![CDATA[Amsterdam ]]></publisher-loc>
<publisher-name><![CDATA[Noth Holland Publishing Company]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kellum]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Determinants of plasma acid-base balance]]></article-title>
<source><![CDATA[Crit Care Clin]]></source>
<year>2005</year>
<volume>21</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>329-46</page-range></nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sánchez]]></surname>
<given-names><![CDATA[DJ]]></given-names>
</name>
<name>
<surname><![CDATA[Peniche]]></surname>
<given-names><![CDATA[MK]]></given-names>
</name>
<name>
<surname><![CDATA[Martínez]]></surname>
<given-names><![CDATA[RE]]></given-names>
</name>
<name>
<surname><![CDATA[Cortés]]></surname>
<given-names><![CDATA[RJ]]></given-names>
</name>
<name>
<surname><![CDATA[Rivera]]></surname>
<given-names><![CDATA[SG]]></given-names>
</name>
<name>
<surname><![CDATA[Díaz]]></surname>
<given-names><![CDATA[GS]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Falsas creencias de los trastornos ácido-base]]></article-title>
<source><![CDATA[Acta Colomb Cuid Intensivo]]></source>
<year>2018</year>
<volume>18</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>243-50</page-range></nlm-citation>
</ref>
<ref id="B21">
<label>21</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Noritomi]]></surname>
<given-names><![CDATA[DT]]></given-names>
</name>
<name>
<surname><![CDATA[Soriano]]></surname>
<given-names><![CDATA[FG]]></given-names>
</name>
<name>
<surname><![CDATA[Kellum]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Cappi]]></surname>
<given-names><![CDATA[SB]]></given-names>
</name>
<name>
<surname><![CDATA[Biselli]]></surname>
<given-names><![CDATA[PJ]]></given-names>
</name>
<name>
<surname><![CDATA[Liborio]]></surname>
<given-names><![CDATA[AB]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Metabolic acidosis in patients with severe sepsis and septic shock: a longitudinal quantitative study]]></article-title>
<source><![CDATA[Crit Care Med]]></source>
<year>2009</year>
<volume>37</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>2733-9</page-range></nlm-citation>
</ref>
<ref id="B22">
<label>22</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Smith]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Kumar]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Molloy]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Rhodes]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Newman]]></surname>
<given-names><![CDATA[PJ]]></given-names>
</name>
<name>
<surname><![CDATA[Grounds]]></surname>
<given-names><![CDATA[RM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Base excess and lactate as prognostic indicators for patients admitted to intensive care]]></article-title>
<source><![CDATA[Intensive Care Med]]></source>
<year>2001</year>
<volume>27</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>74-83</page-range></nlm-citation>
</ref>
<ref id="B23">
<label>23</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Stewart]]></surname>
<given-names><![CDATA[PA]]></given-names>
</name>
</person-group>
<source><![CDATA[How to understand acid-base: a quantitative acid-base primer for biology and medicine]]></source>
<year>1981</year>
<publisher-loc><![CDATA[New York, NY ]]></publisher-loc>
<publisher-name><![CDATA[Elsevier]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B24">
<label>24</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gunnerson]]></surname>
<given-names><![CDATA[KJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Clinical review: The meaning of acid-base abnormalities in the intensive care unit part I - epidemiology]]></article-title>
<source><![CDATA[Crit Care]]></source>
<year>2005</year>
<volume>9</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>508-16</page-range></nlm-citation>
</ref>
<ref id="B25">
<label>25</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kishen]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Honoré]]></surname>
<given-names><![CDATA[PM]]></given-names>
</name>
<name>
<surname><![CDATA[Jacobs]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Joannes-Boyau]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[De Waele]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[De Regt]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Facing acid-base disorders in the third millennium - the Stewart approach revisited]]></article-title>
<source><![CDATA[Int J Nephrol Renovasc Dis]]></source>
<year>2014</year>
<volume>7</volume>
<page-range>209-17.26</page-range></nlm-citation>
</ref>
<ref id="B26">
<label>26</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Meza]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Disturbios del estado ácido-básico en el paciente crítico]]></article-title>
<source><![CDATA[Acta Med Per]]></source>
<year>2011</year>
<volume>28</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>46-58</page-range></nlm-citation>
</ref>
<ref id="B27">
<label>27</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Masevicius]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Dubin]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Has Stewart approach improved our ability to diagnose acid-base disorders in critically ill patients]]></article-title>
<source><![CDATA[World J Crit Care Med]]></source>
<year>2001</year>
<volume>4</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>62-70</page-range></nlm-citation>
</ref>
<ref id="B28">
<label>28</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cortés-Román]]></surname>
<given-names><![CDATA[JS]]></given-names>
</name>
<name>
<surname><![CDATA[Sánchez-Díaz]]></surname>
<given-names><![CDATA[JS]]></given-names>
</name>
<name>
<surname><![CDATA[García-Méndez]]></surname>
<given-names><![CDATA[RC]]></given-names>
</name>
<name>
<surname><![CDATA[Martínez-Rodríguez]]></surname>
<given-names><![CDATA[EA]]></given-names>
</name>
<name>
<surname><![CDATA[Peniche-Moguel]]></surname>
<given-names><![CDATA[KG]]></given-names>
</name>
<name>
<surname><![CDATA[Díaz-Gutiérrez]]></surname>
<given-names><![CDATA[SP]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Diferencia sodio-cloro e índice cloro/sodio como predictores de mortalidad en choque séptico]]></article-title>
<source><![CDATA[Med Int Méx]]></source>
<year>2017</year>
<volume>33</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>335-43</page-range></nlm-citation>
</ref>
<ref id="B29">
<label>29</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kraut]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Nagami]]></surname>
<given-names><![CDATA[GT]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The serum anion gap in the evaluation of acid-base disorders: what are its limitations and can its effectiveness be improved?]]></article-title>
<source><![CDATA[Clin J Am Soc Nephrol]]></source>
<year>2013</year>
<volume>8</volume>
<numero>11</numero>
<issue>11</issue>
<page-range>2018-24</page-range></nlm-citation>
</ref>
<ref id="B30">
<label>30</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Feldman]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Soni]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Dickson]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Influence of hypoalbuminemia or hyperalbuminemia on the serum anion gap]]></article-title>
<source><![CDATA[J Lab Clin Med]]></source>
<year>2005</year>
<volume>146</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>317-20</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
