<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2448-8909</journal-id>
<journal-title><![CDATA[Medicina crítica (Colegio Mexicano de Medicina Crítica)]]></journal-title>
<abbrev-journal-title><![CDATA[Med. crít. (Col. Mex. Med. Crít.)]]></abbrev-journal-title>
<issn>2448-8909</issn>
<publisher>
<publisher-name><![CDATA[Colegio Mexicano de Medicina Crítica A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2448-89092019000200084</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Eficiencia diagnóstica de la procalcitonina en sepsis y choque séptico en pacientes ingresados a la terapia intensiva]]></article-title>
<article-title xml:lang="en"><![CDATA[Diagnostic efficiency of procalcitonin in sepsis and septic shock in patients admitted to intensive care unit]]></article-title>
<article-title xml:lang="pt"><![CDATA[Eficiência diagnóstica da procalcitonina em sepse e choque séptico em pacientes admitidos à terapia intensiva]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Visoso Palacios]]></surname>
<given-names><![CDATA[Porfirio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Izaguirre Gutiérrez]]></surname>
<given-names><![CDATA[Victor Francisco]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Central Sur de Alta Especialidad Petróleos Mexicanos  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2019</year>
</pub-date>
<volume>33</volume>
<numero>2</numero>
<fpage>84</fpage>
<lpage>90</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2448-89092019000200084&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2448-89092019000200084&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2448-89092019000200084&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen:  Introducción:  La sepsis y el choque séptico son la principal causa de ingreso a las unidades de cuidados intensivos, en el mundo se estima que 20-30 millones de casos de sepsis suceden al año. De estos casos, entre una tercera parte y la mitad fallecen.  Objetivo:  El objetivo de este estudio fue evaluar la eficiencia diagnóstica de procalcitonina en sepsis y choque séptico.  Material y métodos:  Se realizó un estudio observacional analítico, prospectivo, longitudinal, en el periodo comprendido entre el 1o de septiembre de 2017 al 31 de mayo de 2018, en la Unidad de Terapia Intensiva (UTI). A todos los pacientes se les tomó procalcitonina durante su ingreso, y se realizó una clasificación de acuerdo con los criterios de sepsis o choque séptico del SEPSIS-3, así como la eficiencia diagnóstica de estos biomarcadores.  Resultados:  Ingresaron 171 pacientes a la UTI en este periodo; diagnóstico de ingreso: 63 (40.9%) ingresaron con sepsis y de ellos, 36 (57.1%) con choque séptico, 91 (59.1%) con otros diagnósticos; el APACHE II, quick-SOFA y SOFA 12.83 (± 7.92), 1.11 (± 0.92), 4.64 (± 3.03) en los controles vs 22.45 (± 7.24), 2.14 (± 0.83), 8.18 (± 3.50) en los pacientes con sepsis o choque séptico, los tres con p valor de &lt; 0.001. En cuanto a la determinación de procalcitonina en controles vs pacientes con sepsis/choque séptico fue de 2.37 ± 5.88 vs 13.22 ± 15.84 con p valor de &lt; 0.001. La eficacia de procalcitonina para diagnosticar sepsis (criterios sepsis 3), sensibilidad 60%, especificidad 75.4%, valor predictivo positivo 68.8%, valor predictivo negativo 67.6% y el área bajo la curva de la característica operativa del receptor fue de 0.767.  Conclusión:  La procalcitonina al ingreso en la Unidad de Cuidados Intensivos sirve como un biomarcador para el diagnóstico de sepsis/choque séptico; sin embargo, no se debe utilizar como prueba única, siempre en conjunto con los criterios diagnósticos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract:  Introduction:  Sepsis and septic shock are the main causes of admission to intensive care units, in the world it is estimated that 20-30 million cases of sepsis occur annually. One third or the half of these cases die.  Objective:  The objective of this study was to evaluate the diagnostic efficiency of procalcitonin in sepsis and septic shock.  Material and methods:  We perform an analytical, prospective, longitudinal observational study from September 1st, 2017 to May 31st, 2018, in the intensive care unit, procalcitonin as well as the classification of sepsis or septic shock criteria of SEPSIS-3 were taken at the time of admission, and the diagnostic efficiency of these biomarkers was performed.  Results:  171 patients were admitted to the ICU in this period, diagnosis of admission 63 (40.9%) admitted with sepsis, and of them 36 (57.1%) with septic shock, 91 (59.1%) with other diagnoses; It was APACHE II, quick-SOFA and SOFA 12.83 ( ± 7.92), 1.11 ( ± 0.92), 4.64 ( ± 3.03) in controls vs 22.45 ( ± 7.24), 2.14 ( ± 0.83), 8.18 ( ± 3.50) in patients with Sepsis or septic shock, the three p &lt; 0.001. The determination of procalcitonin in controls vs patients with sepsis / septic shock was: 2.37  ± 5.88 vs 13.22  ± 15.84 with p value of &lt; 0.001. The efficacy of procalcitonin for diagnosing sepsis (sepsis criteria 3), sensitivity 60%, specificity 75.4%, positive predictive value 68.8%, negative predictive value 67.6% and the area under the curve of the operative characteristic of the receiver was 0.767.  Conclusion:  In conclusion, procalcitonin on admission to the intensive care unit serves as a biomarker for the diagnosis of sepsis/septic shock, however it should not be used as a single test, always in conjunction with the diagnostic criteria.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo:  Introdução:  A sepse e o choque séptico são as principais causas de internação nas unidades de terapia intensiva; estima-se que 20 a 30 milhões de casos de sepse ocorram anualmente no mundo. Destes casos, entre um terço e metade falecem.  Objetivo:  O objetivo deste estudo foi avaliar a eficiência diagnóstica da procalcitonina na sepse e choque séptico.  Material e métodos:  Realizou-se um estudo observacional analítico, prospectivo, longitudinal, no período de 1o de setembro de 2017 a 31 de maio de 2018 na Unidade de Terapia Intensiva (UTI). No momento da admissão todos os pacientes foram submetidos ao estudo de procalcitonina, bem como a classificação de acordo aos critérios de sepse ou choque séptico do SEPSIS-3 e efetuou-se a eficiência diagnóstica desses biomarcadores.  Resultados:  171 pacientes foram internados na UTI nesse período, diagnóstico de internação 63 (40.9%) internados com sepse, sendo 36 (57.1%) com choque séptico, 91 (59.1%) com outros diagnósticos; O APACHE II, quick-SOFA e SOFA 12.83 (± 7.92), 1.11 (± 0.92), 4.64 (± 3.03) nos controles contra 22.45 (± 7.24), 2.14 (± 0.83), 8.18 (± 3.50) nos pacientes com sepse ou choque séptico, todos os três com valor de p &lt; 0.001. Em relação à determinação de procalcitonina nos controles vs pacientes com sepse/choque séptico foi: 2.37 ± 5.88 vs 13.22 ± 15.84 com valor de p &lt; 0.001. A eficácia da procalcitonina para o diagnóstico de sepse (critérios de sepse 3), sensibilidade de 60%, especificidade de 75.4%, valor preditivo positivo de 68.8%, valor preditivo negativo de 67.6% e área sob a curva da característica operatória do receptor foi de 0.767.  Conclusão:  Em conclusão, a procalcitonina no momento da admissão na unidade de terapia intensiva serve como biomarcador para o diagnóstico de sepse/choque séptico, no entanto deve ser usada sempre em conjunto com os critérios diagnósticos.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Eficiencia diagnóstica]]></kwd>
<kwd lng="es"><![CDATA[procalcitonina]]></kwd>
<kwd lng="es"><![CDATA[sepsis]]></kwd>
<kwd lng="es"><![CDATA[choque séptico]]></kwd>
<kwd lng="en"><![CDATA[Diagnostic efficiency]]></kwd>
<kwd lng="en"><![CDATA[procalcitonin]]></kwd>
<kwd lng="en"><![CDATA[sepsis]]></kwd>
<kwd lng="en"><![CDATA[septic shock]]></kwd>
<kwd lng="pt"><![CDATA[Eficiência diagnóstica]]></kwd>
<kwd lng="pt"><![CDATA[procalcitonina]]></kwd>
<kwd lng="pt"><![CDATA[sepse]]></kwd>
<kwd lng="pt"><![CDATA[choque séptico]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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