<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2448-8909</journal-id>
<journal-title><![CDATA[Medicina crítica (Colegio Mexicano de Medicina Crítica)]]></journal-title>
<abbrev-journal-title><![CDATA[Med. crít. (Col. Mex. Med. Crít.)]]></abbrev-journal-title>
<issn>2448-8909</issn>
<publisher>
<publisher-name><![CDATA[Colegio Mexicano de Medicina Crítica A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2448-89092018000100048</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Dexametasona y edema cerebral peritumoral. ¿Cuándo, cuánto y hasta cuándo?]]></article-title>
<article-title xml:lang="en"><![CDATA[Dexamethasone and peritumoral cerebral edema. When, how and how far?]]></article-title>
<article-title xml:lang="pt"><![CDATA[Dexametasona e edema cerebral peritumoral quando, quanto e até quando?]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Lara Lino]]></surname>
<given-names><![CDATA[Zaira Iraís]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sánchez Díaz]]></surname>
<given-names><![CDATA[Jesús Salvador]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martínez Rodríguez]]></surname>
<given-names><![CDATA[Enrique Antonio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pascual Epigmenio]]></surname>
<given-names><![CDATA[Samuel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Asiain Velázquez]]></surname>
<given-names><![CDATA[José Antonio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Peniche Moguel]]></surname>
<given-names><![CDATA[Karla Gabriela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García Méndez]]></surname>
<given-names><![CDATA[Rosalba Carolina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Calyeca Sánchez]]></surname>
<given-names><![CDATA[María Verónica]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Mexicano del Seguro Social Centro Médico Nacional «Adolfo Ruiz Cortines» Unidad Médica de Alta Especialidad Núm. 14]]></institution>
<addr-line><![CDATA[Veracruz ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Centro Médico ABC  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>02</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>02</month>
<year>2018</year>
</pub-date>
<volume>32</volume>
<numero>1</numero>
<fpage>48</fpage>
<lpage>52</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2448-89092018000100048&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2448-89092018000100048&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2448-89092018000100048&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: Los esteroides se han usado desde 1960 y, aunque están vinculados a efectos secundarios potenciales, desempeñan un papel decisivo en el tratamiento del edema cerebral asociado con tumores cerebrales de origen primario o secundario. Por otro lado, los esteroides juegan un rol de suma importancia dentro del manejo inicial, considerando que la mayoría de los tumores desencadena edema vasogénico. Presentamos el caso de una mujer de 48 años de edad con desviación de la comisura labial, hemiparesia hemicorporal izquierda y somnolencia secundarias a tumoración temporal derecha; fue tratada con 8 mg de dexametasona intravenosa cada ocho horas, con mejoría de sus signos y síntomas (reversión de la hemiparesia fasciocorporal izquierda y mejoría del estado de conciencia). Debido a sus propiedades farmacológicas, la dexametasona se considera el esteroide de elección para el tratamiento del edema cerebral peritumoral, tiene un mínimo efecto mineralocorticoide, alta potencia y una vida media más prolongada que el resto, aunque cualquier otro esteroide podría ser eficaz si se administra en dosis equivalentes. Actualmente, no se tiene definida la dosis, el tiempo de tratamiento y el esquema de reducción ideal respecto al uso de dexametasona en el paciente con edema cerebral peritumoral; las recomendaciones encontradas son dispares.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: Steroids have been used since 1960, and even though they are associated with potential side effects, they play a decisive role in treating cerebral edema associated with primary or secondary brain tumors. On the other hand, steroids play a very important role within the initial management, considering that most tumors trigger vasogenic edema. We present the case of a 48-year-old woman with deviation of the labial commissure, left hemicorporal hemiparesis and somnolence secondary to a right temporal tumor; she was treated with dexamethasone 8 mg intravenously every eight hours, with the improvement of signs and symptoms (reversal of left fasciocorporal hemiparesis and improvement of the state of consciousness). Due to its pharmacological properties, dexamethasone is considered the steroid of choice for the treatment of peritumoral cerebral edema; it has a minimal mineralocorticoid effect, high potency and a longer half-life than the rest, although any other steroid could be effective if administered in equivalent doses. Currently, the dose, treatment time and ideal reduction scheme regarding the use of dexamethasone in the patient with cerebral peritumoral edema have not been defined, and the recommendations found are very different.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo: Os esteróides têm sido usados desde 1960, e embora eles estão associados com os efeitos colaterais potenciais desempenham um papel decisivo no tratamento do edema cerebral associado a tumores cerebrais primários ou secundários. Por outro lado, os esteróides desempenham um papel muito importante no tratamento inicial, considerando que a maioria dos tumores desencadeam edema vasogênico. Apresentamos o caso de uma mulher de 48 anos de idade, com desvio da comissura labial, hemiparesia hemicorporal esquerda e sonolência secundária à tumoração temporal direita tratada com 8 mg de dexametasona por via intravenosa a cada 8 horas com melhora dos sinais e sintomas (reversão de hemiparesia fasciocorporal esquerda e melhoria do estado de consciência). Devido a suas propriedades farmacológicas, a dexametasona é considerado o esteróide de eleição para o tratamento de edema cerebral peritumoral, tem um efeito mineralocorticóide mínimo, alta potência e uma vida média mais longa do que o resto, embora qualquer outro esteróide poderia ser eficaz se administrado em doses equivalentes. Atualmente não foram definidas a dose, o tempo de tratamento e o esquema de redução ideal em relação ao uso de dexametasona no paciente com edema cerebral peritumoral, encontrando diferentes recomendações.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Esteroides]]></kwd>
<kwd lng="es"><![CDATA[edema cerebral peritumoral]]></kwd>
<kwd lng="en"><![CDATA[Steroids]]></kwd>
<kwd lng="en"><![CDATA[peritumoral cerebral edema]]></kwd>
<kwd lng="pt"><![CDATA[Esteróides]]></kwd>
<kwd lng="pt"><![CDATA[edema cerebral peritumoral]]></kwd>
</kwd-group>
</article-meta>
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