<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2448-8771</journal-id>
<journal-title><![CDATA[Anestesia en México]]></journal-title>
<abbrev-journal-title><![CDATA[Anest. Méx.]]></abbrev-journal-title>
<issn>2448-8771</issn>
<publisher>
<publisher-name><![CDATA[Federación Mexicana de Colegios de Anestesiología A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2448-87712017000400086</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Pez cebra (Danio rerio) y anestesia. Un modelo animal alternativo para realizar investigación biomédica básica]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vargas-Vargas]]></surname>
<given-names><![CDATA[Rafael Antonio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Pontificia Universidad Javeriana Facultad de Medicina Departamento de Ciencias Fisiológicas]]></institution>
<addr-line><![CDATA[Bogotá ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2017</year>
</pub-date>
<volume>29</volume>
<fpage>86</fpage>
<lpage>96</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2448-87712017000400086&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2448-87712017000400086&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2448-87712017000400086&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La investigación biomédica básica es una necesidad en el campo de la salud, pues muchas sustancias y procedimientos son evaluados para garantizar el beneficio de los pacientes, en quienes finalmente serán empleados. Sin embargo existen limitaciones en nuestros países para realizar este tipo de investigación, debido a la alta inversión que demanda, especialmente debido a la infraestructura y el cuidado que los modelos animales tradicionales empleados requieren, los cuales deben cumplir con normas bioéticas específicas. El contar con un modelo animal de bajo costo y alta versatilidad puede fomentar la investigación preclínica en especial en el área de anestesiología. El pez cebra es un modelo animal emergente con muchas cualidades que lo posicionan como una alternativa atractiva para realizar investigación biomédica básica: tiene alta fecundidad, posee un desarrollo rápido desde el estadio embrionario hasta adulto y el costo de la infraestructura, los insumos y los reactivos necesarios para su crianza y reproducción son bajos. El presente trabajo es una revisión narrativa que muestra estudios que han empleado peces para investigación de fármacos y protocolos de anestesia. De igual forma se presentan las características generales del pez cebra y algunos trabajos de investigación básica en el campo de la anestesiología en los cuales se ha empleado como animal de experimentación. Esta información puede ser útil para profesionales e investigadores del área de la anestesiología interesados en realizar investigación biomédica básica con el pez cebra como modelo de estudio.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Basic biomedical research is a necessity in the health field, in order to evaluate diverse substances and procedures and to ensure the benefit of patients who will employ them. However there are limitations in our countries for this type of research because of the high budget demand, especially due to infrastructure and care that traditional animal models require and which must meet specific ethical standards. Having an animal model of low cost and high versatility can encourage preclinical research, especially in the field of anesthesiology. The zebrafish is an emerging animal model with many characteristics that places it as an attractive alternative model for basic biomedical research: it has high fertility, quick development since the embryonic stage to adult and the cost of infrastructure, supplies and reagents needed for breeding and reproduction are low. This work is a narrative review and the aim is to present studies showing where fish were used for drug research and to develop protocols with anesthetics. In addition, the general characteristics of zebrafish and some basic research work in the field of anesthesiology in which the zebrafish has been used as a model are presented. This information can be useful for professionals and researchers interested in conducting basic biomedical research with zebrafish as a low cost animal model.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Pez cebra]]></kwd>
<kwd lng="es"><![CDATA[anestesiología]]></kwd>
<kwd lng="es"><![CDATA[investigación biomédica básica]]></kwd>
<kwd lng="es"><![CDATA[anestésicos]]></kwd>
<kwd lng="es"><![CDATA[modelos animales]]></kwd>
<kwd lng="en"><![CDATA[Zebrafish]]></kwd>
<kwd lng="en"><![CDATA[anesthesiology]]></kwd>
<kwd lng="en"><![CDATA[anesthetics]]></kwd>
<kwd lng="en"><![CDATA[biomedical basic research]]></kwd>
<kwd lng="en"><![CDATA[animal models]]></kwd>
</kwd-group>
</article-meta>
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