<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2448-6760</journal-id>
<journal-title><![CDATA[Veterinaria México OA]]></journal-title>
<abbrev-journal-title><![CDATA[Veterinaria México OA]]></abbrev-journal-title>
<issn>2448-6760</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional Autónoma de México, Facultad de Medicina Veterinaria y Zootecnia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2448-67602023000100409</article-id>
<article-id pub-id-type="doi">10.22201/fmvz.24486760e.2023.1084</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Evaluación de la toxicidad aguda y subaguda del compuesto alfa inyectable (fosfato disódico de 5-cloro-2-(metiltio)-6-(1-naftiloxi)1H-benzimidazol) en ratas]]></article-title>
<article-title xml:lang="en"><![CDATA[Acute toxicity assessment and subacute of compound alpha injectable (5-chloro-2-(methylthio)-6-(1naphthyloxy)-1H-benzimidazole) in rats]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Zapata-Arenas]]></surname>
<given-names><![CDATA[Abel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gracia-Mora]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Castillo]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Lezama-Ramírez]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rico-Morales]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bustamante-García]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ibarra-Velarde]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional Autónoma de México Facultad de Medicina Veterinaria y Zootecnia Departamento de Parasitología]]></institution>
<addr-line><![CDATA[CDMX ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Nacional Autónoma de México Facultad de Química Departamento de Química Inorgánica y Nuclear]]></institution>
<addr-line><![CDATA[CDMX ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Nacional Autónoma de México Facultad de Química Departamento de Química Orgánica y Farmacia]]></institution>
<addr-line><![CDATA[CDMX ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad Nacional Autónoma de México Facultad de Medicina Veterinaria y Zootecnia Departamento de Patología]]></institution>
<addr-line><![CDATA[CDMX ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Universidad Nacional Autónoma de México Facultad de Química Unidad de Investigación Preclínica (UNIPREC)]]></institution>
<addr-line><![CDATA[CDMX ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af6">
<institution><![CDATA[,Universidad Nacional Autónoma de México Facultad de Química Departamento de Biología]]></institution>
<addr-line><![CDATA[CDMX ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<volume>10</volume>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2448-67602023000100409&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2448-67602023000100409&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2448-67602023000100409&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen El objetivo del trabajo fue evaluar la toxicidad aguda y subaguda del compuesto alfa inyectable en ratas Hsd Han: WIST. En la toxicidad aguda, las ratas fueron inoculadas con las dosis de 2 000, 1 000, 500, 100 o 10 mg/kg vía intramuscular. Los resultados del análisis histopatológico no mostraron cambios aparentes con las dosis utilizadas. Aunque 2 animales murieron con las dosis de 2 000 mg/kg, y en el grupo de 1 000 mg/kg, también murió un animal. En el estudio de toxicidad subaguda, las ratas inoculadas con las dosis repetidas de 8, 24 y 40 mg/kg, no presentaron cambios significativos en el porcentaje de peso corporal tanto en hembras como en machos (P = 0.5930). En las hembras, se observaron diferencias estadísticas en los parámetros bioquímicos séricos de glucosa y colesterol en el grupo inoculado con 8 mg/kg en comparación con el control. Mientras que el hematocrito de los grupos de 8, 24 y 40 mg/kg y el recuento de plaquetas en el de 24 mg/kg, tuvo diferencias significativas (P = 0.0110) en comparación con el grupo control en las hembras. En los machos, las diferencias estadísticas ocurrieron en el recuento de eritrocitos y en el Volumen Corpuscular Medio (VCM) en los grupos tratados con 8 y 40 mg/kg. Sin embargo, estos valores son normales según la literatura. Los hallazgos histopatológicos no mostraron cambios aparentes, por lo que se concluye que el compuesto alfa inyectable tiene un amplio margen de seguridad.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract The objective of this work was to evaluate the acute and subacute toxicity of the injectable alpha compound to Hsd Han: WIST rats. For the acute toxicity assessment, rats were inoculated with doses of 2 000, 1 000, 500, 100, or 10 mg/kg alpha compound intramuscularly. The results of histopathological analysis did not show apparent changes with the doses used. Notably, 2 animals died after treatment with the 2 000 mg/kg dose, and one animal died in the 1 000 mg/kg group. In the subacute toxicity study, neither male nor female rats inoculated with repeated doses of 8, 24, and 40 mg/kg alpha compound showed significant changes in percent body weight (P = 0.5930). Among the females, significant differences were observed for the serum biochemical parameters glucose and cholesterol in the group inoculated with 8 mg/kg compared to the control. The hematocrit values in the 8, 24 and 40 mg/kg groups and the platelet count in the 24 mg/kg group were significantly different (P = 0.0110) among the females compared to the control group. For the male rats, significant differences were found in erythrocyte count and mean corpuscular volume (MCV) in the groups treated with 8 and 40 mg/kg. However, these values are normal according to the literature. The histopathological evaluations did not show apparent changes, so it is concluded that the alpha compound has a wide margin of safety after injection.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Compuesto Alfa]]></kwd>
<kwd lng="es"><![CDATA[Fasciolicida]]></kwd>
<kwd lng="es"><![CDATA[Toxicidad aguda y subaguda]]></kwd>
<kwd lng="es"><![CDATA[Ratas]]></kwd>
<kwd lng="en"><![CDATA[Alpha compound]]></kwd>
<kwd lng="en"><![CDATA[Fasciolicide]]></kwd>
<kwd lng="en"><![CDATA[acute and subacute Toxicity]]></kwd>
<kwd lng="en"><![CDATA[Rats]]></kwd>
</kwd-group>
</article-meta>
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