<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2448-6132</journal-id>
<journal-title><![CDATA[Abanico veterinario]]></journal-title>
<abbrev-journal-title><![CDATA[Abanico vet]]></abbrev-journal-title>
<issn>2448-6132</issn>
<publisher>
<publisher-name><![CDATA[Sergio Martínez González]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2448-61322020000100501</article-id>
<article-id pub-id-type="doi">10.21929/abavet2020.8</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Estudio exploratorio de la genotoxicidad de vacunas recombinantes para tuberculosis bovina]]></article-title>
<article-title xml:lang="en"><![CDATA[Exploratory study of the genotoxicity from recombinant bovine tuberculosis vaccines]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ramos-Ibarra]]></surname>
<given-names><![CDATA[María]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Villa-Castellanos]]></surname>
<given-names><![CDATA[José]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Barba-León]]></surname>
<given-names><![CDATA[Jeannette]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Flores-Valdez]]></surname>
<given-names><![CDATA[Mario]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Zavala-Aguirre]]></surname>
<given-names><![CDATA[Luis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Torres Bugarín]]></surname>
<given-names><![CDATA[Olivia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Guadalajara  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Guadalajara  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco, A.C.  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad Autónoma de Guadalajara  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Universidad Autónoma de Guadalajara  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2020</year>
</pub-date>
<volume>10</volume>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2448-61322020000100501&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2448-61322020000100501&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2448-61322020000100501&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN: La vacuna BCG (bacilo Calmette-Guérin) para el control de la tuberculosis bovina tiene eficacia variable y se requiere la generación y prueba de nuevas vacunas. Por ello se realizó un estudio exploratorio para evaluar la genotoxicidad de dos potenciales vacunas, recombinantes antituberculosa bovina en becerras Holstein Freisan de edad promedio de 9 meses, mediante eritrocitos micronucleados (EMN). Se formaron 5 grupos: 1) Solución salina, 2) El vector pVAX1 (Vector sin inserto), CV), 3) Vacuna Micobacterium bovis (M. bovis) tipo 1 (PE11 [VR1]), 4) Vacuna M. bovis tipo 2 (PPE68 [VR2]), 5) Ambas vacunas (VR1+VR2). A cada organismo se le tomaron 5 muestras de sangre: la primera previa al tratamiento, de la segunda a la cuarta muestra cada 24 horas y la 5ta a los 90 días postratamiento. Las muestras se analizaron con microscopía y se contabilizaron EMN/10,000 eritrocitos. Frecuencias de EMN disminuyeron con la edad (Kruskall Wallis, 95%). Al analizar los tratamientos con respecto al control se identificó menor valor de EMN en los grupos VR2 y en VR1+VR2 (P=0.02). Estos resultados, aparentan efecto citoprotector, no obstante, podría tratarse de efecto mielosupresor (citotóxico) enmascarado, ya que la frecuencia de EMN disminuye al haber mielodepresión. Para confirmar citotoxicidad se sugiere continuar el estudio en organismos más jóvenes.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT: The BCG (Bacillus Calmette-Guérin) vaccine for the control of bovine tuberculosis has variable efficacy and the generation and testing of new vaccines is required. For this reason, an exploratory study was carried out to evaluate the genotoxicity of two potential vaccines, recombinant bovine tuberculosis in Holstein Freisan calves with an average age of 9 months, using micronucleated erythrocytes (MNE). Five groups were formed: 1) Saline solution, 2) The vector pVAX1 (Vector without insert), CV), 3) Vaccine Mycobacterium bovis (M. bovis) type 1 (PE11 [VR1]), 4) Vaccine M. bovis type 2 (PPE68 [VR2]), 5) Both vaccines (VR1 + VR2). Five blood samples were taken from each organism: the first one prior to treatment, the second to the fourth sample every 24 hours and the fifth one 90 days after treatment. The samples were analyzed with microscopy and MNE/10,000 erythrocytes were counted. MNE frequencies decreased with age (Kruskall Wallis, 95%). When analyzing the treatments with respect to the control, a lower value of MNE was identified in the VR2 groups and in VR1 + VR2 (P = 0.02). These results appear to have a cytoprotective effect; however, it could be a masked myelosuppressive (cytotoxic) effect, since the frequency of MNE decreases due to myelosuppression. To confirm cytotoxicity, it is to continue the study in younger organisms suggested.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Genotoxicidad]]></kwd>
<kwd lng="es"><![CDATA[micronúcleos]]></kwd>
<kwd lng="es"><![CDATA[bovinos y vacuna recombinante antituberculosa]]></kwd>
<kwd lng="en"><![CDATA[Genotoxicity]]></kwd>
<kwd lng="en"><![CDATA[micronuclei]]></kwd>
<kwd lng="en"><![CDATA[cattle and recombinant antituberculous vaccine]]></kwd>
</kwd-group>
</article-meta>
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