<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2448-5691</journal-id>
<journal-title><![CDATA[Mundo nano. Revista interdisciplinaria en nanociencias y nanotecnología]]></journal-title>
<abbrev-journal-title><![CDATA[Mundo nano]]></abbrev-journal-title>
<issn>2448-5691</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional Autónoma de México, Instituto de Ciencias Aplicadas y Tecnología]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2448-56912023000200202</article-id>
<article-id pub-id-type="doi">10.22201/ceiich.24485691e.2023.31.69782</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Estudio de los efectos toxicológicos de los nanoplásticos en células de colon]]></article-title>
<article-title xml:lang="en"><![CDATA[Study of the toxicological effects of nanoplastics on colon cells]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cortes Roos]]></surname>
<given-names><![CDATA[Emmanuel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Juárez Moreno]]></surname>
<given-names><![CDATA[Karla]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Centro de Investigación Científica y de Educación Superior de Ensenada Posgrado en Nanociencias ]]></institution>
<addr-line><![CDATA[Ensenada Baja California]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Nacional Autónoma de México Centro de Física Aplicada y Tecnología Avanzada Departamento de Nanotecnología]]></institution>
<addr-line><![CDATA[Juriquilla Querétaro]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2023</year>
</pub-date>
<volume>16</volume>
<numero>31</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2448-56912023000200202&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2448-56912023000200202&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2448-56912023000200202&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN Los residuos plásticos representan una amenaza para el entorno, no solo por su acumulación y contaminación, sino también por su constante degradación y transformación en micro y nanoplásticos (MNPLs). El rango de tamaño de los MNPLs les facilita cruzar las barreras de los organismos, es decir, los mecanismos naturales que protegen al organismo de la entrada de sustancias dañinas o patógenos, convirtiéndose en un factor de riesgo potencial para la salud humana ante sus efectos relativamente desconocidos. La absorción humana de nanoplásticos puede ocurrir de manera no intencional a través de la cadena alimentaria por el consumo de alimentos y bebidas contaminados o posiblemente a través de la migración de partículas nanoplásticas de los materiales de empaque a los productos alimenticios, por lo que evaluar la seguridad y toxicidad de los MNPLs es una preocupación que exige datos fiables. En esta revisión, nos enfocaremos a la literatura publicada en torno a los estudios sobre la evaluación de los efectos de los MNPLs en células epiteliales de colon. Estos trabajos han evaluado el peligro de los MNPLs mediante pruebas de viabilidad celular, integridad de las membranas, localización y translocación de MNPs, inducción de especies reactivas de oxígeno y daño genotóxico para tener una visión integral de sus efectos potencialmente dañinos. La mayoría de los plásticos producidos por la industria están compuestos por diferentes tipos de polímeros, y dada la limitación tecnológica para obtener muestras ambientales se trabaja principalmente con modelos de partículas micro y nanoplásticas sintetizadas.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Plastic waste represents a threat to the environment, not only because of its accumulation and contamination, but also because of the constant degradation it undergoes, leading to its transformation into micro and nanoplastics (MNPLs). The size range of MNPLs makes it easier for them to cross the barriers of organisms, that is, the natural mechanisms that protect the organism from the entry of harmful substances or pathogens, becoming a potential risk factor for human health due to its relatively unknown effects. Human absorption of nanoplastics can occur unintentionally through the food chain through consumption of contaminated food and beverages or possibly through migration of nanoplastic particles from packaging materials to food products, then it is a concern that requires reliable data to assess its safety. In this review, we focus on the literature on research studies in which the effects of MNPLs on colon epithelial cells have been evaluated. These works have evaluated the danger of MNPLs through tests of cell viability, membrane integrity, localization and translocation of MNPs, induction of reactive oxygen species and genotoxic damage to have a comprehensive view of their potentially harmful effects. Most of the plastics produced by the industry are composed of different types of polymers, and given the technological limitation to obtain environmental samples, we work mainly with models of synthesized micro and nanoplastic particles.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[nanoplásticos]]></kwd>
<kwd lng="es"><![CDATA[microplásticos]]></kwd>
<kwd lng="es"><![CDATA[colon]]></kwd>
<kwd lng="es"><![CDATA[citotoxicidad]]></kwd>
<kwd lng="es"><![CDATA[nanotoxicología]]></kwd>
<kwd lng="en"><![CDATA[nanoplastics]]></kwd>
<kwd lng="en"><![CDATA[microplastics]]></kwd>
<kwd lng="en"><![CDATA[colon]]></kwd>
<kwd lng="en"><![CDATA[cytotoxicity]]></kwd>
<kwd lng="en"><![CDATA[nanotoxicology]]></kwd>
</kwd-group>
</article-meta>
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