<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2448-5691</journal-id>
<journal-title><![CDATA[Mundo nano. Revista interdisciplinaria en nanociencias y nanotecnología]]></journal-title>
<abbrev-journal-title><![CDATA[Mundo nano]]></abbrev-journal-title>
<issn>2448-5691</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional Autónoma de México, Instituto de Ciencias Aplicadas y Tecnología]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2448-56912018000100065</article-id>
<article-id pub-id-type="doi">10.22201/ceiich.24485691e.2018.20.62715</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Toxicidad de los nanomateriales de interés biomédico en los sistemas biológicos]]></article-title>
<article-title xml:lang="en"><![CDATA[Toxicity of nanomaterials of biomedical interest in biological systems]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vázquez-Muñoz]]></surname>
<given-names><![CDATA[Roberto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Huerta-Saquero]]></surname>
<given-names><![CDATA[Alejandro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional Autónoma de México Centro de Nanociencias y Nanotecnología ]]></institution>
<addr-line><![CDATA[Ensenada Baja California]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Centro de Investigación Científica y de Educación Superior de Ensenada  ]]></institution>
<addr-line><![CDATA[Ensenada Baja California]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2018</year>
</pub-date>
<volume>11</volume>
<numero>20</numero>
<fpage>65</fpage>
<lpage>75</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2448-56912018000100065&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2448-56912018000100065&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2448-56912018000100065&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: En este artículo hacemos una breve revisión de la importancia de evaluar la toxicidad de los nanomateriales de interés biomédico (NMIB) que se usan como herramientas de diagnóstico y tratamiento. El desarrollo de nuevas terapias y medicamentos basados en la nanotecnología crece rápidamente debido a las ventajas con respecto a las terapias tradicionales, lo que ha impulsado la diversificación y producción masiva de dichos nanomateriales. Entre las más comunes son las nanopartículas (NPS) orgánicas y las NPS metálicas. Otros nanomateriales son los puntos cuánticos o las nanoestructuras de carbono. Finalmente, se insiste en la necesidad de evaluar su impacto real en el entorno, por presentar desafíos experimentales únicos, debido a su tamaño y sus interacciones con el medio y los sistemas biológicos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: In this article, we briefly review the importance of evaluating the toxicity of nanomaterials of biomedical interest (NMIB) that are used as diagnostic and treatment tools. The development of new therapies and medicines based on nanotechnology is growing rapidly due to the advantages over traditional therapies, which has driven the diversification and mass production of these nanomaterials. Among the most common are organic nanoparticles (NPS) and metal NPS. Other nanomaterials are quantum dots or carbon nanostructures. Finally, the need to evaluate its real impact on the environment, which presents unique experimental challenges due to its size and its interactions with the environment and biological systems, is stressed.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[nanotoxicología]]></kwd>
<kwd lng="es"><![CDATA[nanomateriales biomédicos]]></kwd>
<kwd lng="es"><![CDATA[nanomedicina]]></kwd>
<kwd lng="en"><![CDATA[nanotoxicology]]></kwd>
<kwd lng="en"><![CDATA[biomedical nanomaterials]]></kwd>
<kwd lng="en"><![CDATA[nanomedicine]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Arora]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Rajwade]]></surname>
<given-names><![CDATA[J. M.]]></given-names>
</name>
<name>
<surname><![CDATA[Paknikar]]></surname>
<given-names><![CDATA[K. M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Nanotoxicology and in vitro studies: The need of the hour]]></article-title>
<source><![CDATA[Toxicology and Applied Pharmacology]]></source>
<year>2012</year>
<volume>258</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>151-65</page-range><publisher-name><![CDATA[Elsevier Inc.]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Capaldi Arruda]]></surname>
<given-names><![CDATA[S. C.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Nanoparticles applied to plant science: A review]]></article-title>
<source><![CDATA[Talanta]]></source>
<year>2015</year>
<volume>131</volume>
<page-range>693-705</page-range></nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Nanochemistry and nanomedicine for nanoparticle-based diagnostics and Therapy]]></article-title>
<source><![CDATA[Chemical Reviews]]></source>
<year>2016</year>
<page-range>2826-85</page-range></nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Giesy]]></surname>
<given-names><![CDATA[J. P.]]></given-names>
</name>
<name>
<surname><![CDATA[Xie]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The dose makes the poison]]></article-title>
<source><![CDATA[Science of The Total Environment]]></source>
<year>2018</year>
<volume>621</volume>
<page-range>649-53</page-range></nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cox]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Silver and titanium dioxide nanoparticle toxicity in plants: A review of current research]]></article-title>
<source><![CDATA[Plant Physiology and Biochemistry]]></source>
<year>2016</year>
<volume>107</volume>
<page-range>147-63</page-range><publisher-name><![CDATA[Elsevier Masson SAS]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B6">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cupaioli]]></surname>
<given-names><![CDATA[F. A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Engineered nanoparticles. How brain friendly is this new guest?]]></article-title>
<source><![CDATA[Progress in Neurobiology]]></source>
<year>2014</year>
<volume>119-120</volume>
<page-range>20-38</page-range><publisher-name><![CDATA[Elsevier Ltd]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B7">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Elsaesser]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Howard]]></surname>
<given-names><![CDATA[C. V.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Toxicology of nanoparticles]]></article-title>
<source><![CDATA[Advanced Drug Delivery Reviews]]></source>
<year>2012</year>
<volume>64</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>129-37</page-range><publisher-name><![CDATA[Elsevier B.V.]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B8">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Foladori]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[La política pública de nanotecnología en México]]></article-title>
<source><![CDATA[Revista Iberoamericana de Ciencia, Tecnología y Sociedad]]></source>
<year>2016</year>
<volume>12</volume>
<numero>34</numero>
<issue>34</issue>
<page-range>1-12</page-range></nlm-citation>
</ref>
<ref id="B9">
<nlm-citation citation-type="">
<collab>Grand View Reseach</collab>
<source><![CDATA[Healthy Snack Market Size Worth $32.8 Billion By 2025 | CAGR: 5.1%, Grand View Research]]></source>
<year>2017</year>
</nlm-citation>
</ref>
<ref id="B10">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gunsolus]]></surname>
<given-names><![CDATA[I. L.]]></given-names>
</name>
<name>
<surname><![CDATA[Haynes]]></surname>
<given-names><![CDATA[C. L.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Analytical aspects of nanotoxicology]]></article-title>
<source><![CDATA[Analytical Chemistry]]></source>
<year>2016</year>
<volume>88</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>451-79</page-range></nlm-citation>
</ref>
<ref id="B11">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Malysheva]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Lombi]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Voelcker]]></surname>
<given-names><![CDATA[N. H.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Bridging the divide between human and environmental nanotoxicology]]></article-title>
<source><![CDATA[Nature Nanotechnology]]></source>
<year>2015</year>
<volume>10</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>835844</page-range></nlm-citation>
</ref>
<ref id="B12">
<nlm-citation citation-type="book">
<source><![CDATA[Nanotechnology]]></source>
<year>2016</year>
<publisher-name><![CDATA[European Commission]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B13">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Nlate]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Ruiz]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Astruc]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Blais]]></surname>
<given-names><![CDATA[J.-C.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Ferrocenylsilylation of dendrons: a fast convergent route to redox-stable ferrocene dendrimers]]></article-title>
<source><![CDATA[Chemical Communications]]></source>
<year>2000</year>
<volume>5</volume>
<page-range>417-8</page-range></nlm-citation>
</ref>
<ref id="B14">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Panyam]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Labhasetwar]]></surname>
<given-names><![CDATA[V.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Biodegradable nanoparticles for drug and gene delivery to cells and tissue]]></article-title>
<source><![CDATA[Advanced Drug Delivery Reviews]]></source>
<year>2003</year>
<volume>55</volume>
<numero>20</numero>
<issue>20</issue>
<page-range>329-47</page-range></nlm-citation>
</ref>
<ref id="B15">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pelaz]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Diverse applications of nanomedicine]]></article-title>
<source><![CDATA[ACS Nano]]></source>
<year>2017</year>
<volume>11</volume>
<numero>20</numero>
<issue>20</issue>
<page-range>23132381</page-range></nlm-citation>
</ref>
<ref id="B16">
<nlm-citation citation-type="journal">
<collab>PEN</collab>
<article-title xml:lang=""><![CDATA[Project on Emerging Nanotechnologies]]></article-title>
<source><![CDATA[Consumer Products Inventory]]></source>
<year>2013</year>
</nlm-citation>
</ref>
<ref id="B17">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pérez Valencia]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Desarrolla CENAM patrones y métodos de medición para nanomateriales]]></article-title>
<source><![CDATA[conacytprensa]]></source>
<year>2017</year>
</nlm-citation>
</ref>
<ref id="B18">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rai]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Bioactivity of noble metal nanoparticles decorated with biopolymers and their application in drug delivery]]></article-title>
<source><![CDATA[International Journal of Pharmaceutics]]></source>
<year>2015</year>
<volume>496</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>159-72</page-range><publisher-name><![CDATA[Elsevier B.V.]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B19">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Re]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
<name>
<surname><![CDATA[Moresco]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Masserini]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Nanoparticles for neuroimaging]]></article-title>
<source><![CDATA[Journal of Physics D: Applied Physics]]></source>
<year>2012</year>
<volume>45</volume>
<numero>7</numero>
<issue>7</issue>
</nlm-citation>
</ref>
<ref id="B20">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Robbens]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Eco-, geno- and human toxicology of bio-active nanoparticles for biomedical applications]]></article-title>
<source><![CDATA[Toxicology]]></source>
<year>2010</year>
<volume>269</volume>
<numero>2-3</numero>
<issue>2-3</issue>
<page-range>170-81</page-range></nlm-citation>
</ref>
<ref id="B21">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sajid]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Impact of nanoparticles on human and environment: Review of toxicity factors, exposures, control strategies, and future prospects]]></article-title>
<source><![CDATA[Environmental Science and Pollution Research]]></source>
<year>2014</year>
<volume>22</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>4122-43</page-range></nlm-citation>
</ref>
<ref id="B22">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Vale]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Manufactured nanoparticles in the aquatic environment-biochemical responses on freshwater organisms: A critical overview]]></article-title>
<source><![CDATA[Aquatic Toxicology]]></source>
<year>2016</year>
<volume>170</volume>
<page-range>162-74</page-range></nlm-citation>
</ref>
<ref id="B23">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Vance]]></surname>
<given-names><![CDATA[M. E.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Nanotechnology in the real world: Redeveloping the nanomaterial consumer products inventory]]></article-title>
<source><![CDATA[Beilstein Journal of Nanotechnology]]></source>
<year>2015</year>
<volume>6</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>1769-80</page-range></nlm-citation>
</ref>
<ref id="B24">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Vázquez-Muñoz]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Avalos-Borja]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Castro-Longoria]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Ultrastructural analysis of Candida albicans when exposed to silver nanoparticles]]></article-title>
<source><![CDATA[PLoS ONE]]></source>
<year>2014</year>
<volume>9</volume>
<numero>10</numero>
<issue>10</issue>
</nlm-citation>
</ref>
<ref id="B25">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Vázquez-Muñoz]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Toxicity of silver nanoparticles in biological systems: Does the complexity of biological systems matter?]]></article-title>
<source><![CDATA[Toxicology letters]]></source>
<year>2017</year>
<volume>276</volume>
<page-range>11-20</page-range><publisher-name><![CDATA[Elsevier]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B26">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Weissig]]></surname>
<given-names><![CDATA[V.]]></given-names>
</name>
<name>
<surname><![CDATA[Pettinger]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
<name>
<surname><![CDATA[Murdock]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Nanopharmaceuticals (part 1): Products on the market]]></article-title>
<source><![CDATA[International Journal of Nanomedicine]]></source>
<year>2014</year>
<volume>9</volume>
<page-range>4357</page-range></nlm-citation>
</ref>
<ref id="B27">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Yang]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Comparative study of cytotoxicity, oxidative stress and genotoxicity induced by four typical nanomaterials: The role of particle size, shape and composition]]></article-title>
<source><![CDATA[Journal of Applied Toxicology]]></source>
<year>2009</year>
<volume>29</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>69-78</page-range></nlm-citation>
</ref>
<ref id="B28">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Yildirimer]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Toxicological considerations of clinically applicable nanoparticles]]></article-title>
<source><![CDATA[Nano Today]]></source>
<year>2011</year>
<volume>6</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>585-607</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
