<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2444-6483</journal-id>
<journal-title><![CDATA[Endoscopia]]></journal-title>
<abbrev-journal-title><![CDATA[Endoscopia]]></abbrev-journal-title>
<issn>2444-6483</issn>
<publisher>
<publisher-name><![CDATA[Asociación Mexicana de Endoscopia Gastrointestinal A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2444-64832019000600051</article-id>
<article-id pub-id-type="doi">10.24875/end.m19000049</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Factores asociados a esteatosis pancreática en pacientes con adenocarcinoma de páncreas diagnosticada por ultrasonido endoscópico]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Tróchez-Mejía]]></surname>
<given-names><![CDATA[César Fernando]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Aguilar-Moreno]]></surname>
<given-names><![CDATA[Raúl Uvaldo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Robles-Rivera]]></surname>
<given-names><![CDATA[Frida Jazmin]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hernández-Guerrero]]></surname>
<given-names><![CDATA[Angélica]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mora]]></surname>
<given-names><![CDATA[José Guillermo de la]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Nacional de Cancerología Servicio de Endoscopía Gastrointestinal ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2019</year>
</pub-date>
<volume>31</volume>
<fpage>51</fpage>
<lpage>56</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2444-64832019000600051&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2444-64832019000600051&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2444-64832019000600051&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción: El cáncer de páncreas sigue siendo el cáncer más letal del mundo, debido a su baja tasa de supervivencia y mal pronóstico. El diagnóstico temprano y la planificación del manejo son, por lo tanto, esenciales para obtener resultados clínicos óptimos en estos pacientes. Condiciones metabólicas como la obesidad, la diabetes mellitus y la esteatosis pancreática también se han considerado factores de riesgo para el cáncer de páncreas.  Objetivo: Identificar los factores asociados e implicaciones clínicas de esteatosis pancreática en pacientes con adenocarcinoma ductal de páncreas.  Material y métodos: Se realizó un estudio observacional, descriptivo y comparativo, de cohorte retrospectivo, de todos los ultrasonidos endoscópicos realizados en pacientes con tumor de páncreas tipo adenocarcinoma ductal en la unidad de endoscopía gastrointestinal del Instituto Nacional de Cancerología, entre el período de Junio del 2018 a Junio del 2019. El diagnóstico de cáncer de páncreas fue realizado basándose en su histología tomada por biopsia por aspiración por aguja fina. Se revisaron los expedientes electrónicos de los pacientes en busca de: comorbilidades (Diabetes mellitus, hipertensión arterial), antecedente de pancreatitis, Karnofsky, índice de masa corporal, presencia de metástasis, estadificación del tumor, número de ganglios, sitio del tumor por ultrasonido endoscópico (USE), tamaño del tumor, quimioterapia, tratamiento quirúrgico otorgado. Se comparó mediante tablas cruzadas el nivel de significancia mediante Chi (cuadrada) de Pearson. Aplicación de medidas de tendencia central, riesgo relativo, correlación spearman. Se realizó análisis estadístico con el paquete SPSS versión 25. Se consideró significancia estadística una p= &lt;0.05.  Resultados: De un total de 30 pacientes (17 F, 13 M), con media de 62 años. Se diagnóstico esteatosis pancreática a 12 (40%) pacientes en el remanente pancreático sano. De los factores clínicos, sólo la Diabetes Mellitus mostró asociación con esteatosis pancreática (p=0.03). Según la clasificación de TNM, se observó que los pacientes con esteatosis pancreática en estadios clínicos más avanzados (p=0.034). Al analizar nódulos linfáticos involucrados, se logró observar que los pacientes con esteatosis pancreática presentan mayor diseminación comparado con los pacientes sin esteatosis pancreática (p=0.01). Los pacientes con esteatosis pancreática mostraron más metástasis a órganos distantes que los que no tenian esteatosis (p=.004). Al realizar la estimación de riesgo relativo de metástasis fue de 13 (2.074-81.4 IC 95%). A todos los pacientes con adenocarcinoma ductal de páncreas y esteatosis pancreática se decidió dar quioterapia paliativa de primera intención (p=0.007).  Conclusión: Los pacientes con esteatosis pancreática tuvieron mayor diseminación a nódulos linfáticos y metástasis, consecuentemente estados clínicos más avanzados.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction: Pancreatic cancer remains the most lethal cancer in the world due to the low survival rate and poor prognosis. Early diagnosis and planned management are therefore essential to obtain optimal clinical results in these patients. Metabolic conditions such as obesity, Diabetes Mellitus and pancreatic steatosis are also considered as risk factors for pancreatic cancer.  Objective: Identify associated factors and implications of pancreatic steatosis in patients with ductal pancreatic adenocarcinoma.  Materials and methods: A retrospective cohort, observational, descriptive and comparative study was conducted of all the endoscopic ultrasounds performed in patients with ductal adenocarcinoma pancreatic tumour in the Gastrointestinal Endoscopy Unit of the National Cancer Institute, during a period between June 2018 and June 2019. The pancreatic cancer diagnosis was performed based on the histology of the biopsy obtained through fine needle aspiration. Electronic clinical history was reviewed in the search of comorbidities (Diabetes Mellitus, Hypertension), the background of pancreatitis, Karnofsky, body mass index, presence of metastasis, tumour staging, lymphatic node number, tumour site determined by endoscopic ultrasound (EUS), tumour size, chemotherapy and surgical treatment recommended. We compare cross tables with a significance level of Pearson Chi-square. Centred research trend measures applied, relative risk, Spearman correlation. The statistical analysis was performed with SPSS version 25 pack. We considered a significant statistic of p=&lt;0.05.  Results: Out of a total of 30 patients (17 F, 13 M) with an average age of 62 years old. Pancreatic steatosis was diagnosed on 12(40%) patients in the remaining healthy pancreas. About the clinical factors, only Diabetes Mellitus showed an association with pancreatic steatosis (p=0.03). According to the TNM classification, pancreatic steatosis was observed in more advanced clinical stages (p=0.034). Upon involved lymphatic node analysis, it was observed that patients with pancreatic steatosis present greater dissemination compared to patients without pancreatic steatosis (p=0.004). The relative risk estimation was of 13 (2.074-81.4 IC 95%). All patients with ductal pancreatic adenocarcinoma and pancreatic steatosis received first intention palliative chemotherapy (p=0.007).  Conclusion: The patients with pancreatic steatosis had greater dissemination to lymph nodes and metastasis, consequently more advanced clinical states.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Ultrasonido endoscópico]]></kwd>
<kwd lng="es"><![CDATA[Esteatosis pancreática]]></kwd>
<kwd lng="es"><![CDATA[Adenocarcinoma de páncreas]]></kwd>
<kwd lng="en"><![CDATA[Endoscopic ultrasound]]></kwd>
<kwd lng="en"><![CDATA[Pancreatic steatosis]]></kwd>
<kwd lng="en"><![CDATA[Pancreatic adenocarcinoma]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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