<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2444-6483</journal-id>
<journal-title><![CDATA[Endoscopia]]></journal-title>
<abbrev-journal-title><![CDATA[Endoscopia]]></abbrev-journal-title>
<issn>2444-6483</issn>
<publisher>
<publisher-name><![CDATA[Asociación Mexicana de Endoscopia Gastrointestinal A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2444-64832019000200077</article-id>
<article-id pub-id-type="doi">10.24875/end.m19000009</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Utilidad de biopsias endoscópicas en pacientes con diarrea crónica no inflamatoria y colonoscopia normal]]></article-title>
<article-title xml:lang="en"><![CDATA[Usefulness of endoscopic biopsies in patients with chronic non-inflammatory diarrhea and normal colonoscopy]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[López-Valenzuela]]></surname>
<given-names><![CDATA[Luis Alberto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Murcio-Pérez]]></surname>
<given-names><![CDATA[Enrique]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hernández-Mondragón]]></surname>
<given-names><![CDATA[Óscar Víctor]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Blanco-Velasco]]></surname>
<given-names><![CDATA[Gerardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Espinosa-Saavedra]]></surname>
<given-names><![CDATA[David]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Palos-Cuellar]]></surname>
<given-names><![CDATA[Raquel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Barragán-Valarezo]]></surname>
<given-names><![CDATA[María]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Ciudad de México  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital de Especialidades UMAE Siglo XXI Servicio de Endoscopia ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2019</year>
</pub-date>
<volume>31</volume>
<numero>2</numero>
<fpage>77</fpage>
<lpage>84</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2444-64832019000200077&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2444-64832019000200077&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2444-64832019000200077&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción: La diarrea crónica se define como un aumento en la frecuencia y volumen de heces con disminución en la consistencia y duración mayor de 4 semanas. La colonoscopia forma parte del arsenal diagnóstico en pacientes con diarrea crónica no inflamatoria (DCNI), sin embargo en estos pacientes la mucosa de colon puede ser normal aun albergando una patología. El rendimiento diagnóstico de la colonoscopia es variable 7-31%, pero puede proporcionar un diagnóstico definitivo y un tratamiento específico.  Objetivo: Evaluar la utilidad de las biopsias endoscópicas en pacientes con diarrea crónica no inflamatoria y colonoscopia normal.  Material y métodos: Se realizó un estudio retrolectivo, transversal, descriptivo y observacional en el periodo de Enero 2013 a Enero 2018. Criterios de inclusión: hombres y mujeres entre 18-90 años con DCNI &gt; 4 semanas, con análisis de laboratorio iniciales normales (hemoglobina, proteína C reactiva, hormona estimulante de tiroides, albúmina), y colonoscopia normal. Criterios de exclusión: pacientes con menos de 4 biopsias de cada segmento derecho e izquierdo de colon, hemorragia de tubo digestivo evidente, examen coprológico con leucocitos fecales y/o sangre oculta en heces positiva, coproparasitoscópicos positivos, coprocultivos positivos, anemia por déficit de hierro, virus de inmunodeficiencia humana/sida; inmunosupresión por fármacos, quimioterapia, neoplasia digestiva, enfermedad inflamatoria intestinal, consumo crónico de AINE por &gt; 6 semanas, cirugía previa de colon, colonoscopia incompleta. Análisis estadístico: Las variables cualitativas se presentan en porcentajes y frecuencias. Para las asociaciones entre variables cuantitativas se utilizó U de Mann-Whitney o t de Student. Para variables cualitativas Chi cuadrada o prueba exacta de Fisher. Se consideró una p &lt; 0.05 estadísticamente significativo. Se utilizó SPSS versión 21.  Resultados: Se revisaron 349 pacientes, 141/349 cumplieron con criterios de inclusión y fueron analizados, colonoscopia con biopsias tuvo una utilidad para un diagnóstico específico en 25/141 (17.7%). Estos hallazgos fueron colitis eosinofílica 11/141 (7.8%), colitis linfocítica 9/141 (6.4%), colitis ulcerativa crónica idiopática 3/141 (2.1%), enfermedad de Crohn 1/141 (0.7%), melanosis coli 1/141 (0.7%). La evolución de la diarrea &lt; 6 meses tiene mayor probabilidad de un diagnóstico específico comparado con aquellos &gt; 6 meses [20/51 (39.2%) contra 5/90 (5.5%)] con un OR de 10.9 (IC 95%: 3.78 - 31.74). Colitis eosinofílica es más probable encontrarla en muestra de biopsias de colon derecho comparada contra colon izquierdo 9/11 (81%) contra 6/11 (54%) (p = 0.001), de igual forma colitis linfocítica 8/9 (88%) contra 5/9 (55%) (p = 0.001).  Conclusiones: La utilidad de las biopsias en pacientes con DCNI y colon macroscópico normal es alta. En nuestro estudio el rendimiento fue del 17.7% para un diagnóstico específico y estos pacientes podrían beneficiarse de un tratamiento definitivo. Estos hallazgos específicos se observaron con mayor frecuencia en pacientes con diarrea crónica no inflamatoria con una evolución &lt; 6 meses, así como en biopsias obtenidas en colon derecho.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction: Colonoscopy is part of the diagnostic arsenal in patients with chronic non-inflammatory diarrhea; however the colon mucosa may be normal. The diagnostic yield of colonoscopy is 7-31%, but it can provide a definitive diagnosis.  Aim: To evaluate the usefulness of endoscopic biopsies in patients with chronic non-inflammatory diarrhea and normal colonoscopy.  Material and Methods: Retrolective, transversal, descriptive study in a period of 5 years. Men and women between 18-90 years with non-inflammatory chronic diarrhea&gt; 4 weeks were included, with normal initial laboratory tests (hemoglobin, C-reactive protein, thyroid-stimulating hormone, albumin), and normal colonoscopy.  Statistical Analysis: Qualitative variables are presented in percentages and frequencies. Qualitative variables Chi2 or Fisher's exact test was used. P value less than 0.05 was considered significant.  Results: 349 patients were reviewed, 141/349 met inclusion criteria. The endoscopic biopsies in normal colonoscopy had a utility for a specific histological diagnosis in 25/141 (17.7%): eosinophilic colitis 11/141 (7.8%), lymphocytic colitis 9/141 (6.4%), ulcerative colitis 3/141 (2.1%), Crohn's disease 1/141 (0.7%), melanosis coli 1/141 (0.7%). The evolution of diarrhea &lt; 6 months is more likely than a specific diagnosis compared &gt; 6 months 20/51 (39.2%) vs 5/90 (5.5%) OR 10.9 (95% IC: 3.78-31.74). Eosinophilic colitis is more likely in the right colon compared to the left colon 9/11 (81%) vs 6/11 (54%) p = 0.001, and lymphocytic colitis 8/9 (88%) vs 5/9 (55%) p = 0.001.  Conclusions: The usefulness of the biopsies in patients with chronic non-inflammatory diarrhea and normal macroscopic colon was 17.7%, these patients could benefit from a definitive treatment. Specific diagnoses were observed more frequently in patients with an evolution &lt; 6 months and right colon biopsies.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Diarrea crónica no inflamatoria]]></kwd>
<kwd lng="es"><![CDATA[Colonoscopia]]></kwd>
<kwd lng="es"><![CDATA[Mucosa normal]]></kwd>
<kwd lng="es"><![CDATA[Hallazgos histológicos]]></kwd>
<kwd lng="en"><![CDATA[Chronic non-inflammatory diarrhea]]></kwd>
<kwd lng="en"><![CDATA[Colonoscopy]]></kwd>
<kwd lng="en"><![CDATA[Normal colonic mucosa]]></kwd>
<kwd lng="en"><![CDATA[Histological findings]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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