<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2444-054X</journal-id>
<journal-title><![CDATA[Cirugía y cirujanos]]></journal-title>
<abbrev-journal-title><![CDATA[Cir. cir.]]></abbrev-journal-title>
<issn>2444-054X</issn>
<publisher>
<publisher-name><![CDATA[Academia Mexicana de Cirugía A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2444-054X2021000600792</article-id>
<article-id pub-id-type="doi">10.24875/ciru.20001050</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Factors associated with locoregional recurrence in penile cancer: a case-control study]]></article-title>
<article-title xml:lang="es"><![CDATA[Factores asociados a recurrencia locoregional en cáncer de pene: un estudio de casos y control]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Zárate-González]]></surname>
<given-names><![CDATA[Aldo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Priego-Niño]]></surname>
<given-names><![CDATA[Alejandro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Salgado-Arroy]]></surname>
<given-names><![CDATA[Victor]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fernández-Vivar]]></surname>
<given-names><![CDATA[Elieser]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Montiel-Jarquín]]></surname>
<given-names><![CDATA[Álvaro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Mexicano del Seguro Social Centro Médico Nacional. General de división &#8220;Manuel Ávila Camacho&#8221; Hospital de Especialidades de Puebla]]></institution>
<addr-line><![CDATA[Puebla de Zaragoza ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<volume>89</volume>
<numero>6</numero>
<fpage>792</fpage>
<lpage>796</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2444-054X2021000600792&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2444-054X2021000600792&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2444-054X2021000600792&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Purpose: Surgical excision of the primary tumor in penile cancer (PC) has shown good local control with a risk of locoregional recurrence (LR) of 4-8%. The magnitude of such risk and the characteristics that distinguish patients who develop LR from those who do not is controversial. Our goal was to estimate, clinical and oncological characteristics, and outcome of LR in a cohort of patients with PC.  Materials and methods: A retrospective, case&#8211;control study of ten patients with LR of PC and ten controls. Using a multivariate analysis for clinical and oncological characteristics was evaluated to determine their association with LR.  Results: Cases and controls were similar in regards to the prevalence of diabetes, age, grade of differentiation, presence of lymphovascular invasion (LVI), and positive margins. In our multiple logistic regression analysis clinical stage (CS), LVI and positive margins were associated with LR. Time to LR had a median of 15 months.  Conclusions: Our study confirms that patients with advanced CS, LVI and positive margins after surgical excision of the primary tumor could have higher risk of LR. We believe that a close oncological follow-up should be done in patients with adverse oncological characteristics.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resúmen  Objetivo: La escisión quirúrgica del tumor primario en cáncer de pene (PC) ha demostrado un buen control local con un riesgo de recurrencia locorregional (LR) del 4-8%. La magnitud del riesgo y las características que distinguen a los pacientes con recurrencia locorregional de los que no la presentan son motivo de controversia. Nuestro objetivo fue analizar características clínicas y oncológicas para establecer su relación LR en una cohorte de pacientes con PC.  Material y métodos: Estudio retrospectivo de casos y controles de 10 pacientes con LR de PC y 10 controles. Mediante un análisis multivariado se analizaron características clínicas y oncológicas y se determinó su asociación con LR.  Resultados: Los casos y controles fueron similares en cuanto a prevalencia de diabetes, edad, grado de diferenciación, invasión linfovascular y márgenes positivos. En nuestro análisis de regresión logística múltiple, el estadio clínico (CS), la invasión linfovascular y los márgenes positivos se asociaron con LR. El tiempo a la LR tuvo una mediana de 15 meses.  Conclusiones: Nuestro estudio confirma que los pacientes con CS avanzado, invasión linfovascular y márgenes positivos podrían tener mayor riesgo de LR. Creemos que debe realizarse un seguimiento oncológico estrecho en pacientes con características oncológicas adversas.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Penile]]></kwd>
<kwd lng="en"><![CDATA[Cancer]]></kwd>
<kwd lng="en"><![CDATA[Locoregional]]></kwd>
<kwd lng="en"><![CDATA[Recurrence]]></kwd>
<kwd lng="es"><![CDATA[Cáncer]]></kwd>
<kwd lng="es"><![CDATA[Pene]]></kwd>
<kwd lng="es"><![CDATA[Recurrencia]]></kwd>
<kwd lng="es"><![CDATA[Locoregional]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Barnholtz-Sloan]]></surname>
<given-names><![CDATA[JS]]></given-names>
</name>
<name>
<surname><![CDATA[Maldonado]]></surname>
<given-names><![CDATA[JL]]></given-names>
</name>
<name>
<surname><![CDATA[Pow-sang]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Guiliano]]></surname>
<given-names><![CDATA[AR]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Incidence trends in primary malignant penile cancer]]></article-title>
<source><![CDATA[Urol Oncol Semin Orig Investig]]></source>
<year>2007</year>
<volume>25</volume>
<page-range>361-7</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Heller]]></surname>
<given-names><![CDATA[DS]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Lesions and neoplasms of the penis:a review]]></article-title>
<source><![CDATA[J Low Genit Tract Dis]]></source>
<year>2016</year>
<volume>20</volume>
<page-range>107-11</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Diorio]]></surname>
<given-names><![CDATA[GJ]]></given-names>
</name>
<name>
<surname><![CDATA[Leone]]></surname>
<given-names><![CDATA[AR]]></given-names>
</name>
<name>
<surname><![CDATA[Spiess]]></surname>
<given-names><![CDATA[PE]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Management of penile cancer]]></article-title>
<source><![CDATA[Urology]]></source>
<year>2016</year>
<volume>96</volume>
<page-range>15-21</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Larke]]></surname>
<given-names><![CDATA[NL]]></given-names>
</name>
<name>
<surname><![CDATA[Thomas]]></surname>
<given-names><![CDATA[SL]]></given-names>
</name>
<name>
<surname><![CDATA[Dos Santos Silva]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Weiss]]></surname>
<given-names><![CDATA[HA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Male circumcision and penile cancer:a systematic review and meta-analysis]]></article-title>
<source><![CDATA[Cancer Causes Control]]></source>
<year>2011</year>
<volume>22</volume>
<page-range>1097-110</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Downes]]></surname>
<given-names><![CDATA[MR]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Review of in situ and invasive penile squamous cell carcinoma and associated non-neoplastic dermatological conditions]]></article-title>
<source><![CDATA[J Clin Pathol]]></source>
<year>2015</year>
<volume>68</volume>
<page-range>333-40</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mosconi]]></surname>
<given-names><![CDATA[AM]]></given-names>
</name>
<name>
<surname><![CDATA[Roila]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Gatta]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Theodore]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Cancer of the penis]]></article-title>
<source><![CDATA[Crit Rev Oncol Hematol]]></source>
<year>2005</year>
<volume>53</volume>
<page-range>165-77</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[McDougal]]></surname>
<given-names><![CDATA[WS]]></given-names>
</name>
<name>
<surname><![CDATA[Kirchner Jr]]></surname>
<given-names><![CDATA[FK]]></given-names>
</name>
<name>
<surname><![CDATA[Edwards]]></surname>
<given-names><![CDATA[RH]]></given-names>
</name>
<name>
<surname><![CDATA[Killion]]></surname>
<given-names><![CDATA[LT]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Treatment of carcinoma of the penis:the case for primary lymphadenectomy]]></article-title>
<source><![CDATA[J Urol]]></source>
<year>1986</year>
<volume>136</volume>
<page-range>38-41</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Leijte]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Kirrander]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Antonini]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Windahl]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Horenblas]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Recurrence patterns of squamous cell carcinoma of the penis:recommendations for follow-up based on a two-centre analysis of 700 patients]]></article-title>
<source><![CDATA[Eur Urol]]></source>
<year>2008</year>
<volume>54</volume>
<page-range>161-8</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Srinivas]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Morse]]></surname>
<given-names><![CDATA[MJ]]></given-names>
</name>
<name>
<surname><![CDATA[Herr]]></surname>
<given-names><![CDATA[HW]]></given-names>
</name>
<name>
<surname><![CDATA[Sogani]]></surname>
<given-names><![CDATA[PC]]></given-names>
</name>
<name>
<surname><![CDATA[Whitmore Jr]]></surname>
<given-names><![CDATA[WF]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Penile cancer:relation of extent of nodal metastasis to survival]]></article-title>
<source><![CDATA[J Urol]]></source>
<year>1987</year>
<volume>137</volume>
<page-range>880-2</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hakenberg]]></surname>
<given-names><![CDATA[OW]]></given-names>
</name>
<name>
<surname><![CDATA[Compérat]]></surname>
<given-names><![CDATA[EM]]></given-names>
</name>
<name>
<surname><![CDATA[Minhas]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Necchi]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Protzel]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Watkin]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[EAU guidelines on penile cancer:2014 update]]></article-title>
<source><![CDATA[Eur Urol]]></source>
<year>2015</year>
<volume>67</volume>
<page-range>142-50</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Slaton]]></surname>
<given-names><![CDATA[JW]]></given-names>
</name>
<name>
<surname><![CDATA[Morgenstern]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Levy]]></surname>
<given-names><![CDATA[DA]]></given-names>
</name>
<name>
<surname><![CDATA[Santos Jr]]></surname>
<given-names><![CDATA[MW]]></given-names>
</name>
<name>
<surname><![CDATA[Tamboli]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Ro]]></surname>
<given-names><![CDATA[JY]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Tumor stage, vascular invasion and the percentage of poorly differentiated cancer:independent prognosticators for inguinal lymph node metastasis in penile squamous cancer]]></article-title>
<source><![CDATA[J Urol]]></source>
<year>2001</year>
<volume>165</volume>
<page-range>1138-42</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Burnett]]></surname>
<given-names><![CDATA[AL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Penile preserving and reconstructive surgery in the management of penile cancer]]></article-title>
<source><![CDATA[Nat Rev Urol]]></source>
<year>2016</year>
<volume>13</volume>
<page-range>249-57</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Djajadiningrat]]></surname>
<given-names><![CDATA[RS]]></given-names>
</name>
<name>
<surname><![CDATA[van Werkhoven]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Meinhardt]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[van Rhijn]]></surname>
<given-names><![CDATA[BW]]></given-names>
</name>
<name>
<surname><![CDATA[Bex]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[van der Poel]]></surname>
<given-names><![CDATA[HG]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Penile sparing surgery for penile cancer-does it affect survival?]]></article-title>
<source><![CDATA[J Urol]]></source>
<year>2014</year>
<volume>192</volume>
<page-range>120-5</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Philippou]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Shabbir]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Malone]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Nigam]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Muneer]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Ralph]]></surname>
<given-names><![CDATA[DJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Conservative surgery for squamous cell carcinoma of the penis:resection margins and long-term oncological control]]></article-title>
<source><![CDATA[J Urol]]></source>
<year>2012</year>
<volume>188</volume>
<page-range>803-8</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Minhas]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Kayes]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Hegarty]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Kumar]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Freeman]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Ralph]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[What surgical resection margins are required to achieve oncological control in men with primary penile cancer?]]></article-title>
<source><![CDATA[BJU Int]]></source>
<year>2005</year>
<volume>96</volume>
<page-range>1040-3</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Albersen]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Parnham]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Joniau]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Sahdev]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Christodoulidou]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Castiglione]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Predictive factors for local recurrence after glansectomy and neoglans reconstruction for penile squamous cell carcinoma]]></article-title>
<source><![CDATA[Urol Oncol]]></source>
<year>2018</year>
<volume>36</volume>
<page-range>141-6</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
