<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2444-054X</journal-id>
<journal-title><![CDATA[Cirugía y cirujanos]]></journal-title>
<abbrev-journal-title><![CDATA[Cir. cir.]]></abbrev-journal-title>
<issn>2444-054X</issn>
<publisher>
<publisher-name><![CDATA[Academia Mexicana de Cirugía A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2444-054X2021000400553</article-id>
<article-id pub-id-type="doi">10.24875/ciru.20001734</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Biomarcadores y endotipos en la sepsis. Nuevas evidencias]]></article-title>
<article-title xml:lang="en"><![CDATA[Biomarkers and sepsis endotypes. New evidence]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Godínez-Vidal]]></surname>
<given-names><![CDATA[Ansony R.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Carrillo-Esper]]></surname>
<given-names><![CDATA[Raúl]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cabello-Aguilera]]></surname>
<given-names><![CDATA[Ricardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital HMG Coyoacán Servicio de Cirugía General ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital HMG Coyoacán Servicio de Terapia Intensiva ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Instituto Nacional de Rehabilitación "Luis Guillermo Ibarra Ibarra" Servicio de Terapia Intensiva ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2021</year>
</pub-date>
<volume>89</volume>
<numero>4</numero>
<fpage>553</fpage>
<lpage>558</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2444-054X2021000400553&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2444-054X2021000400553&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2444-054X2021000400553&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Antecedentes: La sepsis es una causa importante de enfermedad y muerte en todo el mundo, y es un proceso complejo y heterogéneo. Ahora se reconoce que los marcadores biológicos mejoran la clasificación de la sepsis y pueden facilitar la identificación de distintas subclases o endotipos de pacientes.  Objetivo: Analizar los conceptos actuales en biología traslacional que ayudan a entender la heterogeneidad en la respuesta del paciente con sepsis.  Conclusiones: Hay una serie de biomarcadores que podrían ser útiles para construir endotipos compuestos que predicen resultados no complicados en la sepsis. Estos endotipos podrían ayudar a identificar a los pacientes que merecen el inicio temprano de antimicrobianos o la interrupción de estos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Background: Sepsis is an important cause of disease and death worldwide, and it has a complex and heterogeneous disease process. It is now recognized that biological markers improve sepsis classification and may facilitate the identification of different subclasses or endotypes of patients.  Objective: To analyze the current concepts in translational biology that help to understand the heterogeneity in the response of the patient with sepsis.  Conclusions: There are a number of biomarkers that could be useful for constructing endo-compound types that predict uncomplicated results in sepsis. These endotypes could help identify patients who deserve early antimicrobial onset or discontinuation.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Sepsis]]></kwd>
<kwd lng="es"><![CDATA[Biología]]></kwd>
<kwd lng="es"><![CDATA[Endotipos]]></kwd>
<kwd lng="es"><![CDATA[Biomarcadores]]></kwd>
<kwd lng="en"><![CDATA[Sepsis]]></kwd>
<kwd lng="en"><![CDATA[Biology]]></kwd>
<kwd lng="en"><![CDATA[Endotypes]]></kwd>
<kwd lng="en"><![CDATA[Biomarkers]]></kwd>
</kwd-group>
</article-meta>
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