<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2444-054X</journal-id>
<journal-title><![CDATA[Cirugía y cirujanos]]></journal-title>
<abbrev-journal-title><![CDATA[Cir. cir.]]></abbrev-journal-title>
<issn>2444-054X</issn>
<publisher>
<publisher-name><![CDATA[Academia Mexicana de Cirugía A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2444-054X2020000400461</article-id>
<article-id pub-id-type="doi">10.24875/ciru.19001540</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Resultados del tratamiento multidisciplinario en cáncer de laringe. Estudio retrospectivo con seguimiento a 10 años]]></article-title>
<article-title xml:lang="en"><![CDATA[Outcome of multidisciplinary treatment in laryngeal cancer. Retrospective study with 10-years follow-up]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gurrola-Machuca]]></surname>
<given-names><![CDATA[Héctor]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A1b"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Miranda-Aguirre]]></surname>
<given-names><![CDATA[Arturo P.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A1b"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Villavicencio-Quejeiro]]></surname>
<given-names><![CDATA[Michelle]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A2b"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Nuñez-Guardado]]></surname>
<given-names><![CDATA[Gabriela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A2b"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Juárez-Ramiro]]></surname>
<given-names><![CDATA[Alejandro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A3b"/>
</contrib>
</contrib-group>
<aff id="A1a">
<institution><![CDATA[,Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado Centro Médico Nacional 20 de Noviembre Servicio de Cirugía Oncológica]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="A1b">
<institution><![CDATA[,Clínica Multidisciplinaria de Tumores de Cabeza y Cuello  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="A2a">
<institution><![CDATA[,Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado Servicio de Radioterapia Centro Médico Nacional 20 de Noviembre]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="A2b">
<institution><![CDATA[,Clínica Multidisciplinaria de Tumores de Cabeza y Cuello  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="A3a">
<institution><![CDATA[,Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado Centro Médico Nacional 20 de Noviembre Servicio de Oncología Médica]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="A3b">
<institution><![CDATA[,Clínica Multidisciplinaria de Tumores de Cabeza y Cuello  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2020</year>
</pub-date>
<volume>88</volume>
<numero>4</numero>
<fpage>461</fpage>
<lpage>466</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2444-054X2020000400461&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2444-054X2020000400461&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2444-054X2020000400461&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Antecedentes: En cáncer de laringe, el tratamiento multidisciplinario mejora la calidad de vida del paciente y la posibilidad de preservar la laringe. La mayor parte de estos cánceres se presentan localmente avanzados. El objetivo es presentar los resultados de acuerdo con la etapa.  Método: Estudio retrospectivo en el que se analizaron la etapa clínica, el tipo de tratamiento primario, los resultados y la sobrevida.  Resultados: Se incluyeron 451 pacientes. La mediana de edad fue de 66 años. El mayor porcentaje de los tumores se presentó en etapa avanzada (72%) y el sitio más afectado fue la glotis (84.5%). En etapa temprana, el tratamiento más frecuente fue la radioterapia. En las etapas III y IVA, el 65% fueron operables. En la etapa IVB el manejo fue no quirúrgico, con control en el 26% de los casos. La supervivencias a 10 años se relacionaron con la etapa clínica: 81.7% para la etapa I y 0% para las etapas IVB y IVC.  Conclusiones: Los pacientes con cáncer de laringe deben ser tratados de acuerdo con la etapa clínica y mediante un abordaje multidisciplinario. El seguimiento a largo plazo demostró un peor pronóstico para las etapas clínicas avanzadas.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Background: In laryngeal cancer, multidisciplinary treatment improves the patient&#8217;s quality of life and the possibility of preserving the larynx. Most cases occur in a locally advanced stage. The aim is to present the results according to the stage.  Method: A retrospective study which analyzed the clinical stage, type of primary treatment, outcomes, and survival were analyzed.  Results: 451 patients were included. The median age was 66 years. The majority of the tumors presented in advanced stage (72%) and the most affected subsite was the glottis (84.5%). In the early stage the most frequent treatment was radiotherapy as the only treatment modality. In stages III and IVA, 65% were resectable. In stage IVB the management was non-surgical, with control in 26% of the cases. Survival at 10 years was related to the clinical stage: 81.7% for stage I and 0% for stages IVB and IVC.  Conclusions: Patients with laryngeal cancer should be treated according to the clinical stage, through a multidisciplinary approach. Long-term follow-up showed a worse prognosis for advanced clinical stages.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Neoplasias de laringe]]></kwd>
<kwd lng="es"><![CDATA[Laringectomía]]></kwd>
<kwd lng="es"><![CDATA[Quimioterapia de inducción]]></kwd>
<kwd lng="es"><![CDATA[Tratamiento concomitante]]></kwd>
<kwd lng="es"><![CDATA[Biorradioterapia]]></kwd>
<kwd lng="es"><![CDATA[Neoplasias de cabeza y cuello]]></kwd>
<kwd lng="en"><![CDATA[Larynx neoplasm]]></kwd>
<kwd lng="en"><![CDATA[Laryngectomy]]></kwd>
<kwd lng="en"><![CDATA[Induction chemotherapy]]></kwd>
<kwd lng="en"><![CDATA[Chemoradiotherapy]]></kwd>
<kwd lng="en"><![CDATA[Bioradiotherapy]]></kwd>
<kwd lng="en"><![CDATA[Head and neck neoplasm]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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