<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2444-054X</journal-id>
<journal-title><![CDATA[Cirugía y cirujanos]]></journal-title>
<abbrev-journal-title><![CDATA[Cir. cir.]]></abbrev-journal-title>
<issn>2444-054X</issn>
<publisher>
<publisher-name><![CDATA[Academia Mexicana de Cirugía A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2444-054X2020000200233</article-id>
<article-id pub-id-type="doi">10.24875/ciru.19000725</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[La activación plaquetaria como factor desencadenante de la inflamación y la ateroesclerosis]]></article-title>
<article-title xml:lang="en"><![CDATA[Platelet activation as a trigger factor for inflammation and atherosclerosis]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Custodio-Chablé]]></surname>
<given-names><![CDATA[Santiago J.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Lezama]]></surname>
<given-names><![CDATA[Ruth A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Reyes-Maldonado]]></surname>
<given-names><![CDATA[Elba]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Politécnico Nacional Escuela Nacional de Ciencias Biológicas ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2020</year>
</pub-date>
<volume>88</volume>
<numero>2</numero>
<fpage>233</fpage>
<lpage>243</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2444-054X2020000200233&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2444-054X2020000200233&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2444-054X2020000200233&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen Las plaquetas, además de participar en la ateroesclerosis, desempeñan un papel muy activo en la respuesta inmunitaria de esta enfermedad, ya que tienen la capacidad de interaccionar con diversas células inflamatorias, además de secretar citocinas, quimiocinas, factores de crecimiento, etc. Las funciones de las plaquetas van más allá de su interacción con el endotelio, pues participan en crear un ambiente inflamatorio, lo que contribuye a la pérdida de la homeostasis. Por otra parte, las micropartículas derivadas de plaquetas inducen la activación de otras plaquetas y de células endoteliales, y el reclutamiento de leucocitos. Por todo lo anterior, las plaquetas y el ambiente inflamatorio pueden considerarse como posibles blancos terapéuticos para evitar el desarrollo de la ateroesclerosis y los eventos asociados a esta.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Platelets, in addition to participating in atherosclerosis, play a very active role in the immune response of this disease since they have the ability to interact with various inflammatory cells, in addition to secreting cytokines, chemokines, growth factors, etc. The functions of platelets go beyond their interaction with the endothelium, as they participate in creating an inflammatory environment, which contributes to the loss of homeostasis. On the other hand, platelet-derived microparticles induce the activation of other platelets, of endothelial cells and in recruiting leukocytes. For all the above, platelets and the inflammatory environment can be considered as possible therapeutic targets to prevent the development of atherosclerosis and the events associated with it.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Aterosclerosis]]></kwd>
<kwd lng="es"><![CDATA[Inflamación]]></kwd>
<kwd lng="es"><![CDATA[Plaquetas]]></kwd>
<kwd lng="en"><![CDATA[Atherosclerosis]]></kwd>
<kwd lng="en"><![CDATA[Inflammation]]></kwd>
<kwd lng="en"><![CDATA[Platelets]]></kwd>
</kwd-group>
</article-meta>
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