<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2306-4102</journal-id>
<journal-title><![CDATA[Acta ortopédica mexicana]]></journal-title>
<abbrev-journal-title><![CDATA[Acta ortop. mex]]></abbrev-journal-title>
<issn>2306-4102</issn>
<publisher>
<publisher-name><![CDATA[Colegio Mexicano de Ortopedia y Traumatología A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2306-41022024000600411</article-id>
<article-id pub-id-type="doi">10.35366/118294</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Artroplastía total de cadera secundaria a artropatía ocronótica. Reporte de un caso]]></article-title>
<article-title xml:lang="en"><![CDATA[Total hip arthroplasty secondary to ocronotic arthropathy. A case report]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Garcini-Munguia]]></surname>
<given-names><![CDATA[FA]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Dobarganes-Barlow]]></surname>
<given-names><![CDATA[FG]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Esquivel-Solorio]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Guevara-Álvarez]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Negrete-Corona]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rojas-Avilés]]></surname>
<given-names><![CDATA[JL]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Queretano de Alta Especialidad en Ortopedia (IQAEO) Hospital Ángeles de Querétaro ]]></institution>
<addr-line><![CDATA[Qro ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Anáhuac Querétaro  ]]></institution>
<addr-line><![CDATA[México ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2024</year>
</pub-date>
<volume>38</volume>
<numero>6</numero>
<fpage>411</fpage>
<lpage>414</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2306-41022024000600411&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2306-41022024000600411&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2306-41022024000600411&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen:  Introducción:  la alcaptonuria es un trastorno hereditario metabólico raro que se caracteriza por deficiencia de la enzima homogentisato 1,2 dioxigenasa responsable de la oxidación y eliminación renal del ácido homogentísico (AHG), lo que provoca su acumulación. La acumulación excesiva de ácido homogentísico resulta en ocronosis y, posteriormente, en artropatía ocronótica, la cual afecta principalmente a la columna dorsolumbar y las grandes articulaciones que conduce a requerir un reemplazo articular buscando mejorar la función y la calidad de vida.  Caso clínico:  se presenta el caso de una paciente femenina de 67 años de edad con antecedente de alcaptonuria que cursa con un cuadro doloroso difuso en cadera derecha de cuatro años de evolución; a la exploración física, se encuentran manifestaciones clínicas acordes con ocronosis y artropatía ocronótica. Se realizan estudios de imagen donde se evidencia pérdida de espacio articular de cadera derecha, osteofitos y esclerosis acetabular.  Conclusiones:  el reemplazo articular es una terapia efectiva para mejorar la calidad de vida con artropatía secundaria a alcaptonuria; a pesar de ello, se necesita enriquecer la literatura sobre el seguimiento a largo plazo de este tratamiento.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract:  Introduction:  alkaptonuria is a rare hereditary metabolic disorder which is characterized by deficiency of the enzyme homogentisate 1,2 dioxygenase, which is responsible for the oxidation and renal elimination of homogentisic acid (HGA), which causes its accumulation. The excessive accumulation of HGA results in ochronosis and ochronotic arthropathy, which mainly affects the thoracolumbar spine and the large joints, leading to the need for joint replacement seeking to improve function and quality of life.  Clinical case:  hereby is presented a 67-years-old female patient with history of alkaptonuria with diffuse painful right hip of 4 years of evolution. On physical examination, clinical manifestations were found consistent with ochronosis and ochronotic arthropathy. Imaging studies revealed loss of right hip joint space, osteophytes, and acetabular sclerosis.  Conclusions:  joint hip replacement is an effective therapy in improving the quality of life with hip arthropathy secondary to alkaptonuria, despite this, the literature on long-term follow-up about this treatment needs to be enriched.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[alcaptonuria]]></kwd>
<kwd lng="es"><![CDATA[ocronosis]]></kwd>
<kwd lng="es"><![CDATA[artropatía ocronótica]]></kwd>
<kwd lng="es"><![CDATA[artroplastía]]></kwd>
<kwd lng="en"><![CDATA[alkaptonuria]]></kwd>
<kwd lng="en"><![CDATA[ochronosis]]></kwd>
<kwd lng="en"><![CDATA[ochronotic arthropathy]]></kwd>
<kwd lng="en"><![CDATA[arthroplasty]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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