<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2007-8196</journal-id>
<journal-title><![CDATA[Epistemus (Sonora)]]></journal-title>
<abbrev-journal-title><![CDATA[Epistemus (Sonora)]]></abbrev-journal-title>
<issn>2007-8196</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Sonora, División de Ingeniería]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2007-81962025000100201</article-id>
<article-id pub-id-type="doi">10.36790/epistemus.v19i38.424</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Propóleos interfiere con el ciclo celular en células de cáncer de mama]]></article-title>
<article-title xml:lang="en"><![CDATA[Propolis interferes with the Cell Cycle in Breast Cancer Cells]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Calderón Ahumada]]></surname>
<given-names><![CDATA[Andrea]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Alday]]></surname>
<given-names><![CDATA[Efraín]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rascón]]></surname>
<given-names><![CDATA[Lucila]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Velázquez]]></surname>
<given-names><![CDATA[Carlos]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Lipovka]]></surname>
<given-names><![CDATA[Yulia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Sonora  ]]></institution>
<addr-line><![CDATA[Hermosillo Sonora]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Sonora  ]]></institution>
<addr-line><![CDATA[Hermosillo Sonora]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad de Sonora  ]]></institution>
<addr-line><![CDATA[Hermosillo Sonora]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad de Sonora  ]]></institution>
<addr-line><![CDATA[Hermosillo Sonora]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Universidad de Sonora  ]]></institution>
<addr-line><![CDATA[Hermosillo Sonora]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2025</year>
</pub-date>
<volume>19</volume>
<numero>38</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2007-81962025000100201&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2007-81962025000100201&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2007-81962025000100201&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen El cáncer de mama es el cáncer más común en las mujeres de México y en el mundo. Múltiples investigaciones se han centrado en buscar nuevas alternativas para el tratamiento de esta neoplasia, incluyendo el estudio de productos naturales. El propóleos, una resina elaborada por las abejas, tiene una composición química muy variada, que depende de las fuentes botánicas disponibles en la zona geográfica y estación del año de recolección. Su acción antiproliferativa se debe principalmente a la inducción de apoptosis y arresto del ciclo celular. Este artículo ofrece una visión general del cáncer de mama y sus clasificaciones, examina la importancia del ciclo celular y sus diferentes fases, y aborda la complejidad química del propóleos y su actividad biológica. Por último, detalla los mecanismos intracelulares responsables del efecto antiproliferativo del propóleos en el cáncer de mama, con particular énfasis en su capacidad para detener el ciclo celular.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Breast cancer is the most common cancer in women in Mexico and worldwide. Multiple studies have focused on finding new alternatives for the treatment of this neoplasm, including research of natural products. Propolis, a resin produced by bees, has a highly variable chemical composition which depends on the botanical sources available in the geographic area and the season of collection. Its antiproliferative activity is mainly due to induction of apoptosis and cell cycle arrest. This article provides an overview of breast cancer and its classifications, examines the significance of the cell cycle and its different phases, and addresses the chemical complexity of propolis and its biological activity. Finally, it details the intracellular mechanisms responsible for the antiproliferative effects of propolis on breast cancer, with particular emphasis on its ability to halt the cell cycle.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Propóleos]]></kwd>
<kwd lng="es"><![CDATA[cáncer de mama]]></kwd>
<kwd lng="es"><![CDATA[ciclo celular]]></kwd>
<kwd lng="en"><![CDATA[Propolis]]></kwd>
<kwd lng="en"><![CDATA[breast cancer]]></kwd>
<kwd lng="en"><![CDATA[cell cycle]]></kwd>
</kwd-group>
</article-meta>
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