<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2007-8196</journal-id>
<journal-title><![CDATA[Epistemus (Sonora)]]></journal-title>
<abbrev-journal-title><![CDATA[Epistemus (Sonora)]]></abbrev-journal-title>
<issn>2007-8196</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Sonora, División de Ingeniería]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2007-81962025000100101</article-id>
<article-id pub-id-type="doi">10.36790/epistemus.v19i38.357</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Retos en el estudio de membranas biológicas usando simulaciones de dinámica molecular]]></article-title>
<article-title xml:lang="en"><![CDATA[Challenges in the Study of Biological Membranes using Molecular Dynamics Simulations]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Moreno Pérez]]></surname>
<given-names><![CDATA[Nahuel Armando]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Urrutia Bañuelos]]></surname>
<given-names><![CDATA[Efraín]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional Autónoma de México Instituto de Ciencias Físicas ]]></institution>
<addr-line><![CDATA[Cuernavaca Morelos]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Sonora Departamento de Investigación en Física ]]></institution>
<addr-line><![CDATA[Hermosillo Sonora]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2025</year>
</pub-date>
<volume>19</volume>
<numero>38</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2007-81962025000100101&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2007-81962025000100101&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2007-81962025000100101&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: En el estudio de simulaciones de membrana modelo, la selección de componentes resulta crucial. Incluso al considerar solo la bicapa, núcleo esencial de la membrana, distintos lípidos generan variadas interacciones, influyendo en el comportamiento del sistema y dando lugar a diversos procesos biológicos. Considerar escalas temporales adecuadas es esencial, ya que distintos fenómenos biológicos operan en intervalos temporales específicos. La elección de una escala inapropiada podría pasar por alto detalles intrínsecos al fenómeno en estudio. En el presente estudio exploramos dos escalas de simulación: la resolución detallada de todos los átomos y la simplificación de grano grueso, destacando su impacto en precisión y rendimiento computacional. Abordamos la complejidad estudiando componentes individuales, como la bicapa. Este enfoque proporciona una perspectiva valiosa para comprender procesos biológicos complejos en la membrana plasmática, resaltando la importancia de elecciones cuidadosas en la simulación de sistemas biomiméticos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract In the study of model membrane simulations, the selection of components is pivotal. Even when considering only the bilayer, the essential core of the plasma membrane, different lipids generate various interactions, influencing system&#8217;s behavior and giving rise to diverse biological processes. Accounting for appropriate temporal scales is essential, as distinct biological phenomena operate within specific time intervals. Choosing an inappropriate scale might overlook intrinsic details of the phenomenon under investigation. In the present study, we delve into two simulation scales: the detailed resolution of all atoms and the coarse-grained simplification, emphasizing their impact on accuracy and computational performance. We address complexity by studying individual components, such as the bilayer. This approach provides a valuable perspective for comprehending intricate biological processes in the plasma membrane, emphasizing the significance of careful choices in in the simulation of biomimetic systems.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[lípidos]]></kwd>
<kwd lng="es"><![CDATA[bicapa]]></kwd>
<kwd lng="es"><![CDATA[simulaciones]]></kwd>
<kwd lng="es"><![CDATA[membrana]]></kwd>
<kwd lng="es"><![CDATA[fases]]></kwd>
<kwd lng="en"><![CDATA[lipids]]></kwd>
<kwd lng="en"><![CDATA[bilayer]]></kwd>
<kwd lng="en"><![CDATA[simulations]]></kwd>
<kwd lng="en"><![CDATA[membrane]]></kwd>
<kwd lng="en"><![CDATA[phases]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Feig]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Nawrocki]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[Yu]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Challenges and opportunities in connecting simulations with experiment via molecular dynamics of cellular environments]]></article-title>
<source><![CDATA[J. Phys. Conf. Ser]]></source>
<year>2018</year>
<volume>1036</volume>
<numero>1</numero>
<issue>1</issue>
</nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Murray]]></surname>
<given-names><![CDATA[J. D.]]></given-names>
</name>
<name>
<surname><![CDATA[Lange]]></surname>
<given-names><![CDATA[J. J.]]></given-names>
</name>
<name>
<surname><![CDATA[Bennett-Lenane]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[Holm]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Advancing algorithmic drug product development: Recommendations for machine learning approaches in drug formulation]]></article-title>
<source><![CDATA[Eur. J. Pharm. Sci]]></source>
<year>2023</year>
<volume>191</volume>
</nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Vattulainen]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
<name>
<surname><![CDATA[Rog]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Lipid simulations: A perspective on lipids in action]]></article-title>
<source><![CDATA[Cold Spring Harb. Perspect. Biol]]></source>
<year>2011</year>
<volume>3</volume>
<numero>4</numero>
<issue>4</issue>
</nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Heimburg]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
<name>
<surname><![CDATA[Biltonen]]></surname>
<given-names><![CDATA[R. L.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A Monte Carlo simulation study of protein-induced heat capacity changes and lipid-induced protein clustering]]></article-title>
<source><![CDATA[Biophys. J]]></source>
<year>1996</year>
<volume>70</volume>
<page-range>84-96</page-range></nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gu]]></surname>
<given-names><![CDATA[R. X .]]></given-names>
</name>
<name>
<surname><![CDATA[Baoukina]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Tieleman]]></surname>
<given-names><![CDATA[D. P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Phase separation in atomistic simulations of model membranes]]></article-title>
<source><![CDATA[J. Am. Chem. Soc]]></source>
<year>2020</year>
<volume>142</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>2844-56</page-range></nlm-citation>
</ref>
<ref id="B6">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Karami]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Interactions of neutral and protonated Tamoxifen with the DPPC lipid bilayer using molecular dynamics simulation]]></article-title>
<source><![CDATA[Steroids]]></source>
<year>2023</year>
<volume>194</volume>
</nlm-citation>
</ref>
<ref id="B7">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ingólfsson]]></surname>
<given-names><![CDATA[H. I.]]></given-names>
</name>
<name>
<surname><![CDATA[Melo]]></surname>
<given-names><![CDATA[M. N.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Lipid Organization of the plasma membrane]]></article-title>
<source><![CDATA[Journal of the American Chemical Society]]></source>
<year>2014</year>
<volume>136</volume>
<numero>41</numero>
<issue>41</issue>
<page-range>14554-9</page-range></nlm-citation>
</ref>
<ref id="B8">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sezgin]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Giant plasma membrane vesicles to study plasma membrane structure and dynamics]]></article-title>
<source><![CDATA[Biochim. Biophys. Acta. Biomembr]]></source>
<year>2022</year>
<volume>1864</volume>
<numero>4</numero>
<issue>4</issue>
</nlm-citation>
</ref>
<ref id="B9">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Nickels]]></surname>
<given-names><![CDATA[J. D.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Lipid Rafts: Buffers of Cell Membrane Physical Properties]]></article-title>
<source><![CDATA[J. Phys. Chem B]]></source>
<year>2019</year>
<volume>123</volume>
<page-range>2050-6</page-range></nlm-citation>
</ref>
<ref id="B10">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sezgin]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Levental]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
<name>
<surname><![CDATA[Mayor]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Eggeling]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The mystery of membrane organization: Composition, regulation and roles of lipid rafts]]></article-title>
<source><![CDATA[Nature Reviews Molecular Cell Biology]]></source>
<year>2017</year>
<volume>18</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>361-74</page-range></nlm-citation>
</ref>
<ref id="B11">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Veacht]]></surname>
<given-names><![CDATA[S. L.]]></given-names>
</name>
<name>
<surname><![CDATA[Rogers]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
<name>
<surname><![CDATA[Decker]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Shelby]]></surname>
<given-names><![CDATA[S. A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The plasma membranes as an adaptable fluid mosaic]]></article-title>
<source><![CDATA[Biochim. Biophys. Acta Biomembr]]></source>
<year>2023</year>
<volume>1865</volume>
<numero>3</numero>
<issue>3</issue>
</nlm-citation>
</ref>
<ref id="B12">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Doktorova]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Khelashvili]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[Ashkar]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Brown]]></surname>
<given-names><![CDATA[M. F.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Molecular simulations and NMR reveal how lipid fluctuations affect membrane mechanics]]></article-title>
<source><![CDATA[Biophys. J.]]></source>
<year>2022</year>
<volume>122</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>984-1002</page-range></nlm-citation>
</ref>
<ref id="B13">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Qian]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Sharma]]></surname>
<given-names><![CDATA[V. K.]]></given-names>
</name>
<name>
<surname><![CDATA[Clifton]]></surname>
<given-names><![CDATA[L. A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Understanding the structure and dynamics of complex biomembrane interactions by neutron scattering techniques]]></article-title>
<source><![CDATA[Langmuir]]></source>
<year>2020</year>
<volume>36</volume>
<page-range>15189-211</page-range></nlm-citation>
</ref>
<ref id="B14">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Metzler]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Jeon]]></surname>
<given-names><![CDATA[J. H.]]></given-names>
</name>
<name>
<surname><![CDATA[Cherstvy]]></surname>
<given-names><![CDATA[A.G.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Non-brownian diffusion in lipid membranes: experiments and simulations]]></article-title>
<source><![CDATA[Biochim. Biophys. Acta. Biomembr]]></source>
<year>2016</year>
<volume>1858</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>2451-67</page-range></nlm-citation>
</ref>
<ref id="B15">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Porcar]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Gerelli]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[On the lipid flip-flop and phase transition coupling]]></article-title>
<source><![CDATA[Soft Matter]]></source>
<year>2020</year>
<volume>16</volume>
<numero>33</numero>
<issue>33</issue>
<page-range>7696-703</page-range></nlm-citation>
</ref>
<ref id="B16">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wu]]></surname>
<given-names><![CDATA[E. L.]]></given-names>
</name>
<name>
<surname><![CDATA[Cheng]]></surname>
<given-names><![CDATA[X.]]></given-names>
</name>
<name>
<surname><![CDATA[Jo]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Rui]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[Song]]></surname>
<given-names><![CDATA[K. C.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[CHARMM-GUI membrane builder toward realistic biological membrane simulations]]></article-title>
<source><![CDATA[J. Comput. Chem]]></source>
<year>2014</year>
<volume>35</volume>
<numero>27</numero>
<issue>27</issue>
<page-range>1997-2004</page-range></nlm-citation>
</ref>
<ref id="B17">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Marrink]]></surname>
<given-names><![CDATA[S. J.]]></given-names>
</name>
<name>
<surname><![CDATA[Risselada]]></surname>
<given-names><![CDATA[H. J.]]></given-names>
</name>
<name>
<surname><![CDATA[Yefimov]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Tieleman]]></surname>
<given-names><![CDATA[D. P.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The MARTINI force field: Coarse grained model for biomolecular simulations]]></article-title>
<source><![CDATA[J. Phys. Chem. B]]></source>
<year>2007</year>
<volume>111</volume>
<page-range>7812-24</page-range></nlm-citation>
</ref>
<ref id="B18">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rakhshani]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[Dehghanian]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Rahati]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Enhanced GROMACS: toward a better numerical simulation framework]]></article-title>
<source><![CDATA[J. Mol. Model]]></source>
<year>2019</year>
<volume>25</volume>
<numero>12</numero>
<issue>12</issue>
</nlm-citation>
</ref>
<ref id="B19">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Van Der Ploeg]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Berendsen]]></surname>
<given-names><![CDATA[H. J. C.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Molecular dynamics of a bilayer membrane]]></article-title>
<source><![CDATA[J. Chem. Phys]]></source>
<year>1982</year>
<volume>76</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>3271-6</page-range></nlm-citation>
</ref>
<ref id="B20">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Marrink]]></surname>
<given-names><![CDATA[S. J.]]></given-names>
</name>
<name>
<surname><![CDATA[Corradi]]></surname>
<given-names><![CDATA[V.]]></given-names>
</name>
<name>
<surname><![CDATA[Ingólfsson]]></surname>
<given-names><![CDATA[H. I.]]></given-names>
</name>
<name>
<surname><![CDATA[Tieleman]]></surname>
<given-names><![CDATA[D. P.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Computational Modelling of realistic cell membranes]]></article-title>
<source><![CDATA[Chem. Rev]]></source>
<year>2019</year>
<volume>119</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>6184-226</page-range></nlm-citation>
</ref>
<ref id="B21">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Risbo]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Sperotto]]></surname>
<given-names><![CDATA[M. M.]]></given-names>
</name>
<name>
<surname><![CDATA[Mouritsen]]></surname>
<given-names><![CDATA[O. G.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Theory of phase equilibria and critical mixing points in binary lipid bilayers]]></article-title>
<source><![CDATA[J. Chem. Phys]]></source>
<year>1995</year>
<volume>103</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>3643-56</page-range></nlm-citation>
</ref>
<ref id="B22">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mouritsen]]></surname>
<given-names><![CDATA[O. G.]]></given-names>
</name>
<name>
<surname><![CDATA[Bagatolli]]></surname>
<given-names><![CDATA[L. A.]]></given-names>
</name>
</person-group>
<source><![CDATA[Life - as a matter of fat lipids in a membrane biophysics perspective]]></source>
<year>2005</year>
<edition>Segunda edición</edition>
<publisher-loc><![CDATA[Suiza ]]></publisher-loc>
<publisher-name><![CDATA[Springer International Publishing Switzerland]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B23">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Marsh]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Cholesterol-induced fluid membrane domains: A compendium of lipid-raft ternary phase diagrams]]></article-title>
<source><![CDATA[Biochimica et Biophysica Acta - Biomembranes]]></source>
<year>2009</year>
<volume>1788</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>2114-23</page-range></nlm-citation>
</ref>
<ref id="B24">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Levental]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
<name>
<surname><![CDATA[Levental]]></surname>
<given-names><![CDATA[K. R.]]></given-names>
</name>
<name>
<surname><![CDATA[Heberle]]></surname>
<given-names><![CDATA[F. A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Lipid Rafts: Controversies Resolved, Mysteries Remain]]></article-title>
<source><![CDATA[Trends in Cell Biology]]></source>
<year>2020</year>
<volume>30</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>341-53</page-range></nlm-citation>
</ref>
<ref id="B25">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Simons]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[Ikonen]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Functional rafts in cell membranes]]></article-title>
<source><![CDATA[Nature]]></source>
<year>1997</year>
<volume>387</volume>
<page-range>569-72</page-range></nlm-citation>
</ref>
<ref id="B26">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Levental]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
<name>
<surname><![CDATA[Veatch]]></surname>
<given-names><![CDATA[S. L.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The Continuing Mystery of Lipid Rafts]]></article-title>
<source><![CDATA[Journal of Molecular Biology]]></source>
<year>2016</year>
<volume>428</volume>
<numero>24</numero>
<issue>24</issue>
<page-range>4749-64</page-range></nlm-citation>
</ref>
<ref id="B27">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Maldonado Arce]]></surname>
<given-names><![CDATA[A. D.]]></given-names>
</name>
<name>
<surname><![CDATA[Contreras Aburto]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Rosales]]></surname>
<given-names><![CDATA[F. F.]]></given-names>
</name>
<name>
<surname><![CDATA[Arvayo Zatarain]]></surname>
<given-names><![CDATA[J. A.]]></given-names>
</name>
<name>
<surname><![CDATA[Urrutia Bañuelos]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Métodos de simulación computacional en biología]]></article-title>
<source><![CDATA[EPISTEMUS]]></source>
<year>2016</year>
<numero>21</numero>
<issue>21</issue>
<page-range>84-92</page-range></nlm-citation>
</ref>
<ref id="B28">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Allen]]></surname>
<given-names><![CDATA[M. P.]]></given-names>
</name>
<name>
<surname><![CDATA[Tildesley]]></surname>
<given-names><![CDATA[D. J.]]></given-names>
</name>
</person-group>
<source><![CDATA[Computer Simulation of Liquids]]></source>
<year>2017</year>
<edition>2nd. Ed</edition>
<publisher-name><![CDATA[Oxford University Press]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B29">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Frenkel]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Smit]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
</person-group>
<source><![CDATA[Understanding Molecular Simulation From Algorithms to Applications]]></source>
<year>2002</year>
<edition>2nd. Ed</edition>
<publisher-name><![CDATA[Academic Press]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B30">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Parrinello]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Rahman]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Polymorphic transitions in single crystals: A new molecular dynamics method]]></article-title>
<source><![CDATA[J. Appl. Phys]]></source>
<year>1981</year>
<volume>52</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>7182-90</page-range></nlm-citation>
</ref>
<ref id="B31">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Nose]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A unified formulation of the constant temperature molecular dynamics methods]]></article-title>
<source><![CDATA[J. Phys. Chem. Lett]]></source>
<year>1984</year>
<volume>81</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>511-9</page-range></nlm-citation>
</ref>
<ref id="B32">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pastor]]></surname>
<given-names><![CDATA[R. W.]]></given-names>
</name>
<name>
<surname><![CDATA[MacKerell]]></surname>
<given-names><![CDATA[A. D.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Development of the CHARMM force field for lipids]]></article-title>
<source><![CDATA[J. Phys. Chem. Lett]]></source>
<year>2011</year>
<volume>2</volume>
<numero>13</numero>
<issue>13</issue>
<page-range>1526-32</page-range></nlm-citation>
</ref>
<ref id="B33">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Nerenberg]]></surname>
<given-names><![CDATA[P. S.]]></given-names>
</name>
<name>
<surname><![CDATA[Head-Gordon]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[New developments in force fields for biomolecular simulations]]></article-title>
<source><![CDATA[Current Opinion in Structural Biology]]></source>
<year>2018</year>
<volume>49</volume>
<page-range>129-38</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
