<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2007-7459</journal-id>
<journal-title><![CDATA[Horizonte sanitario]]></journal-title>
<abbrev-journal-title><![CDATA[Horiz. sanitario]]></abbrev-journal-title>
<issn>2007-7459</issn>
<publisher>
<publisher-name><![CDATA[Universidad Juárez Autónoma de Tabasco, División Académica de Ciencias de la Salud]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2007-74592024000100039</article-id>
<article-id pub-id-type="doi">10.19136/hs.a23n1.5637</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Aberraciones del cromosoma 9 diagnosticadas en un hospital pediátrico en Tabasco, México]]></article-title>
<article-title xml:lang="en"><![CDATA[Chromosome 9 aberrations diagnosed at a pediatric hospital in Tabasco, Mexico]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez-García]]></surname>
<given-names><![CDATA[Diana Saraí]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gómez-Sandoval]]></surname>
<given-names><![CDATA[Norma]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Díaz-Martínez]]></surname>
<given-names><![CDATA[Rubicel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rivera-Angles]]></surname>
<given-names><![CDATA[Miriam Margot]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Huerta García]]></surname>
<given-names><![CDATA[Elizabeth]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gómez-Valencia]]></surname>
<given-names><![CDATA[Luis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Regional de Alta Especialidad del Niño Dr. Rodolfo Nieto Padrón Laboratorio de citogenética ]]></institution>
<addr-line><![CDATA[Villahermosa Tabasco]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Regional de Alta Especialidad del Niño Dr. Rodolfo Nieto Padrón Laboratorio de citogenética ]]></institution>
<addr-line><![CDATA[Villahermosa Tabasco]]></addr-line>
<country>México</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital Regional de alta Especialidad del Niño Dr. Rodolfo Nieto Padrón  ]]></institution>
<addr-line><![CDATA[Villahermosa Tabasco]]></addr-line>
<country>México</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Hospital Regional de Alta Especialidad del Niño Dr. Rodolfo Nieto Padrón Laboratorio de citogenética ]]></institution>
<addr-line><![CDATA[Villahermosa Tabasco]]></addr-line>
<country>México</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Universidad Juárez Autónoma de Tabasco División Académica Multidisciplinaria de Jalpa de Méndez ]]></institution>
<addr-line><![CDATA[Jalpa de Méndez Tabasco]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af6">
<institution><![CDATA[,Hospital Regional de alta Especialidad del Niño Dr. Rodolfo Nieto Padrón  ]]></institution>
<addr-line><![CDATA[Villahermosa Tabasco]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2024</year>
</pub-date>
<volume>23</volume>
<numero>1</numero>
<fpage>39</fpage>
<lpage>45</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2007-74592024000100039&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2007-74592024000100039&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2007-74592024000100039&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Objetivo: Determinar la frecuencia de pacientes diagnosticados con alteraciones del cromosoma 9 en un hospital pediátrico entre los años 2012 y 2022.  Materiales y métodos: Se realizó un estudio retrospectivo en 2932 pacientes que acudieron a la consulta de genética de un hospital pediátrico de Tabasco, México, de enero de 2012 a diciembre de 2022, a partir de los resultados del diagnóstico cromosómico en sangre periférica.  Resultados: El 14.76% (433/2932) presentaron alteraciones cromosómicas. El cromosoma más frecuentemente involucrado fue el número 21 en el 83.37% (361/433), seguido del cromosoma sexual X con el 5.31% (23/433) y el cromosoma 9 con 3.69% (16/433). En relación al cromosoma 9, el 50% (8/16) correspondieron a variantes morfológicas (9qh+), seguido de la inversión pericéntrica en 3 de los casos (18.75%), la deleción en 2 (12.5%), inserción en 1 (6.6%), anillo en 1 (6.6%), y una derivación (6.6%).  Conclusión: Los resultados citogenéticos encontrados, de acuerdo a los motivos de referencia de los pacientes, sugiere la realización del cariotipo en sangre periférica como herramienta útil en el diagnóstico de enfermedades con sospecha genética.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Objective: To determine the frequency of patients diagnosed with chromosome 9 disorders in a pediatric hospital between the years 2012 and 2022.  Materials and methods: A cross-sectional and descriptive study was performed in 2932 patients who attended the genetics consultation of a pediatric hospital in Tabasco, Mexico, from January 2012 to December 2022, based on the results of chromosomal diagnosis in peripheral blood.  Results: Chromosomal alterations were present in 14.76% (433/2932). The most frequently involved chromosome was number 21 in 83.37% (361/433), followed by sex chromosome X with 5.31% (23/433) and chromosome 9 with 3.69% (16/433). Regarding chromosome 9, 50% (8/16) corresponded to morphological variants (9qh+), followed by pericentric inversion in 3 of the cases (18.75%), deletion in 2 (12.5%), insertion in 1 (6.6%), ring in 1 (6.6%), and a shunt (6.6%).  Conclusion: The cytogenetic results found, according to the patients' reasons for referral, suggest the performance of peripheral blood karyotyping as a useful tool in the diagnosis of diseases with genetic suspicion.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Inversión cromosómica]]></kwd>
<kwd lng="es"><![CDATA[Cariotipo]]></kwd>
<kwd lng="es"><![CDATA[Infertilidad]]></kwd>
<kwd lng="en"><![CDATA[Chromosomal inversion]]></kwd>
<kwd lng="en"><![CDATA[Karyotype]]></kwd>
<kwd lng="en"><![CDATA[Infertility]]></kwd>
</kwd-group>
</article-meta>
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