<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2007-4298</journal-id>
<journal-title><![CDATA[Botanical Sciences]]></journal-title>
<abbrev-journal-title><![CDATA[Bot. sci]]></abbrev-journal-title>
<issn>2007-4298</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Botánica de México A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2007-42982019000300355</article-id>
<article-id pub-id-type="doi">10.17129/botsci.2187</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Amarisolide A and pedalitin as bioactive compounds in the antinociceptive effects of Salvia circinata (Lamiaceae)]]></article-title>
<article-title xml:lang="es"><![CDATA[Amarisólida A y pedalitina como compuestos bioactivos en el efecto antinociceptivo de Salvia circinata (Lamiaceae)]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Moreno-Pérez]]></surname>
<given-names><![CDATA[Gabriel Fernando]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González-Trujano]]></surname>
<given-names><![CDATA[María Eva]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martínez-Gordillo]]></surname>
<given-names><![CDATA[Martha Juana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[San Miguel-Chávez]]></surname>
<given-names><![CDATA[Rubén]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Basurto-Peña]]></surname>
<given-names><![CDATA[Francisco Alberto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Dorazco-González]]></surname>
<given-names><![CDATA[Alejandro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Aguirre-Hernández]]></surname>
<given-names><![CDATA[Eva]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional Autónoma de México Facultad de Ciencias ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Nacional Autónoma de México  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Colegio de Postgraduados  ]]></institution>
<addr-line><![CDATA[Texcoco Estado de México]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Universidad Nacional Autónoma de México Instituto de Biología ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af6">
<institution><![CDATA[,Universidad Nacional Autónoma de México Instituto de Química ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2019</year>
</pub-date>
<volume>97</volume>
<numero>3</numero>
<fpage>355</fpage>
<lpage>365</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2007-42982019000300355&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2007-42982019000300355&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2007-42982019000300355&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract:  Background: Salvia circinata is an endemic species of Mexico used in the folk medicine of Santiago Huauclilla, Oaxaca, mainly as remedy for gastrointestinal diseases.  Hypothesis:  If the extracts of Salvia circinata have secondary metabolites with antinociceptive activity, then the behavior of nociception in the model of &#8220;whriting&#8221; in mice will decrease.  Specie studied: Salvia circinata Cav. (Lamiaceae).  Study site and years of study: Salvia circinata was collected in Santiago Huauclilla, Oaxaca, in July 2014.  Methods:  Firstly, the acute toxicity of S. circinata extracts was evaluated to calculate the LD50 with OECD method. Then, dose-response curves of the antinociceptive effect of S. circinata organic and aqueous extracts (1, 10, 30, 100, and 300 mg/kg) were obtained in the writhing test in mice. Furthermore, chromatographic techniques were applied to isolate the compounds and were identified by comparison of the values of 1H NMR, 13C NMR and ESIMS reported in the literature.  Results:  Our data showed significant antinociceptive activity in all the tested extracts. Amarisolide A and pedalitin were isolated in the ethyl acetate and methanol extracts, respectively and assayed at doses of 1, 5 and 10 mg/kg, i.p. All the compounds decreased nociception in mice in at least 50 % from a minimal dosage of 1 mg/kg, i.p. and in a similar manner than the reference drug ketorolac (1 mg/kg, i.p.).  Conclusions:  Our findings give evidence that Salvia circinata possesses antinociceptive activity depending on the presence of several known bioactive constituents, reinforcing its use in the Mexican traditional medicine to alleviate abdominal pain.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen:  Antecedentes: Salvia circinata es una especie endémica de México, utilizada en Santiago Huauclilla, Oaxaca como remedio para enfermedades gastrointestinales.  Hipótesis:  Si los extractos de Salvia circinata tienen metabolitos con actividad antinociceptiva, entonces disminuirán la conducta nociceptiva en el modelo writhing.  Especie estudiada: Salvia circinata Cav. (Lamiaceae).  Lugar de estudio y años de estudio: Salvia circinata se colectó en Santiago Huauclilla, Oaxaca, en julio de 2014.  Métodos:  Se evaluó la toxicidad aguda (DL50) de los extractos de S. circinata mediante el método de la OECD. Se realizaron las curvas dosis-respuesta del efecto antinociceptivo de los extractos de S. circinata (1, 10, 30, 100, and 300 mg/kg) en el modelo de writhing en ratones. Además, se utilizaron técnicas cromatográficas para aislar los compuestos y se identificaron por comparación de los datos de 1H RMN, 13C RMN y ESIMS reportados en la literatura.  Resultados:  Nuestros resultados muestran una actividad antinociceptiva significativa en todos los extractos evaluados. La amarisólida A y la pedalitina fueron aisladas de los extractos de acetato de etilo y metanol, respectivamente y evaluadas a dosis de 1, 5 y 10 mg/kg, i.p. Todos los compuestos disminuyeron la nocicepción en los ratones en al menos el 50 % a partir de una dosis mínima de 1 mg/kg, i.p. y de manera similar al ketorolaco (1 mg/kg, i.p.).  Conclusiones:  Nuestros hallazgos dan evidencia de que Salvia circinata posee actividad antinociceptiva debido a varios constituyentes bioactivos conocidos, con ello se refuerza su uso en la medicina tradicional mexicana para el alivio del dolor abdominal.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Abdominal pain]]></kwd>
<kwd lng="en"><![CDATA[amarisolide A]]></kwd>
<kwd lng="en"><![CDATA[Lamiaceae]]></kwd>
<kwd lng="en"><![CDATA[pedalitin]]></kwd>
<kwd lng="en"><![CDATA[Salvia circinata]]></kwd>
<kwd lng="es"><![CDATA[Dolor abdominal]]></kwd>
<kwd lng="es"><![CDATA[amarisólida A]]></kwd>
<kwd lng="es"><![CDATA[Lamiaceae]]></kwd>
<kwd lng="es"><![CDATA[pedalitina]]></kwd>
<kwd lng="es"><![CDATA[Salvia circinata]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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