<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2007-4085</journal-id>
<journal-title><![CDATA[Revista mexicana de urología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. mex. urol.]]></abbrev-journal-title>
<issn>2007-4085</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Mexicana de Urología]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2007-40852020000200010</article-id>
<article-id pub-id-type="doi">10.48193/rmu.v80i2.544</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Intracavernous application of autologous bone marrow stem cells for medical treatment-refractory erectile dysfunction: A case report]]></article-title>
<article-title xml:lang="es"><![CDATA[Aplicación intracavernosa de células madre autólogas de médula ósea para el manejo de disfunción eréctil refractaria: Experiencia de un caso]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Robles-Torres]]></surname>
<given-names><![CDATA[José Iván]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mancías-Guerra]]></surname>
<given-names><![CDATA[Consuelo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Garza-Bedolla]]></surname>
<given-names><![CDATA[Alejandra]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gómez-Guerra]]></surname>
<given-names><![CDATA[Lauro Salvador]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Autónoma de Nuevo León Hospital Universitario &#8220;Dr. José Eleuterio González&#8221; ]]></institution>
<addr-line><![CDATA[Monterrey Nuevo León]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2020</year>
</pub-date>
<volume>80</volume>
<numero>2</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2007-40852020000200010&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2007-40852020000200010&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2007-40852020000200010&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Clinical case description:  A 61-year-old man with severe erectile dysfunction related to diabetes mellitus of long duration was treated through intracavernous stem cell application. Transplantation of autologous bone marrow stem cells through a single intracavernous injection was performed. Clinical response, Doppler ultrasound of the penis, and adverse events were evaluated during the 50-week follow-up. The highest clinical response was reported at week 12, but it diminished thereafter. At the end of follow-up, ultrasound identified the presence of neovascularization emerging from the cavernous arteries.  Relevance:  Numerous preclinical trials have demonstrated efficacy and safety, but there is insufficient clinical evidence showing promising results.  Clinical implications:  No adverse events were detected, and ultrasound revealed hemodynamic changes that were possibly related to the therapy. The source and dosage of stem cells, as well as subsequent therapeutic applications, pose questions that remain to be answered.  Conclusions:  Stem cell therapy for erectile dysfunction is a field of research that has sparked interest in numerous scientific groups, but clinical experience is still limited.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Descripción del caso clínico:  Presentamos un masculino de 61 años con disfunción eréctil severa relacionada a diabetes mellitus de larga evolución manejado con células madre intracavernosas. Se realizó trasplante autólogo de células madre obtenidas de médula ósea en dosis única aplicadas vía intracavernosa. Se realizó un seguimiento de 50 semanas que evaluó la respuesta clínica, la ecografía doppler del pene y los eventos adversos. La respuesta clínica más alta se reportó en la semana 12, pero posteriormente disminuyó. Los hallazgos ecográficos revelaron la presencia de neovascularización que emerge de las arterias cavernosas al final del seguimiento.  Relevancia:  Numerosos estudios preclínicos han demostrado eficacia y seguridad. Se ha reportado evidencia clínica limitada que muestra resultados prometedores.  Implicaciones clínicas:  No se detectaron eventos adversos y la ecografía mostró cambios hemodinámicos, posiblemente relacionados con la terapia. Las aplicaciones posteriores, la fuente de células madre y la dosis siguen siendo preguntas sin responder.  Conclusiones:  La terapia con células madre para la disfunción eréctil es un campo que ha despertado el interés de numerosos grupos científicos. Sin embargo, la experiencia clínica sigue siendo limitada.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Cell therapy]]></kwd>
<kwd lng="en"><![CDATA[Erectile dysfunction]]></kwd>
<kwd lng="en"><![CDATA[Stem cells]]></kwd>
<kwd lng="es"><![CDATA[terapia celular]]></kwd>
<kwd lng="es"><![CDATA[disfunción eréctil]]></kwd>
<kwd lng="es"><![CDATA[células madre]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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