<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2007-4085</journal-id>
<journal-title><![CDATA[Revista mexicana de urología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. mex. urol.]]></abbrev-journal-title>
<issn>2007-4085</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Mexicana de Urología]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2007-40852020000100401</article-id>
<article-id pub-id-type="doi">10.48193/rmu.v80i1.373</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Tumor renal de células claras como debut de la enfermedad de Von Hippel-Lindau: reporte de caso]]></article-title>
<article-title xml:lang="en"><![CDATA[Clear cell renal cell carcinoma detection leading to von Hippel-Lindau disease diagnosis: A case report]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martínez-Valeriano]]></surname>
<given-names><![CDATA[David Alejandro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vásquez-Ciriaco]]></surname>
<given-names><![CDATA[Sergio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Jiménez-Rivera]]></surname>
<given-names><![CDATA[Elisa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García-Manzano]]></surname>
<given-names><![CDATA[Roberto Armando]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Barker-Antonio]]></surname>
<given-names><![CDATA[Alan]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Dávila-Ruiz]]></surname>
<given-names><![CDATA[Ediel Osvaldo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García-Espinoza]]></surname>
<given-names><![CDATA[Jaime Aron]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Secretaría de Salud Hospital Regional de Alta Especialidad de Oaxaca ]]></institution>
<addr-line><![CDATA[ Oaxaca]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>02</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>02</month>
<year>2020</year>
</pub-date>
<volume>80</volume>
<numero>1</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2007-40852020000100401&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2007-40852020000100401&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2007-40852020000100401&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Antecedentes: La enfermedad de Von Hippel Lindau se debe a mutaciones del gen VHL (un supresor tumoral) que provoca aparición de distintas neoplasias en sistema nervioso central, ojo y abdomen. Su incidencia es baja y su importancia estriba en que el carcinoma renal de células claras representa la entidad con mayor tasa de letalidad en pacientes afectados por esta enfermedad.  Caso clínico: Femenino de 45 años que presenta múltiples antecedentes familiares de neoplasias del sistema nervioso central y abdomen, que acude por aparición de tumoración abdominal. Se corrobora por imagen una neoplasia renal por lo que se somete a nefrectomía radical izquierda y se confirma el diagnóstico de carcinoma renal de células claras. En su abordaje posterior se integra el diagnóstico de Enfermedad de Von Hippel Lindau tipo I.  Conclusiones: La enfermedad de Von Hippel Lindau presenta diversas manifestaciones neoplásicas de las cuales el carcinoma renal de células claras representa la entidad con mayor morbimortalidad, por lo que su detección temprana cuando existen antecedentes familiares es esencial para mejorar el pronóstico y diagnosticar a tiempo otras neoplasias vistas en la enfermedad.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Background: Von Hippel-Lindau disease is caused by mutations of the VHL tumor-suppressor gene and results in the development of different neoplasias in the central nervous system, eye, and abdomen. Its incidence is low, but patients that develop clear cell renal cell carcinoma have the highest mortality rate.  Clinical case: A 45-year-old woman, with a family history of central nervous system and abdominal neoplasias, sought medical attention due to a progressively growing mass in the left flank. A kidney tumor was corroborated through an imaging study, and she underwent left radical nephrectomy. The diagnosis of clear cell renal cell carcinoma was confirmed. In the subsequent approach, she was also diagnosed with von Hippel-Lindau type I disease.  Conclusions:  Von Hippel-Lindau disease presents with different neoplastic manifestations, and that of clear cell renal cell carcinoma has the highest morbidity and mortality rates. When there is a family history, its early detection is essential for improving outcome and opportunely diagnosing other neoplasias resulting from the disease.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[von Hippel Lindau]]></kwd>
<kwd lng="en"><![CDATA[Clear cell renal cell carcinoma]]></kwd>
<kwd lng="en"><![CDATA[Radical nephrectomy]]></kwd>
<kwd lng="es"><![CDATA[Von Hippel Lindau]]></kwd>
<kwd lng="es"><![CDATA[Carcinoma renal de células claras]]></kwd>
<kwd lng="es"><![CDATA[nefrectomía radical]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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