<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2007-1124</journal-id>
<journal-title><![CDATA[Revista mexicana de ciencias pecuarias]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. mex. de cienc. pecuarias]]></abbrev-journal-title>
<issn>2007-1124</issn>
<publisher>
<publisher-name><![CDATA[Instituto Nacional de Investigaciones Forestales, Agrícolas y Pecuarias]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2007-11242023000100122</article-id>
<article-id pub-id-type="doi">10.22319/rmcp.v14i1.6241</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Insulin-like growth factor 1 (IGF-1) concentrations in synovial fluid of sound and osteoarthritic horses, and its correlation with proinflammatory cytokines IL-6 and TNF]]></article-title>
<article-title xml:lang="es"><![CDATA[Concentraciones del factor de crecimiento similar a la insulina 1 (IGF-1) en el líquido sinovial de caballos sanos y osteoartríticos, y su correlación con las citoquinas proinflamatorias IL-6 y TNF&#945;]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García-Lacy F.]]></surname>
<given-names><![CDATA[Fernando]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Méndez-Cruz]]></surname>
<given-names><![CDATA[Sara Teresa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Reyes-Vivas]]></surname>
<given-names><![CDATA[Horacio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Dávila-Borja]]></surname>
<given-names><![CDATA[Victor Manuel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Barrera-Morales]]></surname>
<given-names><![CDATA[Jose Alejandro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gutiérrez-Ospina]]></surname>
<given-names><![CDATA[Gabriel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gómez-Chavarín]]></surname>
<given-names><![CDATA[Margarita]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Trigo-Tavera]]></surname>
<given-names><![CDATA[Francisco José]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional Autónoma de México Facultad de Medicina Veterinaria y Zootecnia Departamento de Medicina, Cirugía y Zootecnia para Équidos]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto Nacional de Pediatría Laboratorio de Bioquímica Genética ]]></institution>
<addr-line><![CDATA[ Ciudad de México]]></addr-line>
<country>México</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Instituto Nacional de Pediatría Laboratorio de Oncología Experimental ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Secretaría de la Defensa Nacionak Centro Ecuestre de Alto Rendimiento ]]></institution>
<addr-line><![CDATA[ Ciudad México]]></addr-line>
<country>México</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Universidad Nacional Autónoma de México Departamento de Fisiología Instituto de Investigaciones Biomédicas]]></institution>
<addr-line><![CDATA[ Ciudad de México]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af6">
<institution><![CDATA[,Universidad Nacional Autónoma de México Facultad de Medicina Departamento de Fisiología]]></institution>
<addr-line><![CDATA[ Ciudad de México]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af7">
<institution><![CDATA[,Universidad Nacional Autónoma de México Facultad de Medicina Veterinaria y Zootecnia Departamento de Patología]]></institution>
<addr-line><![CDATA[ Ciudad de México]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2023</year>
</pub-date>
<volume>14</volume>
<numero>1</numero>
<fpage>122</fpage>
<lpage>136</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2007-11242023000100122&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2007-11242023000100122&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2007-11242023000100122&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Insulin-like growth factor I (IGF-1) is the most important known growth factor for cartilage repair in horses. It promotes mitosis of chondrocytes, collagen II expression, and extra cellular matrix production. Osteoarthritis (OA) is the most common musculoskeletal condition that causes lameness and poor performance in sport horses. A total of 11 lame horses were clinically and radiographically evaluated, and all were confirmed to suffer a front metacarpophalangeal lameness by a positive flexion test, a low-4-point nerve block and an intraarticular block. Total protein, IGF-1, IL-6 and TNF( were determined by ELISA, demonstrating changes and different correlations between clinical condition, radiographic changes and degree of inflammation. All horses with joint associated pain and therefore associated lameness, demonstrated a significant increase of total protein (P&lt;0.0001) and IGF-1 concentration (P&lt;0.05). Concentrations of IL-6 and TNF( between controls and lame horses demonstrated significant differences (P&lt;0.01 and P&lt;0.001 respectively). Horses with less radiographic changes, demonstrated the highest IGF-1 expression in synovial fluid, and horses with more chronic OA conditions had very similar IGF-1 expression levels than control joints. In all lame joints, it was identified by Western blot a lighter isoform of IGF-1 (~7.5 kDa) which was inflammation related and it is the molecular weight of the mature peptide, and all control joints expressed a heavier isoform (~12 kDa). This finding could lead to new research for sequencing and targeting the isoform which is not expressed during an inflammatory process within a joint, and to have a better understanding of its role in the horse&#8217;s joint.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  El factor de crecimiento similar a la insulina I (IGF-1) es el factor de crecimiento conocido más importante para la reparación del cartílago en caballos. Promueve la mitosis de los condrocitos, la expresión de colágeno II y la producción de matriz extracelular. La osteoartritis (OA) es la condición musculoesquelética más común que causa cojera y bajo rendimiento en caballos deportivos. Se evaluó clínica y radiográficamente un total de 11 caballos cojos, y se confirmó que todos sufrían una cojera metacarpofalángica frontal mediante una prueba de flexión positiva, un bloqueo nervioso en 4 puntos bajos y un bloqueo intraarticular. La proteína total, IGF-1, IL-6 y TNF&#945; se determinaron por ELISA, lo que demostró cambios y diferentes correlaciones entre la condición clínica, los cambios radiográficos y el grado de inflamación. Todos los caballos con dolor asociado a las articulaciones y, por lo tanto, asociado a la cojera, mostraron un aumento significativo de la proteína total (P&lt;0.0001) y la concentración de IGF-1 (P&lt;0.05). Las concentraciones de IL-6 y TNF&#945; entre los controles y los caballos cojos mostraron diferencias significativas (P&lt;0.01 y P&lt;0.001 respectivamente). Los caballos con menos cambios radiográficos mostraron la mayor expresión de IGF-1 en el líquido sinovial, y los caballos con condiciones de OA más crónicas tuvieron niveles de expresión de IGF-1 muy similares a los de las articulaciones de control. En todas las articulaciones cojas, se identificó por medio de Western blot una isoforma de IGF-1 más ligera (~ 7.5 kDa) que estaba relacionada con la inflamación y es el peso molecular del péptido maduro, y todas las articulaciones de control expresaron una isoforma más pesada (~ 12 kDa). Este hallazgo podría conducir a una nueva investigación para secuenciar y apuntar a la isoforma que no se expresa durante un proceso inflamatorio dentro de una articulación, y para tener una mejor comprensión de su papel en la articulación del caballo.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Insulin growth factor 1 (IGF-1)]]></kwd>
<kwd lng="en"><![CDATA[Horse]]></kwd>
<kwd lng="en"><![CDATA[Osteoarthritis (OA)]]></kwd>
<kwd lng="en"><![CDATA[Lame]]></kwd>
<kwd lng="es"><![CDATA[Factor de crecimiento similar a la insulina 1 (IGF-1)]]></kwd>
<kwd lng="es"><![CDATA[Caballo]]></kwd>
<kwd lng="es"><![CDATA[Osteoartritis (OA)]]></kwd>
<kwd lng="es"><![CDATA[Cojera]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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