<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1870-7203</journal-id>
<journal-title><![CDATA[Acta médica Grupo Ángeles]]></journal-title>
<abbrev-journal-title><![CDATA[Acta méd. Grupo Ángeles]]></abbrev-journal-title>
<issn>1870-7203</issn>
<publisher>
<publisher-name><![CDATA[Grupo Ángeles, Servicios de Salud]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1870-72032025000400397</article-id>
<article-id pub-id-type="doi">10.35366/120523</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Interpretación y manejo de un perfil genómico complejo en cáncer de pulmón de células no pequeñas]]></article-title>
<article-title xml:lang="en"><![CDATA[Interpretation and management of a complex genomic profile in non-small cell lung cancer]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González Espinoza]]></surname>
<given-names><![CDATA[Iván Romarico]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Castro Ponce]]></surname>
<given-names><![CDATA[Abraham]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sánchez Sosa]]></surname>
<given-names><![CDATA[Sergio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Camarín Sánchez]]></surname>
<given-names><![CDATA[Efraín Isaías]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hernández Zenteno]]></surname>
<given-names><![CDATA[María Fernanda]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Juárez Salazar]]></surname>
<given-names><![CDATA[Gabriela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Chiquillo Domínguez]]></surname>
<given-names><![CDATA[Mariana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Yarce Cabrera]]></surname>
<given-names><![CDATA[Luis Miguel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Angeles Puebla  ]]></institution>
<addr-line><![CDATA[Puebla ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Angeles Puebla  ]]></institution>
<addr-line><![CDATA[Puebla ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital Angeles Puebla  ]]></institution>
<addr-line><![CDATA[Puebla ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Hospital Angeles Puebla  ]]></institution>
<addr-line><![CDATA[Puebla ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Hospital Angeles Puebla  ]]></institution>
<addr-line><![CDATA[Puebla ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2025</year>
</pub-date>
<volume>23</volume>
<numero>4</numero>
<fpage>397</fpage>
<lpage>400</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1870-72032025000400397&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1870-72032025000400397&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1870-72032025000400397&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen:  Introducción:  La caracterización genómica es vital para el tratamiento y pronóstico del cáncer de pulmón de células no pequeñas (CPCNP), pero su interpretación puede ser un reto.  Presentación del caso:  Hombre de 62 años con adenocarcinoma de CPCNP, presentó mutación en EGFR L861Q, EGFRamp y METamp. Tras el tratamiento inicial con osimertinib, hubo una respuesta mixta, con disminución general, pero con nuevas lesiones hepáticas con PIK3CA y BRAF mutados. Tras la metástasis a sistema nervioso central, el nuevo perfil encontró mutaciones en EGFR y MET nuevamente.  Conclusiones:  La caracterización genómica es crucial para guiar el tratamiento. Las nuevas terapias promueven la heterogeneidad tumoral. Un enfoque multidisciplinario es necesario.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract:  Introduction:  Genomic characterization is vital for the treatment and prognosis of non-small cell lung cancer (NSCLC) but can be challenging to interpret.  Case presentation:  A 62-year-old man with NSCLC adenocarcinoma had EGFR L861Q mutation, EGFR amplification, and MET amplification. Initial treatment with osimertinib resulted in mixed responses, with overall reduction but new hepatic lesions with PIK3CA and BRAF mutations. After CNS metastasis, the new profile again found mutations in EGFR and MET.  Conclusions:  Genomic characterization is crucial for guiding treatment. New therapies promote tumor heterogeneity, so a multidisciplinary approach is necessary.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[cáncer de pulmón de células no pequeñas]]></kwd>
<kwd lng="es"><![CDATA[osimertinib]]></kwd>
<kwd lng="es"><![CDATA[EGFR L861Q]]></kwd>
<kwd lng="es"><![CDATA[perfil genómico]]></kwd>
<kwd lng="en"><![CDATA[non-small cell lung cancer]]></kwd>
<kwd lng="en"><![CDATA[osimertinib]]></kwd>
<kwd lng="en"><![CDATA[EGFR L861Q]]></kwd>
<kwd lng="en"><![CDATA[genomic profiling]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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</article>
