<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1870-7203</journal-id>
<journal-title><![CDATA[Acta médica Grupo Ángeles]]></journal-title>
<abbrev-journal-title><![CDATA[Acta méd. Grupo Ángeles]]></abbrev-journal-title>
<issn>1870-7203</issn>
<publisher>
<publisher-name><![CDATA[Grupo Ángeles, Servicios de Salud]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1870-72032024000400338</article-id>
<article-id pub-id-type="doi">10.35366/117531</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Variantes genéticas y miocardiopatía, dos espectros clínicos de una misma enfermedad]]></article-title>
<article-title xml:lang="en"><![CDATA[Genetic variants and cardiomyopathy, two clinical spectra of the same disease]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Chávez-Ocaña]]></surname>
<given-names><![CDATA[Sonia del Carmen]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Alonso-Bello]]></surname>
<given-names><![CDATA[César Daniel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Estrada-Martínez]]></surname>
<given-names><![CDATA[Aholibama]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Moncayo-Coello]]></surname>
<given-names><![CDATA[Carol Vivian]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martínez-Castillo]]></surname>
<given-names><![CDATA[Joanna]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Medel-Jiménez]]></surname>
<given-names><![CDATA[Octavio Alberto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rojo-Gutiérrez]]></surname>
<given-names><![CDATA[María Isabel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Secretaría de Salud Hospital Juárez de México Servicio de Genética]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Secretaría de Salud Hospital Juárez de México Servicio de Alergia e Inmunología Clínica]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Secretaría de Salud Hospital Juárez de México Servicio de Cardiología]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Instituto Mexicano del Seguro Social Hospital de Especialidades Centro Médico La Raza Servicio de Cardiología, UMAE]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Secretaría de Salud Hospital Juárez de México Dirección Médica]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>10</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>10</month>
<year>2024</year>
</pub-date>
<volume>22</volume>
<numero>4</numero>
<fpage>338</fpage>
<lpage>341</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1870-72032024000400338&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1870-72032024000400338&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1870-72032024000400338&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: La miocardiopatía hipertrófica es una enfermedad hereditaria del músculo cardiaco que afecta a aproximadamente una de cada 500 personas. Los síntomas del paciente pueden ser mínimos o implacablemente progresivos con insuficiencia cardiaca resultante y/o muerte cardiaca súbita. Las alteraciones en el gen MYH7 se han reportado como miocardiopatía hipertrófica y miocardiopatía dilatada. Presentamos dos casos clínicos con mutaciones identificadas en el gen MYH7, uno con la manifestación típica con hipertrofia relacionada con hipertensión arterial sistémica y otro con presentación como cardiomiopatía dilatada.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: Hypertrophic cardiomyopathy is an inherited heart muscle disease that affects about 1 in 500 people. The patient&#8217;s symptoms may be minimal or relentlessly progressive, with resultant heart failure and/or sudden cardiac death. Alterations in the MYH7 gene have been reported as hypertrophic cardiomyopathy and dilated cardiomyopathy. We present two clinical cases with mutations identified in the MYH7 gene, one with the typical manifestation of hypertrophy related to systemic arterial hypertension and another with presentation as dilated cardiomyopathy.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[MYH7]]></kwd>
<kwd lng="es"><![CDATA[cardiomiopatía dilatada]]></kwd>
<kwd lng="es"><![CDATA[genética]]></kwd>
<kwd lng="es"><![CDATA[cardiomiopatía]]></kwd>
<kwd lng="es"><![CDATA[hipertrofia]]></kwd>
<kwd lng="en"><![CDATA[MYH7]]></kwd>
<kwd lng="en"><![CDATA[dilated cardiomyopathy]]></kwd>
<kwd lng="en"><![CDATA[genetics]]></kwd>
<kwd lng="en"><![CDATA[cardiomyopathy]]></kwd>
<kwd lng="en"><![CDATA[hypertrophy]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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</article>
